MIDAS Center for Communicable Disease Dynamics
MIDAS 传染病动态中心
基本信息
- 批准号:9335878
- 负责人:
- 金额:$ 225万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-09-15 至 2019-08-31
- 项目状态:已结题
- 来源:
- 关键词:AcademiaAccountingAchievementAddressAntibiotic ResistanceBiologicalCar PhoneCollaborationsCommunicable DiseasesComputer SimulationDataData SourcesDevelopmentDisciplineDoseDrug resistanceEducation and OutreachEmerging Communicable DiseasesEpidemiologyEvolutionFoundationsFundingGeneticGenetic RecombinationGenomicsGonorrheaHeterogeneityInfectionInterventionJournalismKnowledgeMalariaMapsMathematicsMeasuresMediatingMethodologyMethodsModelingPeer ReviewPneumococcal InfectionsPoliciesPopulationPrevalencePublic HealthPublic Health SchoolsPublicationsReadinessRecruitment ActivityResearchResearch ActivityResearch InfrastructureRiskRouteSeveritiesSourceStatistical ModelsTestingTimeTrainingTuberculosisVaccinesVirusWorkanalytical methoddisease transmissionmathematical modelnext generationpathogenpublic health emergencyresistance mechanismresponsesoftware developmenttheoriestransmission process
项目摘要
We propose a competing renewal of the MIDAS Center for Communicable Disease Dynamics (CCDD) at
Harvard School of Public Health. Building on a four-year record of over 170 peer-reviewed publications and
significant achievements in outreach and education, we propose a multipronged approach to extend the
activities of this Center of Excellence into the next funding period. Combining expertise in mathematical and
statistical modeling of infection with related disciplines, we will undertake methodologic development and
application to a range of public health problems. Project I. Pathogen Genomics and Evolution develops
computational and statistical models to infer local and global transmission and clustering of infections,
antigenic change by recombination, and evolution under vaccine-mediated selection. Project II. New Analytic
Methods for New Data Sources develops and tests statistical approaches for interpreting participatory
surveillance and mobile phone data for parameterization and testing of transmission-dynamic models, uses
hydrological modeling to build risk maps for malaria, and develops the statistical theory of negative controls.
Project III. Accounting for Measured and Unmeasured Heterogeneity in Host Populations proposes a variety
of studies to assess the contribution of host heterogeneity to model parameter estimation for infections with
different transmission routes and creates models incorporrating two key sources of such heterogeneity: virus
interference and dose-response relationships. Project IV. Understanding and Controlling Antibiotic
Resistance studies drug resistance in gonorrhea, tuberculosis, and pneumococcal infections, applying
methods from earlier projects to understand the genetic and selective origins of resistance and the
mechanisms underlying observed heterogeneities in its prevalence. Project V. Collaborative Modeling for
Assessment and Optimization in Public Health proposes work with public health partners to address two key
aspects of their work ~ burden/severity estimation and optimization of interventions - using a range of
modeling approaches. Software development and sharing and Policy Studies are integral parts of our
research activities. In Outreach and Education we propose an ambitious set of initiatives aimed at pipeline
and recruiting, training the next generation of modelers, and engaging colleagues in policy, academia and
journalism.
我们建议对MIDAS传染病动力学中心(CCDD)进行竞争性更新
项目成果
期刊论文数量(0)
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MARC LIPSITCH其他文献
MARC LIPSITCH的其他文献
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{{ truncateString('MARC LIPSITCH', 18)}}的其他基金
Methodological Approaches to Planning and Analysis of N*
N* 规划和分析的方法论
- 批准号:
7028724 - 财政年份:2006
- 资助金额:
$ 225万 - 项目类别:
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