Neurobiological causes of overeating in a rodent model - hedonic versus homeostatic control

啮齿动物模型暴饮暴食的神经生物学原因——享乐与稳态控制

• 批准号: nhmrc : 568728
• 负责人: Prof Margaret Morris
• 金额: $ 28.75万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/neurobiological-causes-overeating-homeostatic-control/96837
• 关键词: Neurobiological; causes; overeating; rodent; model

Unlimited access to palatable high fat foods, in conjunction with a sedentary life style, has led to increased obesity. Exactly what mechanisms drive over consumption of energy rich foods and override mechanisms that normally regulate body weight? This project will examine feeding behaviour in rats fed palatable high fat diet, to examine when and how they eat. The contribution of brain chemicals implicated in addiction to this eating, and the impact of withdrawal of food will be examined.

无限制地获得可口的高脂肪食物，加上久坐不动的生活方式，导致肥胖增加。究竟是什么机制导致了高能量食物的过度消费，并推翻了通常调节体重的机制？这个项目将研究大鼠的摄食行为，喂食可口的高脂肪饮食，以研究它们何时以及如何进食。大脑化学物质的贡献与这种饮食成瘾有关，以及戒断食物的影响将被检查。