Neurobiological causes of overeating in a rodent model - hedonic versus homeostatic control

无限制地享用美味的高脂肪食物，再加上久坐不动的生活方式，导致了肥胖的增加。究竟是什么机制驱使人们过度摄入高能量食物，并凌驾于正常的体重调节机制之上？该项目将研究喂食高脂肪食物的大鼠的进食行为，以研究它们何时以及如何进食。大脑中与这种饮食成瘾有关的化学物质的作用，以及停止进食的影响将被研究。

Unlimited access to palatable high fat foods, in conjunction with a sedentary life style, has led to increased obesity. Exactly what mechanisms drive over consumption of energy rich foods and override mechanisms that normally regulate body weight? This project will examine feeding behaviour in rats fed palatable high fat diet, to examine when and how they eat. The contribution of brain chemicals implicated in addiction to this eating, and the impact of withdrawal of food will be examined.