UMB Non-Human Primate Core

UMB 非人类灵长类核心

• 批准号: 7672164
• 负责人: LOUIS James DE TOLLA
• 金额: $ 10.52万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-03 至 2014-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7672164
• 关键词: Animal Housing; Animal Model; Animals; Anthrax disease; Area; Arts; Baltimore; Biohazardous Substance; Biomedical Research; Bioterrorism; Categories; Centers for Disease Control and Prevention (U.S.); Clinical; Consultations; Core Facility; Disease; Emerging Communicable Diseases; Guidelines; Human Resources; Infectious Agent; Infectious Diseases Research; Maryland; Medical; Methodology; Pathogenesis; Research; Research Personnel; Research Support; Safety; Services; Shigella dysenteriae; Smallpox; Testing; Therapeutic; Universities; Vaccines; Veterinary Medicine; biodefense; drug efficacy; experience; innovation; meetings; nonhuman primate; pathogen; vaccine development; vaccine efficacy

Optimal utilization of nonhuman primates for biodefense and emerging pathogens research requires a facility where animals are housed in appropriate biocontainment and research personnel experienced in the methodologies required for infectious disease research and vaccine development. The non-human primate (NHP) Core at the University of Maryland, Baltimore will provide state-of-the-art animal biosafety levels (ABSL) 2 and 3 facilities for biodefense research using nonhuman primates. Currently, our facilities support projects aimed at developing vaccines against anthrax, smallpox and S. dysenteriae 1 vaccines. These projects use NHPs as animal models for studying disease pathogenesis and testing vaccine efficacy and safety. Our facilities fully support biohazard research at ABSL-2 and 3 levels and meet all NIH/CDC guidelines. Our expert personnel will provide consultation services to investigators planning to use the NHP core for biohazard studies. We will make available our extensive experience in the utilization of NHPs for pathogenesis research and vaccine development for various CDC category A, B and C agents. Hence, the NHP core will be a very important component to support proposals aimed at developing innovative therapeutics against bioterrorism agents.

最佳利用非人灵长类动物进行生物防御和新出现的病原体研究需要一个设施 如果动物被圈养在适当的生物隔离中， 传染病研究和疫苗开发所需的方法。非人灵长类 (NHP)位于巴尔的摩的马里兰州大学的核心将提供最先进的动物生物安全水平 （ABSL）2和3个使用非人类灵长类动物进行生物防御研究的设施。目前，我们的设施支持 这些项目旨在开发针对炭疽、天花和沙门氏菌的疫苗。大肠杆菌1型疫苗。这些 项目使用NHP作为动物模型来研究疾病发病机制和测试疫苗功效， 安全为代价的我们的设施完全支持ABSL-2和3级的生物危害研究，并符合所有NIH/CDC 指南我们的专家人员将为计划使用NHP的研究人员提供咨询服务 生物危害研究的核心。我们将提供我们在利用NHP方面的丰富经验， 针对各种CDC类别A、B和C剂的致病机理研究和疫苗开发。所以 NHP核心将是一个非常重要的组成部分，以支持旨在发展创新的建议， 生物恐怖制剂的治疗方法。