Analyzing age-related changes of brain activation in subjects native space

描述（由申请人提供）：这是一个指导研究科学家发展奖（K 01）的申请。该项目的目标是为申请人提供所需的先进技能，以建立一个独立的研究计划，在认知老化使用神经影像学方法来了解神经基础的年龄相关的认知变化。申请人提出了一个全面的培训计划，该计划将教学指导与既定的研究人员相结合;正式的课程;参加哥伦比亚大学正在进行的研讨会，与导师一对一的指导阅读，最后从头到尾进行前瞻性试点研究。本研究的目的是探讨在延迟项目再认任务中，年轻和老年健康被试的事件相关fMRI激活的差异。本计画提出两种新方法以解决：a）功能磁振造影资料分析的局限性差及B）缺乏有效的主观任务难度测量。本项目将利用认知神经科学部正在进行的三项研究数据来开发和评估所提出的方法。此外，一个新的试点研究将收集与修订后的延迟字母识别任务，这是专门为本项目的目标。因此，拟议的项目目标将阐明与衰老相关的神经生物学变化的多种措施之间的相互关系，并将作为申请人建立一个独立的研究人员职业生涯在老龄化人群中进行神经影像学研究的桥梁。

DESCRIPTION (provided by applicant): This is an application for a Mentored Research Scientist Development Award (K01). The goal of the proposed project is to provide the applicant with the advanced skills needed to establish an independent research program in cognitive aging using neuroimaging approach to understanding neural basis underlying age-related cognitive changes. The Applicant proposes a comprehensive training plan which combines didactic instruction with established researchers; formal coursework; participation in ongoing seminars in Columbia University, one-to-one directed readings with mentors, and finally conduction of a prospective pilot study from beginning to end. The goal of this study will be to explore the difference in the event-related fMRI activation of young and old healthy participants groups during a delayed item recognition task. Two new approaches are proposed in this project to address; a) poor localization of fMRI data analysis and b) lack of effective measure of subjective task difficulty. This project will take advantage of three of the on-going studies data n the Cognitive Neuroscience Division for the development and evaluation of the proposed methodologies. In addition, a new pilot study will be collected with a revised delayed letter recognition task which is specifically designed for the goal of this project. The proposed project aims will therefore elucidate the interrelationships between multiple measures of neurobiological changes associated with aging and will serve as a bridge for the applicant to establish an independent investigator career in conducting neuroimaging studies in aging populations.