Bioinformatics and Data Management Core

生物信息学和数据管理核心

基本信息

  • 批准号:
    9205191
  • 负责人:
  • 金额:
    $ 27.81万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2017
  • 资助国家:
    美国
  • 起止时间:
    2017-09-15 至 2022-08-31
  • 项目状态:
    已结题

项目摘要

SUMMARY The primary objectives of the Bioinformatics and Data Management Core (BDMC) are to: (1) develop and implement standardized data acquisition and data analysis protocols across the NexGen AD Models Center (NG-ADMC), (2) acquire and integrate external data to inform AD animal models generated by the NG-ADMC, and (3) create and maintain a publicly available database to house research data generated by the NG-ADMC. The BDMC is led by faculty members with a long-standing history of directing bioinformatics, statistics, and data cores, with particular expertise in AD and neurology. The BDMC will be instrumental in the development and application of statistical models and bioinformatics methodologies as applied to the analysis of animal model discoveries. These analyses will be used for validation purposes as well as in the refinement of existing models. Specifically, faculty within the BDMC will build flexible predictive models using multiple clinical data sources in order to identify and prioritize LOAD risk alleles, and to analyze gene expression profiles, proteomics, and metabolomics data for implementation in animal models. They will also develop and apply efficient sequential testing designs for testing identified mouse models, and use robust post-hoc subgroup identification methods for assessing potential subpopulation heterogeneity in the effect of globally non- efficacious candidate therapies. The end result will allow the BDMC to identify and validate translatable biomarkers that can ultimately assist in clinico-pathological staging of an AD-like disease progression in AD animal models.
总结

项目成果

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Daniel L Gillen其他文献

Daniel L Gillen的其他文献

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{{ truncateString('Daniel L Gillen', 18)}}的其他基金

Statistical Methods for Alzheimer's Research
阿尔茨海默病研究的统计方法
  • 批准号:
    10522647
  • 财政年份:
    2022
  • 资助金额:
    $ 27.81万
  • 项目类别:
Recruiting and retaining participants from disadvantaged neighborhoods in registries
在登记处招募和留住弱势社区的参与者
  • 批准号:
    10614609
  • 财政年份:
    2022
  • 资助金额:
    $ 27.81万
  • 项目类别:
Recruiting and retaining participants from disadvantaged neighborhoods in registries
在登记处招募和留住弱势社区的参与者
  • 批准号:
    10447533
  • 财政年份:
    2022
  • 资助金额:
    $ 27.81万
  • 项目类别:
Core C-Data Management & Statistics Core
核心 C 数据管理
  • 批准号:
    10188383
  • 财政年份:
    2020
  • 资助金额:
    $ 27.81万
  • 项目类别:
Core C-Data Management & Statistics Core
核心 C 数据管理
  • 批准号:
    10378029
  • 财政年份:
    2020
  • 资助金额:
    $ 27.81万
  • 项目类别:
Core C-Data Management & Statistics Core
核心 C 数据管理
  • 批准号:
    9922102
  • 财政年份:
    2020
  • 资助金额:
    $ 27.81万
  • 项目类别:
Core C-Data Management & Statistics Core
核心 C 数据管理
  • 批准号:
    10582628
  • 财政年份:
    2020
  • 资助金额:
    $ 27.81万
  • 项目类别:
The study partner requirement in preclinical Alzheimers disease trials
阿尔茨海默病临床前试验中研究伙伴的要求
  • 批准号:
    9373717
  • 财政年份:
    2017
  • 资助金额:
    $ 27.81万
  • 项目类别:
Neuroimaging biomarkers for cognitive decline in elderly with amyloid pathology
淀粉样蛋白病理老年人认知能力下降的神经影像生物标志物
  • 批准号:
    10160735
  • 财政年份:
    2017
  • 资助金额:
    $ 27.81万
  • 项目类别:
Neuroimaging biomarkers for cognitive decline in elderly with amyloid pathology
淀粉样蛋白病理老年人认知能力下降的神经影像生物标志物
  • 批准号:
    9311342
  • 财政年份:
    2017
  • 资助金额:
    $ 27.81万
  • 项目类别:
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