P30- Core Grant for Vision Research

描述（由申请人提供）：继续支持要求在埃默里大学眼科系NEI核心中心补助金。该核心中心资助更新申请包括三个模块：（1）结构生物学和成像，（2）功能基因组学和蛋白质组学，以及（3）生物信息学和生物统计学。 过去的核心中心赠款已成功地利用支持协作视觉研究和服务，涉及32名教师（包括超过21名NEI资助的主要研究人员），16名博士后研究员，6名博士前研究员，并在过去五年中产生了250多篇出版物。 结构生物学和成像模块增加了免疫组织化学，体内和体外共聚焦显微镜，荧光图像分析，体内荧光和磁共振图像的光和电子显微镜服务。功能基因组学和蛋白质组学模块提供合成寡核苷酸、蛋白质序列、PCR、基因表达激光微捕获和流式细胞术等服务。生物信息学和生物统计学模块将提供先进的计算分析和生物信息学资源方面的综合生物统计学、生物信息学和数据管理。 核心模块已经并将继续通过提供共同的集中服务来提高我们的研究生产力，以刺激和促进教师之间的合作研究，并吸引其他大学学科进行视觉研究。这个核心设施也作为一个集中的视力研究机构在亚特兰大，教师从埃默里大学，耶基斯地区灵长类动物中心，格鲁吉亚理工学院，格鲁吉亚州立大学，莫尔豪斯医学院，退伍军人管理局医疗中心和疾病控制和预防中心可以进行视力研究的合作研究。核心设施还在我们的前和博士后研究员的研究项目中发挥作用，该项目由我们的部门NEI培训补助金（T32 EY 007092 -19）支持，最近更新了未来五年（2004-2009）。

DESCRIPTION (provided by applicant): Continued support is requested for the NEI Core Center Grant in the Department of Ophthalmology at Emory University. This Core Center Grant renewal application includes three Modules: (1) Structural Biology and Imaging, (2) Functional Genomics and Proteomics, and (3) Bioinformatics and Biostatistics. The past Core Center grant has successfully utilized supporting collaborative vision research and service involving 32 faculty (including more than 21 NEI funded principal investigators), 16 postdoctoral fellows, six predoctoral fellows and generating over 250 publications over the past five years. The Structural Biology and Imaging Module adds immunohistochemistry, in vivo and in vitro confocal microscopy, fluoresence image analysis, in vivio flurophotomery and magnetic resonance image to the light and electron microscopy services. The Functional Genomics and Proteomics module provides services for synthetic oligonucleotides, protein sequences, PCR, laser microcapture with gene expression and flow cytometry. The Bioinformatics and Biostatistics Module will provide integrated biostatistics, bioinformatics and data management in advanced computational analysis and bioinformatics resources. The Core Modules have and will continue to enhance our research productivity by providing common centralized services to stimulate and facilitate collaborative studies between faculty an to attract other university disciplines to vision research. This Core facility also serves as a centralized vision research facility in Atlanta where faculty from Emory University, Yerkes Regional Primate Center, Georgia Institute of Technology, Georgia State University, Morehouse School of Medicine, The Veterans Administration Medical Center and the Centers for Disease Control and Prevention can undertake collaborative studies in vision research. The Core facilities also serve a role in the research projects of our pre- and postdoctoral fellows supported by our departmental NEI Training Grant (T32 EY007092-19), recently renewed for the next five years (2004-2009).