Neural Basis of Resting-State Functional Connectivity
静息态功能连接的神经基础
基本信息
- 批准号:9418286
- 负责人:
- 金额:$ 24.9万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-04-01 至 2020-03-31
- 项目状态:已结题
- 来源:
- 关键词:AnimalsApplications GrantsArousalBehavioralBrainBrain DiseasesClinical ResearchCommunicationDataDiseaseDrowsinessElectrocorticogramElectroencephalographyElectrophysiology (science)EventFrequenciesFunctional Magnetic Resonance ImagingFunctional disorderFutureGoalsHealthHeart RateHumanKnowledgeLaboratoriesLeadLearningLightLinkMacacaMapsMeasurementMeasuresMediatingMentorsMissionModalityNatureNeurosciences ResearchPathologicPathologyPatternPhysiologyPositioning AttributeProcessPublic HealthResearchResearch PersonnelRestRoleSignal TransductionSleepSpeedTechniquesTestingTimeTrainingUnited States National Institutes of HealthVariantWorkWritinganalytical methodawakebasebehavior measurementclinical biomarkersdisabilityexperienceexperimental studyimprovedinnovationinsightmultimodalityneural correlatenovelprogramspublic health relevancerelating to nervous systemrespiratoryspatiotemporaltoolvigilance
项目摘要
DESCRIPTION (provided by applicant): Resting-state functional magnetic resonance imaging (rsfMRI) has been widely used to map large-scale brain networks and their pathological changes under with various brain diseases. Although a neural basis for the rsfMRI signals has been established with electrophysiological studies, the nature of the underlying neural correlates remains largely unknown. The lack of understanding of the specific neural correlates and generative mechanisms of rsfMRI network correlations hampers their interpretation. The overall goal of the proposed research is to elucidate specific neural correlates and generative mechanisms that lead to rsfMRI signal correlations. The research objective will be achieved through two specific aims: Aim 1 is to elucidate the neural correlate and generative mechanism of region-specific correlations in resting-state signals with using large-scale electrophysiologica recordings and concurrent fMRI-electrophysiological measurements. Aim 2 is to identify specific electrophysiological events that contribute to global, spatially non-specific fMRI correlations and
clarify their link to the brain's vigilance level, also using multi-modal approach. The proposed research is innovative, because it will be the first attempt to deconstruct rsfMRI correlations int two core components, each with a mechanism that can be characterized on electrophysiological grounds. The impact of this research is highly significant, because the identification of distinct electrophysiological contributions to rsfMRI signals will improve the understanding of functional networks and help interpret the relationship between abnormalities in networks and pathology.
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Xiao Liu其他文献
Three-dimensional printing of $$\varvec{\upbeta }$$ -tricalcium phosphate/calcium silicate composite scaffolds for bone tissue engineering
- DOI:
10.1007/s42242-018-0010-5 - 发表时间:
2018-05-21 - 期刊:
- 影响因子:7.600
- 作者:
Yifan Dong;Haibo Duan;Naru Zhao;Xiao Liu;Yijuan Ma;Xuetao Shi - 通讯作者:
Xuetao Shi
Xiao Liu的其他文献
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{{ truncateString('Xiao Liu', 18)}}的其他基金
Multimodal study of infra-slow propagating brain activity
亚慢速传播大脑活动的多模态研究
- 批准号:
10012212 - 财政年份:2020
- 资助金额:
$ 24.9万 - 项目类别:
The role of brain arousal in resting-state functional MRI
大脑唤醒在静息态功能 MRI 中的作用
- 批准号:
10252780 - 财政年份:2020
- 资助金额:
$ 24.9万 - 项目类别:
The role of brain arousal in resting-state functional MRI
大脑唤醒在静息态功能 MRI 中的作用
- 批准号:
10474394 - 财政年份:2020
- 资助金额:
$ 24.9万 - 项目类别:
The role of brain arousal in resting-state functional MRI
大脑唤醒在静息态功能 MRI 中的作用
- 批准号:
10682539 - 财政年份:2020
- 资助金额:
$ 24.9万 - 项目类别: