Shape Memory Polymer Devices for Treating Stroke

我们建议开发用于治疗中风患者的形状记忆聚合物(SMP)介入设备 目前有有限的治疗选择(在美国为每年450,000)。两台车的研制与测试 提出了补充装置：用于填充动脉瘤的泡沫和机械血栓提取系统。 这种泡沫将解决出血性中风的一个主要原因。血栓提取系统将解决 目前临床需要治疗急性缺血性中风，是第二代设备，基于 我们最初资助期的结果。 这项提议的基础是多学科团队和现有的合作伙伴关系 LLNL和加州大学戴维斯医学中心(UCD)的医疗技术计划。该团队由以下成员组成 四位合作伙伴：邓肯·梅特兰(LLNL)、托马斯·威尔逊(LLNL)、朱迪·范德沃特(UCD)和乔纳森 哈特曼(Hartman)。在我们最初的BRP奖项的头四年里，我们展示了重要的成果 这强化了我们最初的假设，即这些相对较新的材料将使小说和 临床上可行的治疗/预防中风的机械装置。第一个奖项期间的主要发展 期间是当前提议的使能基石：具有改进的新型SMP聚氨酯 热机械、光学和生物相容性；SMP泡沫；成功的动物模型和 生物兼容性研究；多阶段3D制造技术；以及大量的分析性、实验性的 以及应用于材料属性和设备-主体相互作用的计算工具。 在第二个五年支持期限结束时，我们将能够寻求商业支持 将设备/技术转化为工业，并通过这一过程进入临床。

We propose to develop shape memory polymer (SMP) interventional devices for treating stroke victims that currently have limited therapeutic alternatives (450,000/yr in the USA). The development and testing of two complementary devices is proposed: a foam for filling aneurysms and a mechanical clot extraction system. The foam will address a major cause of hemorrhagic strokes. The clot extraction system will address the current clinical need for an acute ischemic stroke treatment and is a second generation device based on the results from our initial funding period. The foundation of this proposal is the multidisciplinary team and the existing partnership that exists between the Medical Technology Program at LLNL and UC Davis Medical Center (UCD). The team is comprised of the four co-Pis: Duncan Maitland (LLNL), Thomas Wilson (LLNL), Judy Van de Water (UCD) and Jonathan Hartman (UCD). During our first four years of the initial BRP award we have demonstrated significant results that strengthen our original hypothesis that these relatively new materials will make possible novel and clinically feasible mechanical devices for treating/preventing stroke. Key developments during the first award period are the enabling cornerstones of the current proposal: novel SMP polyurethanes with improved thermomechanical, optical and biocompatibility properties; SMP foams; successful animal model and biocompatibility studies; multi-stage 3D fabrication techniques; and a large body of analytical, experimental and computational tools brought to bear on material properties and device-body interactions. At the end of a second five-year term of support we will be in a position to pursue commercial support for transferring the devices/technology to industry and, through this process, into the clinic.