Neurochemical and metabolomic studies of the cortical GABAergic system

皮质 GABA 能系统的神经化学和代谢组学研究

• 批准号: nhmrc : 568767
• 负责人: A/Pr Vladimir Balcar
• 金额: $ 18.84万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/neurochemical-metabolomic-studies-cortical-gabaergic/76755
• 关键词: Neurochemical; metabolomic; studies; cortical; GABAergic

This work will use targeted neuropharmacology, systems analysis and multivariate statistics to provide a unique perspective on detailed aspects of the organization and function of the GABAergic system in the brain, as well as the mode of action of the drug of abuse GHB. This will have broad benefits for a wide range of disorders, including sleep disorders, pain and epilepsy as well as providing clearer targets for drug development.

这项工作将使用有针对性的神经药理学、系统分析和多元统计，以提供关于大脑中GABA能系统的组织和功能的详细方面的独特视角，以及滥用药物GHB的作用模式。这将为包括睡眠障碍、疼痛和癫痫在内的各种疾病带来广泛的好处，并为药物开发提供更明确的靶点。