2017 RNA Editing Gordon Research Conference and Gordon Research Seminar

2017年RNA编辑戈登研究大会暨戈登研究研讨会

• 批准号: 9331005
• 负责人: Reuben S Harris
• 金额: $ 0.3万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-03-03 至 2018-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9331005
• 关键词: Address; Advocate; Area; Autoimmune Diseases; Bioinformatics; Biological Process; Biology; Brain; California; Chemicals; Collaborations; Communicable Diseases; Cytosine; DNA; DNA Modification Process; Deamination; Defect; Disease; Enzymes; Event; Evolution; Female; Fostering; Gene Expression Regulation; Generations; Genetic Code; Growth; Health; Hour; Human; Immunity; Immunologic Deficiency Syndromes; International; Learning; Malignant Neoplasms; Malignant lymphoid neoplasm; Mediating; Mental disorders; Mentors; Metabolism; Mission; Modification; Molecular; Molecular Machines; Mothers; Mutagenesis; Oral; Organism; Oxygenases; Postdoctoral Fellow; Process; RNA; RNA Editing; RNA Interference; Regulation; Research; Research Personnel; Science; Scientist; Students; Technology; Time; Training; Transfer RNA; Underrepresented Minority; Woman; adaptive immunity; antiviral immunity; apoB mRNA editing catalytic subunit; cancer genome; career; career development; design; epigenomics; interdisciplinary collaboration; lectures; meetings; minority scientist; multidisciplinary; nervous system disorder; next generation; next generation sequencing; novel; peer; posters; programs; social; symposium; transcriptome; tumor progression

PROJECT SUMMARY / ABSTRACT RNA and DNA undergo a wide variety of programmed chemical modifications in all organisms, and these changes are essential for many biological processes including metabolism, gene regulation, brain function, immunity, and evolution. Defects in these processes manifest as disease states including cancer, neurological diseases, immunodeficiency syndromes, and infectious diseases. While different molecular machines are responsible for generating the large and diverse repertoire of modifications in any given organism, the researchers investigating these processes routinely encounter similar theoretical and technical challenges. Thus, there is a strong need to foster a meeting among researchers at the forefront of this broad area in order to overcome these hurdles and promote a deeper understanding of the underlying biology and resulting disease processes. The biennial RNA Editing Gordon Research Conference (GRC) is the only international meeting devoted to this mission. The 2017 meeting has three major aims. Aim 1 will be showcasing the latest research on editing and modification mechanisms and technologies that impact human health. This aim will be accomplished through 9 oral sessions with >60 talks including a keynote lecture by a Nobel Laureate, as well as through 4 poster sessions with >75 poster presentations. The program is organized to maximize discussion, learning, mentoring, and networking opportunities. Aim 2 will be creating opportunities for new and impactful collaborations to develop between established investigators in editing and modification field and new investigators and/or established investigators who are new to this area. This aim will be accomplished by providing opportunities for formal and informal discussions. Formal discussions will follow all talks, and informal discussions will occur during breaks, meals, open afternoons, poster sessions, and evening social periods. Aim 3 will be providing presentation, mentoring, and career development opportunities for all student, post-doctoral, and under-represented trainees, who are destined to become the leaders of the next scientific generation. This will be accomplished by holding a one and half day Gordon Research Seminar (GRS) for student and postdoctoral trainees prior to the GRC. The GRS will have 12 oral presentations and >25 poster presentations, as well as a career development keynote by a pioneer in the modification field. The GRS will provide a dedicated forum for student and postdoctoral trainees to present and discuss research and network with peers before participating in the GRC. This important event helps trainees to become relaxed and prepared to engage and learn from senior mentors during the GRC. Additionally, the GRC will also feature an educational opportunity called the Power Hour, which addresses the unique challenges faced by women in science. This novel event will be hosted by a leader in the RNA Editing field and an advocate for women in science. Overall, this biennial meeting is vital for the continued growth and advancement of the editing and modification fields, the cross-pollination of other fields, and the training of the next generation of scientists.

项目概要/摘要 RNA 和 DNA 在所有生物体中都会经历各种各样的程序化化学修饰，而这些修饰 变化对于许多生物过程至关重要，包括新陈代谢、基因调控、大脑功能、 免疫和进化。这些过程中的缺陷表现为疾病状态，包括癌症、神经系统疾病 疾病、免疫缺陷综合症和传染病。虽然不同的分子机器 负责在任何给定的有机体中产生大量多样的修饰， 研究这些过程的研究人员经常遇到类似的理论和技术挑战。 因此，迫切需要在这一广泛领域的前沿研究人员之间建立一次会议，以便 克服这些障碍并促进对基础生物学和由此产生的更深入的了解 疾病过程。两年一度的RNA编辑戈登研究会议（GRC）是唯一的国际性会议 专门讨论这一使命的会议。 2017年会议有三大目标。目标1将展示最新的 研究影响人类健康的编辑和修改机制和技术。这个目标将是 通过 9 场口头会议和超过 60 场演讲（包括诺贝尔奖获得者的主题演讲）完成 通过 4 场海报会议，进行超过 75 场海报展示。该计划的组织目的是最大限度地讨论， 学习、指导和交流机会。目标 2 将为新的、有影响力的人创造机会 编辑和修改领域的现有研究人员与新研究人员之间发展合作 对该领域不熟悉的调查员和/或已建立的调查员。这一目标将通过以下方式实现 提供正式和非正式讨论的机会。所有会谈之后将进行正式讨论，非正式讨论 讨论将在休息、用餐、下午开放、海报会议和晚间社交时段进行。目的 3 将为所有学生、博士后、 以及代表性不足的受训者，他们注定会成为下一代科学的领导者。这 将通过为学生和学生举办为期一天半的戈登研究研讨会（GRS）来完成 GRC 之前的博士后实习生。 GRS 将有 12 场口头演讲和超过 25 场海报演讲， 以及改装领域先驱的职业发展主题演讲。 GRS 将提供 专门为学生和博士后实习生提供的论坛，展示和讨论研究成果并与同行建立联系 在参加 GRC 之前。这项重要的活动可以帮助学员放松并做好准备 在 GRC 期间与资深导师互动并向他们学习。此外，GRC 还将设有教育设施 名为“Power Hour”的机会，旨在解决科学界女性面临的独特挑战。这 新颖的活动将由 RNA 编辑领域的一位领导者和科学界女性的倡导者主持。全面的， 这次两年一次的会议对于编辑和修改领域的持续发展和进步至关重要， 其他领域的异花授粉，以及下一代科学家的培训。