Shape Memory Polymer Devices for Treating Stroke

我们建议开发用于治疗中风患者的形状记忆聚合物（SMP）介入装置， 目前有有限的治疗选择（450，000/年在美国）。开发和测试两个 提出了一种互补装置：用于填充动脉瘤的泡沫和机械凝块提取系统。 泡沫将解决出血性中风的主要原因。凝块提取系统将解决 目前临床需要急性缺血性中风治疗，是第二代设备的基础上， 从我们最初的融资周期来看。 这一建议的基础是多学科小组和现有的伙伴关系， LLNL和加州大学戴维斯分校医学中心（UCD）的医疗技术计划。该小组由 四个co-Pis：邓肯梅特兰（LLNL），托马斯威尔逊（LLNL），朱迪货车德水（UCD）和乔纳森 哈特曼（UCD）。在我们最初的BRP奖项的前四年中，我们已经展示了显着的成果 这加强了我们最初的假设，即这些相对较新的材料将使新颖和 用于治疗/预防中风的临床上可行的机械装置。第一次授标期间的主要发展 期间是本提案的基础：具有改进的 热机械、光学和生物相容性; SMP泡沫;成功的动物模型和 生物相容性研究;多阶段3D制造技术;以及大量的分析，实验 和计算工具带来的影响，对材料性能和设备的身体相互作用。 在第二个五年支持期结束时，我们将能够寻求商业支持， 将设备/技术转移到行业，并通过此过程进入临床。

We propose to develop shape memory polymer (SMP) interventional devices for treating stroke victims that currently have limited therapeutic alternatives (450,000/yr in the USA). The development and testing of two complementary devices is proposed: a foam for filling aneurysms and a mechanical clot extraction system. The foam will address a major cause of hemorrhagic strokes. The clot extraction system will address the current clinical need for an acute ischemic stroke treatment and is a second generation device based on the results from our initial funding period. The foundation of this proposal is the multidisciplinary team and the existing partnership that exists between the Medical Technology Program at LLNL and UC Davis Medical Center (UCD). The team is comprised of the four co-Pis: Duncan Maitland (LLNL), Thomas Wilson (LLNL), Judy Van de Water (UCD) and Jonathan Hartman (UCD). During our first four years of the initial BRP award we have demonstrated significant results that strengthen our original hypothesis that these relatively new materials will make possible novel and clinically feasible mechanical devices for treating/preventing stroke. Key developments during the first award period are the enabling cornerstones of the current proposal: novel SMP polyurethanes with improved thermomechanical, optical and biocompatibility properties; SMP foams; successful animal model and biocompatibility studies; multi-stage 3D fabrication techniques; and a large body of analytical, experimental and computational tools brought to bear on material properties and device-body interactions. At the end of a second five-year term of support we will be in a position to pursue commercial support for transferring the devices/technology to industry and, through this process, into the clinic.