Gender Disparities and Vascular Function in Chronic Kidney Disease Outcomes
慢性肾脏病结果中的性别差异和血管功能
基本信息
- 批准号:8605536
- 负责人:
- 金额:$ 15.96万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-05-01 至 2018-02-28
- 项目状态:已结题
- 来源:
- 关键词:AbstinenceAchievementAddressAdherenceAdultAffectAgeAngiotensin-Converting Enzyme InhibitorsAreaAtherosclerosisAwardBehavior TherapyBiologicalBlood PressureBlood VesselsCardiovascular DiseasesCardiovascular systemChicagoChronic Kidney FailureChronic Kidney InsufficiencyClinicalClinical SciencesCohort StudiesDataData AnalysesData CollectionDevelopmentDevelopment PlansDiabetes MellitusDisease OutcomeDisease ProgressionDoctor of PhilosophyEducational InterventionEnd stage renal failureEpidemiologyEstrogensEthnic OriginEventExerciseFoundationsFundingGenderGeneral PopulationGlucoseGoalsGuidelinesHealth Services AccessibilityHealth behaviorHigh PrevalenceIllinoisImpairmentIncidenceIndividualInformation SystemsInterventionK-Series Research Career ProgramsKidneyKidney DiseasesKnowledgeLeadLife StyleLipidsMeasuresMediatingMentored Patient-Oriented Research Career Development AwardMentorsMentorshipMethodologyMinorityMinority GroupsNational Health and Nutrition Examination SurveyNational Institute of Diabetes and Digestive and Kidney DiseasesObservational StudyOutcomeParticipantPatientsPerformancePhysical FunctionPhysiciansPhysiologic pulsePilot ProjectsPopulationPrevalencePublic HealthPublic Health SchoolsRaceResearchResearch InfrastructureResearch PersonnelResistanceResourcesRisk FactorsRoleSamplingScientistSex CharacteristicsSmokingTestingTimeTrainingTranslational ResearchUnited StatesUnited States National Institutes of HealthUniversitiesWomanWomen&aposs Healthblood pressure regulationcardiovascular risk factorcareercareer developmentdesigndiet and exerciseendothelial dysfunctionexperiencehealth disparityhealth inequalitiesimprovedlifestyle interventionmenmortalitymultidisciplinaryprotective effectpublic health relevanceskills
项目摘要
DESCRIPTION (provided by applicant): The candidate for this Mentored Patient-Oriented Research Career Development Award (K23) is Ana C. Ricardo, MD, MPH, a nephrologist at the University of Illinois at Chicago (UIC). Dr. Ricardo's short-term goals are to gain experience and develop skills by conducting research focused on gender disparities in chronic kidney disease (CKD), and the contribution of gender differences in endothelial function to these disparities. Her
long-term career goals are to become an independent investigator conducting research focused on reducing health inequalities in CKD through lifestyle interventions. To achieve her goals, Dr. Ricardo has assembled a comprehensive career development plan that consists of mentored research and didactic coursework at the UIC School of Public Health. Dr. Ricardo's strong team of mentors and collaborators includes world-class experts with longstanding NIH funding and extensive mentorship experience. Her primary mentor, James P. Lash, MD, is an expert in the epidemiology of CKD in minority populations; Martha L. Daviglus, MD, PhD, her co-mentor, has expertise in the epidemiology of cardiovascular disease. The proposal also includes a multidisciplinary team of collaborators with expertise in the areas of women's health, longitudinal
data analyses, and the influence of exercise on vascular function. Dr. Ricardo's successful development into an independent physician-scientist will be facilitated by the extensive facilities
and resources available at UIC which include the Clinical and Translational Science Award, the Center for Research on Women and Gender, and the School of Public Health. Dr. Ricardo's research will advance her skills in both primary data collection and longitudinal data analyses. The proposal leverages the infrastructure of the NIH- funded Chronic Renal Insufficiency Cohort (CRIC) Study, a large and diverse observational study of adults with CKD. Evidence suggests that there are significant gender-related disparities in CKD. Whereas data from the United States Renal Data System indicate that men have 1.5 times greater incidence of end-stage renal disease, a higher prevalence of CKD in women was seen in the National Health and Nutrition Examination Survey. Several studies suggest that men have more rapid CKD progression, but this has not been a consistent finding. Furthermore, previous studies were not designed to address this question and included few racial/ethnic minorities. In the general population, there is evidence that differential rates of cardiovascular outcomes in women and men may be related to gender differences in endothelial function, which have been in part attributed to the protective effect of estrogen in women. Moreover, limited data suggest that endothelial dysfunction may be a predictor of CKD progression. However, the contribution of endothelial function to gender disparities in CKD progression is not known. This is an area of significance because studies of non-CKD populations suggest that endothelial function may be improved with pharmacologic therapy (e.g., ACE- inhibitors) or lifestyle interventions (e.g., exercise). The specific aims for the proposed project are to 1) Examine gender disparities in kidney and cardiovascular outcomes in the CRIC Study; 2) Examine gender differences in endothelial function and the role of endothelial function as a predictor of CKD progression in 150 University of Illinois CRIC Study participants; and 3) Evaluate the feasibility of a 12-week pilot resistance exercise training intervention and its effect on endothelial function and cardiovascular
risk factors in men and women with CKD. This Career Development Award will provide the foundation for Dr. Ricardo to pursue an independent research career dedicated to reducing health disparities in CKD.
描述(由申请人提供):本次以患者为导向的研究职业发展奖 (K23) 的候选人是 Ana C. Ricardo,医学博士、公共卫生硕士,她是伊利诺伊大学芝加哥分校 (UIC) 的肾脏病专家。 Ricardo 博士的短期目标是通过开展专注于慢性肾病 (CKD) 性别差异以及内皮功能性别差异对这些差异的影响的研究来获得经验和发展技能。她
长期职业目标是成为一名独立研究者,开展专注于通过生活方式干预减少 CKD 健康不平等的研究。为了实现她的目标,里卡多博士制定了一个全面的职业发展计划,其中包括在伊利诺伊大学芝加哥分校公共卫生学院的指导研究和教学课程。 Ricardo 博士强大的导师和合作者团队包括拥有长期 NIH 资助和丰富指导经验的世界级专家。她的主要导师 James P. Lash 医学博士是少数族裔 CKD 流行病学专家。她的共同导师 Martha L. Daviglus 医学博士、哲学博士拥有心血管疾病流行病学方面的专业知识。该提案还包括一个由在妇女健康、纵向领域具有专业知识的合作者组成的多学科团队。
数据分析以及运动对血管功能的影响。广泛的设施将促进里卡多博士成功发展成为一名独立的医师科学家
UIC 提供的资源包括临床和转化科学奖、妇女和性别研究中心以及公共卫生学院。里卡多博士的研究将提高她在初级数据收集和纵向数据分析方面的技能。该提案利用了 NIH 资助的慢性肾功能不全队列 (CRIC) 研究的基础设施,这是一项针对成人 CKD 的大型且多样化的观察性研究。有证据表明 CKD 存在显着的性别差异。美国肾脏数据系统的数据表明,男性终末期肾病的发病率是男性的 1.5 倍,而国家健康和营养检查调查显示,女性 CKD 的患病率更高。多项研究表明男性 CKD 进展更快,但这并不是一个一致的发现。此外,以前的研究并不是为了解决这个问题,并且只包括少数种族/族裔。在普通人群中,有证据表明,女性和男性心血管结局发生率的差异可能与内皮功能的性别差异有关,这在一定程度上归因于雌激素对女性的保护作用。此外,有限的数据表明内皮功能障碍可能是 CKD 进展的预测因子。然而,内皮功能对 CKD 进展中性别差异的影响尚不清楚。这是一个具有重要意义的领域,因为对非 CKD 人群的研究表明,药物治疗(例如,ACE 抑制剂)或生活方式干预(例如,运动)可能会改善内皮功能。拟议项目的具体目标是 1) 检查 CRIC 研究中肾脏和心血管结果的性别差异; 2) 检查 150 名伊利诺伊大学 CRIC 研究参与者内皮功能的性别差异以及内皮功能作为 CKD 进展预测因子的作用; 3) 评估为期 12 周的试点阻力运动训练干预的可行性及其对内皮功能和心血管的影响
男性和女性 CKD 的危险因素。该职业发展奖将为 Ricardo 博士从事致力于减少 CKD 健康差距的独立研究职业奠定基础。
项目成果
期刊论文数量(0)
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Ana Catherine Ricardo其他文献
Ana Catherine Ricardo的其他文献
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{{ truncateString('Ana Catherine Ricardo', 18)}}的其他基金
Sleep-Disordered Breathing and Outcomes in Chronic Kidney Disease
睡眠呼吸障碍和慢性肾病的结果
- 批准号:
10198915 - 财政年份:2019
- 资助金额:
$ 15.96万 - 项目类别:
Sleep-Disordered Breathing and Outcomes in Chronic Kidney Disease
睡眠呼吸障碍和慢性肾病的结果
- 批准号:
10405520 - 财政年份:2019
- 资助金额:
$ 15.96万 - 项目类别:
Sleep-Disordered Breathing and Outcomes in Chronic Kidney Disease
睡眠呼吸障碍和慢性肾病的结果
- 批准号:
10634531 - 财政年份:2019
- 资助金额:
$ 15.96万 - 项目类别:
Gender Disparities and Vascular Function in Chronic Kidney Disease Outcomes
慢性肾脏病结果中的性别差异和血管功能
- 批准号:
8814214 - 财政年份:2013
- 资助金额:
$ 15.96万 - 项目类别:
Gender Disparities and Vascular Function in Chronic Kidney Disease Outcomes
慢性肾脏病结果中的性别差异和血管功能
- 批准号:
9232902 - 财政年份:2013
- 资助金额:
$ 15.96万 - 项目类别:
Gender Disparities and Vascular Function in Chronic Kidney Disease Outcomes
慢性肾脏病结果中的性别差异和血管功能
- 批准号:
8441885 - 财政年份:2013
- 资助金额:
$ 15.96万 - 项目类别:
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