Neural circuits for cognitive control

项目总结 行为的灵活性是智力的一个关键和无处不在的组成部分。大脑会根据具体情况以不同的方式来控制我们的行为。额叶皮质在灵活和适应性行为中起着基础性的作用，但人们对这种认知控制的机制知之甚少，而且经常在决定如何解释相互冲突的信息集的背景下进行研究。在这项提议中，我们的目标是通过利用一个难得的机会直接侵入性地研究人脑中的神经信号，来系统地研究在多个不同场景和任务中是否存在潜在的认知控制的不变计算。此外，我们的目标是采取初步步骤，通过对潜在电路的侵入性电刺激来干扰这种认知控制信号。

Project summary Flexibility in behavior is a critical and ubiquitous component of intelligence. The brain adapts to control our behavior in different ways depending on the specific situation. Frontal cortex plays a fundamental role in flexible and adaptive behavior but the mechanisms underlying such cognitive control are poorly understood and are often studied in the context of deciding how to interpret conflicting sets of information. In this proposal we aim to systematically investigate whether there are invariant computations underlying cognitive control across multiple different scenarios and tasks by taking advantage of a rare opportunity to invasively and directly investigate the neural signals in the human brain. Furthermore, we aim to take initial steps towards interfering with such cognitive control signals via invasive electrical stimulation of the underlying circuits.