Training in Molecular Physics of Biological Systems

生物系统分子物理学培训

• 批准号: 8695403
• 负责人: MICHELLE D. WANG
• 金额: $ 49.65万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-09-30 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8695403
• 关键词: Molecular; Physics; Training; biological systems

DESCRIPTION (provided by applicant): This renewal proposal describes plans to continue Cornell's Molecular Biophysics Training Grant Program, which offers vigorous interdisciplinary training that combines physical and biological sciences. The program, now in its 23rd year, further advances the training of our most motivated and well-qualified students by focusing their graduate academic work around a core curriculum in areas spanning both physical and biological disciplines. The trainees selected to participate may have undergraduate degrees in either physical or biological sciences and must have been admitted to the Graduate School at Cornell for training leading to the Ph.D. in one of the Graduate Fields of the twenty-eight participating faculty spanning eight departments, seventeen fields, and three Colleges. All participating faculty are associated with Cornell's well established and continuously growing Biophysics Program, and have well- funded quality research programs either in physics with strong biological applications or in biology with strong physical connections. The overall research interests of the faculty are broadly distributed and include: the investigation of structue and function of proteins and other macromolecules using theoretical approaches; structure determination by synchrotron X- ray crystallography; electron spin resonance spectroscopy and multidimensional NMR; single molecule studies of dynamics of molecular motors; structures and molecular mechanisms of cell membranes, receptors, and neurotransmitters and associated cellular functions; materials and technology developments including nonlinear laser microscopy, steady-state and time resolved spectroscopy and imaging, single channel recording, optical tweezers, and nanofabrication. Through collaborations and University center facilities, Cornell offers a natural fertile ground for innovation and creative research ideas. The program supports 12 trainees each year, with a total duration of support for each individual at 2-3 years. Trainees undertake interdisciplinary studies with advanced courses in mathematics, quantum mechanics, statistical thermodynamics, biochemistry, molecular and cell biology, computation and instrumentation, and other special topics. In addition, students participate in multiple program functions including a weekly Biophysics Colloquium, a student and faculty retreat, and Summer Student Seminars. These activities serve to provide continuity and program identity within the far- reaching interdisciplinary structure of the program. Thesis research and collaborations in the laboratories of the participating faculty complete preparation for a career of teaching and research in molecular biophysics. Through these experiences, they gain exposure to, and experience in, interdisciplinary biomedical research.

描述(由申请人提供)：这份续订建议书描述了继续康奈尔大学分子生物物理学培训资助计划的计划，该计划提供结合物理和生物科学的强有力的跨学科培训。该项目现已进入第23个年头，通过将研究生的学术工作重点放在跨越物理和生物学科的核心课程上，进一步推进了对最有积极性和最合格学生的培训。被选中参加培训的学生可能拥有物理或生物科学的本科学位，并且必须被康奈尔大学研究生院录取，以便在28个参与教师的研究生场之一获得博士学位，该研究生院横跨8个系、17个领域和3个学院。所有参与的教员都与康奈尔大学建立良好且不断发展的生物物理学计划有关，并拥有资金充足的高质量研究计划，无论是在具有强大生物学应用的物理学领域，还是在具有强大物理联系的生物学领域。其总体研究兴趣广泛，包括：用理论方法研究蛋白质和其他大分子的结构和功能；用同步辐射X射线结晶学确定结构；电子自旋共振光谱和多维核磁共振；分子马达动力学的单分子研究；细胞膜、受体和神经递质的结构和分子机制以及相关的细胞功能；材料和技术发展，包括非线性激光显微镜、稳态和时间分辨光谱和成像、单通道记录、光钳和纳米制造。通过合作和大学中心设施，康奈尔大学为创新和创造性的研究想法提供了天然的肥沃土壤。该计划每年支持12名学员，每个人的总支持期限为2-3年。受训人员通过数学、量子力学、统计热力学、生物化学、分子和细胞生物学、计算和仪器等高级课程进行跨学科研究，以及其他专题。此外，学生还参加多项计划活动，包括每周一次的生物物理座谈会、学生和教职员工的静修活动以及暑期学生研讨会。这些活动的作用是在影响深远的计划跨学科结构中提供连续性和计划特性。论文研究与合作 参与的教员的实验室为分子生物物理学的教学和研究生涯做好了充分的准备。通过这些经验，他们接触到了跨学科的生物医学研究，并获得了经验。