Insulin Resistance and Breast Cancer Prognosis in Black & White Women
黑人的胰岛素抵抗和乳腺癌预后
基本信息
- 批准号:9294967
- 负责人:
- 金额:$ 52.51万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-07-09 至 2020-04-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAdjuvantAffectAfrican AmericanAggressive behaviorAnimal ModelBlood specimenBreast Cancer Risk FactorCancer PatientCancer PrognosisCell ProliferationCessation of lifeDiabetes MellitusDiseaseDistantEpidemicEvaluationExcisionExhibitsGoalsGrowthGrowth FactorHormone ReceptorHyperinsulinismImmunohistochemistryIncidenceInsulinInsulin ReceptorInsulin ResistanceInsulin-Like Growth Factor IInsulin-Like Growth Factor ReceptorInsulin-Like-Growth Factor I ReceptorLinkLiteratureMammary NeoplasmsMeasuresMediatingMetabolic syndromeMetforminMinorityMusNewly DiagnosedNon-Insulin-Dependent Diabetes MellitusObesityOperative Surgical ProceduresOutcomePathway interactionsPatient RecruitmentsPatientsPatternPeripheralPopulationProcessRaceRandomized Controlled TrialsReceptor SignalingRecruitment ActivityRecurrenceReportingResearchRiskRoleSamplingSignal PathwaySignal TransductionTestingTissuesWomanWorkbreast cancer diagnosisbreast cancer survivalcancer subtypescancer therapycell growthdiabeticepidemiology studyimprovedinsulin signalingmalignant breast neoplasmmortalitynew therapeutic targetnon-diabeticoutcome forecastprognosticracial differenceracial disparityscreeningtargeted cancer therapytargeted treatmenttumor
项目摘要
DESCRIPTION (provided by applicant): Despite improvements in breast cancer diagnosis and treatment, Black women with breast cancer continue to have a worse prognosis than White women. The purpose of this study is to determine whether differences in insulin resistance can explain in part the disparities in breast cancer survival between Black and White women. Insulin resistance is an important component of obesity, the metabolic syndrome and early stage type 2 diabetes, conditions associated with more aggressive breast cancer subtypes and increased mortality. Higher insulin levels in White women have also been associated with increased breast cancer mortality, although this has not been studied in Black women. Given that obesity and diabetes epidemics disproportionately affect minority populations, it is important understand the relationship of hyperinsulinemia, a result of obesity, insulin resistance and increased IR signaling on the progression of breast cancer. Understanding these relationships could explain the different patterns of disease seen in different racial groups and help to identify patients who
would benefit from targeted therapy. Our research attempts to address some of these gaps in the literature. We have 2 main aims: Aim 1: To examine whether the association between peripheral insulin resistance and breast cancer with a poor prognosis differs between black and white women. Aim 2: To demonstrate whether the tumor's insulin receptor and / or IGF-1 receptor signaling pathway is associated with poor prognostic features and whether activation of this pathway differs between black and white women. We will recruit 936 white women and 350 black women with a newly diagnosed breast cancer, to investigate the links between insulin resistance, breast cancer aggression, and race. Measures of insulin resistance, the metabolic syndrome and obesity will be collected to investigate whether insulin is a key mechanistic link in the association between obesity and breast cancer aggressivity, and how race affects this association. Blood samples for insulin resistance and anthropometric measures will be taken during the pre-operative evaluation of women with a new primary breast cancer. Samples of breast cancer tissue removed during primary surgical resection will be examined using immunohistochemistry to assess the role of insulin, insulin-like disparities in breast cancer prognosis between racial groups.
描述(由申请人提供):尽管乳腺癌诊断和治疗取得了进步,但患有乳腺癌的黑人女性的预后仍然比白人女性更差。本研究的目的是确定胰岛素抵抗的差异是否可以部分解释黑人和白人女性乳腺癌生存率的差异。胰岛素抵抗是肥胖、代谢综合征和早期 2 型糖尿病、与更具侵袭性的乳腺癌亚型和死亡率增加相关的疾病的重要组成部分。白人女性较高的胰岛素水平也与乳腺癌死亡率增加有关,尽管尚未在黑人女性中进行研究。鉴于肥胖和糖尿病流行对少数群体的影响尤为严重,了解高胰岛素血症(肥胖、胰岛素抵抗和 IR 信号增强导致的乳腺癌进展)之间的关系非常重要。了解这些关系可以解释不同种族群体中所见的不同疾病模式,并有助于识别患有哪些疾病的患者
将受益于靶向治疗。我们的研究试图解决文献中的一些空白。我们有 2 个主要目标: 目标 1:研究黑人和白人女性外周胰岛素抵抗与预后不良的乳腺癌之间的关联是否存在差异。目标 2:证明肿瘤的胰岛素受体和/或 IGF-1 受体信号通路是否与不良预后特征相关,以及该通路的激活在黑人和白人女性之间是否存在差异。我们将招募 936 名新诊断出乳腺癌的白人女性和 350 名黑人女性,以调查胰岛素抵抗、乳腺癌侵袭性和种族之间的联系。将收集胰岛素抵抗、代谢综合征和肥胖的测量结果,以研究胰岛素是否是肥胖和乳腺癌侵袭性之间关联的关键机制联系,以及种族如何影响这种关联。在对患有新原发性乳腺癌的女性进行术前评估期间,将采集胰岛素抵抗的血样和人体测量指标。将使用免疫组织化学检查初次手术切除期间取出的乳腺癌组织样本,以评估胰岛素的作用以及胰岛素样差异在种族群体之间乳腺癌预后中的差异。
项目成果
期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Nina A. Bickell其他文献
P099 Helpful and Challenging Aspects of Family Member Involvement in Goals of Care Conversations
- DOI:
10.1016/j.jpainsymman.2016.10.185 - 发表时间:
2016-12-01 - 期刊:
- 影响因子:
- 作者:
Dena Schulman-Green;Jenny L. Lin;Cardinale B. Smith;Shelli L. Feder;Nina A. Bickell - 通讯作者:
Nina A. Bickell
P107 Patient and Physician Views About Family Involvement in Goals of Care Conversations
- DOI:
10.1016/j.jpainsymman.2016.10.192 - 发表时间:
2016-12-01 - 期刊:
- 影响因子:
- 作者:
Jenny J. Lin;Cardinale B. Smith;Shelli Feder;Nina A. Bickell;Dena Schulman-Green - 通讯作者:
Dena Schulman-Green
Nina A. Bickell的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Nina A. Bickell', 18)}}的其他基金
DiSRUPT: Dismantling Structural Racism Underlying the Organization of Ambulatory PracTices: an observational study of clinical desegregation
DiSRUPT:消除门诊实践组织中的结构性种族主义:临床废除种族隔离的观察性研究
- 批准号:
10474861 - 财政年份:2022
- 资助金额:
$ 52.51万 - 项目类别:
DiSRUPT: Dismantling Structural Racism Underlying the Organization of Ambulatory PracTices: an observational study of clinical desegregation
DiSRUPT:消除门诊实践组织中的结构性种族主义:临床废除种族隔离的观察性研究
- 批准号:
10650244 - 财政年份:2022
- 资助金额:
$ 52.51万 - 项目类别:
Comparative Modeling for the Prevention and Control of Uterine Cancer
子宫癌预防和控制的比较模型
- 批准号:
10331235 - 财政年份:2021
- 资助金额:
$ 52.51万 - 项目类别:
Comparative Modeling for the Prevention and Control of Uterine Cancer
子宫癌预防和控制的比较模型
- 批准号:
10704680 - 财政年份:2021
- 资助金额:
$ 52.51万 - 项目类别:
Comparative Modeling for the Prevention and Control of Uterine Cancer
子宫癌预防和控制的比较模型
- 批准号:
10489814 - 财政年份:2021
- 资助金额:
$ 52.51万 - 项目类别:
Insulin Resistance and Breast Cancer Prognosis in Black & White Women
黑人的胰岛素抵抗和乳腺癌预后
- 批准号:
8720255 - 财政年份:2012
- 资助金额:
$ 52.51万 - 项目类别:
Insulin Resistance and Breast Cancer Prognosis in Black & White Women
黑人的胰岛素抵抗和乳腺癌预后
- 批准号:
8396307 - 财政年份:2012
- 资助金额:
$ 52.51万 - 项目类别:
相似海外基金
Metachronous synergistic effects of preoperative viral therapy and postoperative adjuvant immunotherapy via long-term antitumor immunity
术前病毒治疗和术后辅助免疫治疗通过长期抗肿瘤免疫产生异时协同效应
- 批准号:
23K08213 - 财政年份:2023
- 资助金额:
$ 52.51万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Improving the therapeutic immunity of cancer vaccine with multi-adjuvant polymeric nanoparticles
多佐剂聚合物纳米粒子提高癌症疫苗的治疗免疫力
- 批准号:
2881726 - 财政年份:2023
- 资助金额:
$ 52.51万 - 项目类别:
Studentship
Evaluation of the Sensitivity to Endocrine Therapy (SET ER/PR) Assay to predict benefit from extended duration of adjuvant endocrine therapy in the NSABP B-42 trial
NSABP B-42 试验中内分泌治疗敏感性 (SET ER/PR) 测定的评估,用于预测延长辅助内分泌治疗持续时间的益处
- 批准号:
10722146 - 财政年份:2023
- 资助金额:
$ 52.51万 - 项目类别:
Countering sympathetic vasoconstriction during skeletal muscle exercise as an adjuvant therapy for DMD
骨骼肌运动期间对抗交感血管收缩作为 DMD 的辅助治疗
- 批准号:
10735090 - 财政年份:2023
- 资助金额:
$ 52.51万 - 项目类别:
AUGMENTING THE QUALITY AND DURATION OF THE IMMUNE RESPONSE WITH A NOVEL TLR2 AGONIST-ALUMINUM COMBINATION ADJUVANT
使用新型 TLR2 激动剂-铝组合佐剂增强免疫反应的质量和持续时间
- 批准号:
10933287 - 财政年份:2023
- 资助金额:
$ 52.51万 - 项目类别:
DEVELOPMENT OF SAS A SYNTHETIC AS01-LIKE ADJUVANT SYSTEM FOR INFLUENZA VACCINES
流感疫苗类 AS01 合成佐剂系统 SAS 的开发
- 批准号:
10935776 - 财政年份:2023
- 资助金额:
$ 52.51万 - 项目类别:
DEVELOPMENT OF SMALL-MOLECULE DUAL ADJUVANT SYSTEM FOR INFLUENZA VIRUS VACCINE
流感病毒疫苗小分子双佐剂体系的研制
- 批准号:
10935796 - 财政年份:2023
- 资助金额:
$ 52.51万 - 项目类别:
A GLYCOLIPID ADJUVANT 7DW8-5 FOR MALARIA VACCINES
用于疟疾疫苗的糖脂佐剂 7DW8-5
- 批准号:
10935775 - 财政年份:2023
- 资助金额:
$ 52.51万 - 项目类别:
Adjuvant strategies for universal and multiseasonal influenza vaccine candidates in the context of pre-existing immunity
在已有免疫力的情况下通用和多季节流感候选疫苗的辅助策略
- 批准号:
10649041 - 财政年份:2023
- 资助金额:
$ 52.51万 - 项目类别:
Adjuvant Photodynamic Therapy to Reduce Bacterial Bioburden in High-Energy Contaminated Open Fractures
辅助光动力疗法可减少高能污染开放性骨折中的细菌生物负载
- 批准号:
10735964 - 财政年份:2023
- 资助金额:
$ 52.51万 - 项目类别:














{{item.name}}会员




