DASH-Sodium Trial in Adolescents

青少年 DASH-钠试验

• 批准号: 9424809
• 负责人: Connie Marie Weaver
• 金额: $ 14.9万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9424809
• 关键词: 15 year old; Acid-Base Equilibrium; Address; Adolescence; Adolescent; Adopted; Adult; Age; Agriculture; Aldosterone; American; Asians; Beverages; Blood Pressure; Calcium; Child; Childhood; Cholesterol; Crossover Design; DASH diet; Dairy Products; Diastolic blood pressure; Diet; Diet Habits; Dietary Fiber; Dietary Intervention; Dietary Practices; Domestic Fowls; Dyslipidemias; Effectiveness; Epidemic; Ethnic group; Excretory function; Fatty acid glycerol esters; Female; Fishes; Food Patterns; Future; Guidelines; Height; High Density Lipoprotein Cholesterol; Hispanics; Hormonal; Hypertension; Intake; Intervention; LDL Cholesterol Lipoproteins; Lead; Leadership; Lipids; Low-Density Lipoproteins; Magnesium; Measures; Meat; Medical; Minerals; Morbidity - disease rate; Nuts; Outcome; Participant; Pattern; Plant Roots; Plasma; Policies; Policy Developments; Potassium; Professional Organizations; Randomized; Randomized Controlled Trials; Recommendation; Reporting; Research; Risk Factors; Sampling; Serum; Shapes; Sodium; Subgroup; Testing; Translations; Triglycerides; blood lipid; blood pressure reduction; calcium excretion; cardiovascular health; community setting; dietary approach; efficacy study; experience; feeding; fruits and vegetables; improved; lipid disorder; prevent; primary outcome; protective effect; public health relevance; racial and ethnic; randomized trial; saturated fat; secondary outcome; sex; sugar; summer research; urinary

 DESCRIPTION (provided by applicant): Antecedents of high blood pressure (BP) and dyslipidemia likely originate in childhood. Furthermore, dietary habits developed during adolescence are carried into adulthood. In order to provide evidence in support of dietary guidelines in children and retard the epidemic of BP and dyslipidemia-related morbidity in later years, we propose a carefully controlled, randomized trial to test, among adolescents, two dietary interventions: (1) the Dietary Approaches to Stop Hypertension (DASH) diet, similar to the USDA food patterns for adolescents recommended by the Dietary Guidelines for Americans, and (2) sodium reduction. To this end, we combined the leadership experience of two research groups, Larry Appel and his team who conducted the DASH studies in adults and Connie Weaver and her team from Purdue who have led multiple controlled feeding studies in adolescents. The proposed study is a randomized, 2x2 factorial isocaloric feeding study with a cross-over design that tests the effects on BP and blood lipids of (1) diet (DASH vs Usual) and (2) sodium intake (High vs Low) in a diverse sample of adolescents. Study participants (n=522: ~50% Female; ~25% White, ~25% Black, ~25% Asian, and ~25% Hispanic) will be 11 to 15 years of age with systolic BP in the upper third of the BP distribution for their sex, age and height. Each participant will receive two of the four interventions, each for 25 days, in random order as part of a summer research camp. BP and lipids will be measured at the end of each feeding period. Results of this trial will provide direct evidence of the impact of the two interventions on both blood pressure and blood lipid levels among adolescents. This information will inform dietary guidance and influence future policy development on strategies to lower blood pressure and improve lipid patterns among adolescents. Most importantly, given that the antecedents to CVD risk factors begin in adolescence and track into adulthood, intervening in adolescence has tremendous potential as a means to prevent CVD in adults.