A Personal, Nonobtrusive System for Tracking Arterial Blood Pressure

用于跟踪动脉血压的个人非侵入式系统

• 批准号: 9410363
• 负责人: Vladimir Shusterman
• 金额: $ 53.5万
• 依托单位: PINMED, INC.
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-10 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9410363
• 关键词: Accelerometer; Algorithms; American; Arterial Lines; Awareness; Blood Pressure; Blood Pressure Monitors; Calibration; Cardiac; Cardiology; Cardiovascular Diseases; Cardiovascular system; Central Artery; Chronic; Clinical; Clinics and Hospitals; Collaborations; Computer software; Data; Data Quality; Detection; Devices; Diagnosis; Electrocardiogram; Electromagnetics; Epidemic; Expert Systems; Goals; Growth; Home environment; Hour; Human; Hypertension; Iowa; Letters; Life; Life Style; London; Manuals; Measurement; Medical; Medical center; Medicine; Monitor; Organ; Outcome; Participant; Patients; Penetration; Performance; Phase; Physicians; Property; Quality Indicator; Signal Transduction; Sleep; System; Technology; Testing; Time; Training; Universities; aging population; base; cardiovascular risk factor; commercialization; cost; human subject; implantable device; improved; instrumentation; interest; monitoring device; patient population; pressure; prevent; programs; prototype; sensor

PROJECT SUMMARY/ABSTRACT Impact: Over 40 million Americans suffer from hypertension. Timely diagnosis and control of high arterial blood pressure (AP) are crucial for preventing life-threatening complications and end-organ damage but have been hampered by the lack of nondisruptive monitors for 24-hour (including essential nighttime) AP tracking. Due to the epidemic proportions of AP abnormalities, an unobtrusive, cuff-free AP monitor will have a significant, lasting impact on the lives of millions of Americans, particularly those with cardiovascular risk factors and chronic cardiovascular diseases. Background: In Phase 1, we developed a working prototype of the AP Expert (APEX), a system for nonobtrusive (cuff-free) tracking of the AP waves in central arteries using a multisensor array and personalized calibration. The system was tested alongside a clinical oscillometric system in 30 human subjects and met the requirements of the AAMI standards, surpassing the accuracy of several commercial systems. In addition, the signal quality was tested in overnight studies in a real-life setting (at home) and found acceptable for AP tracking. Goal: The goal of Phase 2 of this project is to refine the prototype system for nonobtrusive AP tracking and to test it in larger human studies. In Aim 1, the system’s overnight performance in the course of sleep studies will be tested. In Aim 2, the system’s performance will be tested alongside a standard intra-arterial line in cardiac ICU (CICU) patients to determine optimal number of calibration points and to refine the signal-processing algorithm based on these data. In Aim 3, the prototype will be further refined to improve the sensors’ durability, performance and form factor. The expected outcome of Phase 2 is a clinical-grade, mobile system for nighttime AP tracking.

项目总结/摘要 影响：超过4000万美国人患有高血压。及时诊断和控制高动脉血 压力（AP）对于预防危及生命的并发症和终末器官损伤至关重要， 由于缺乏24小时（包括必要的夜间）AP跟踪的无中断监视器，由于 AP异常的流行比例，一个不显眼的，无袖带的AP监测器将具有显著的， 对数百万美国人的生活产生持久影响，特别是那些有心血管风险因素的人， 慢性心血管疾病 背景：在第一阶段，我们开发了一个AP专家（APEX）的工作原型， 使用多传感器阵列和个性化的非侵入性（无袖带）跟踪中央动脉中的AP波 校准在30名人类受试者中，该系统与临床生物计量系统一起进行了测试，并符合 该系统符合AAMI标准的要求，超过了几个商业系统的精度。此外该 信号质量在真实生活环境（在家）的过夜研究中进行了测试，发现AP可以接受 跟踪. 目标：该项目第二阶段的目标是完善非侵入性AP跟踪的原型系统，并 在更大规模的人体研究中进行测试。在目标1中，系统在睡眠研究过程中的夜间性能将 得到考验在目标2中，系统的性能将与心脏中的标准动脉内管路一起进行测试。 ICU（CICU）患者，以确定校准点的最佳数量并完善信号处理 算法基于这些数据。在目标3中，原型将进一步完善，以提高传感器的耐用性， 性能和形状因素。 第2阶段的预期成果是临床级的移动的夜间AP跟踪系统。