Determining whether sensitivity to the organizing actions of gonadal steroid hormones on memory function and anxiety-related behavior decreases across adolescent development in rats.

确定大鼠青春期发育过程中性腺类固醇激素对记忆功能和焦虑相关行为的组织作用的敏感性是否降低。

• 批准号: 9529970
• 负责人: KALYNN SCHULZ
• 金额: $ 7.55万
• 依托单位: UNIVERSITY OF TENNESSEE KNOXVILLE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-02-05 至 2020-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9529970
• 关键词: Adolescence; Adolescent; Adolescent Development; Adult; Age; Anhedonia; Animal Behavior; Animals; Anxiety; Anxiety Disorders; Behavior; Behavioral; Biological; Biological Models; Biological Testing; Brain; Childhood; Cognitive; Conduct Disorder; Data; Development; Eating Disorders; Emotional; Estradiol; Experimental Designs; Exposure to; Feeling; Female; Future; Goals; Gonadal Steroid Hormones; Hormones; Human; Individual; Investigation; Knowledge; Mediating; Memory; Mental Depression; Mental disorders; Modeling; Nature; Nervous system structure; Neurobiology; Onset of illness; Pattern; Play; Psychopathology; Puberty; Rattus; Reproductive Behavior; Research Design; Risk; Rodent; Role; Sex Bias; Shapes; Short-Term Memory; Social Behavior; Steroids; System; Testing; Testosterone; Time; Work; adolescent brain development; anxiety-related behavior; behavior test; behavioral outcome; behavioral response; boys; cholinergic; design; early experience; emotional behavior; experience; experimental study; girls; innovation; insight; male; mating behavior; nervous system development; neurobiological mechanism; peer; postnatal; predictive modeling; psychosocial; pubertal timing; sex; social; stem; steroid hormone

Adolescence is the period between childhood and adulthood during which cognitive, emotional, and social behaviors develop substantially. As such, adolescence is a period of both opportunity and vulnerability, and mental illness onset typically occurs during adolescence. The factors mediating a successful transition through adolescence range from social to biological. One factor that has received increased investigation in recent years is the timing of puberty. Whether individuals undergo pubertal development early or late relative to their peers increases risk for mental illness. Scientific explanations of the relationship between pubertal timing and mental illness tend to focus on the social and emotional consequences of developing earlier or later than one's peers. However, these models do not consider the role gonadal steroid hormones play in shaping the developing nervous system and behavior. We've proposed that nervous system sensitivity to gonadal steroid hormones decreases across adolescent development. In this framework, the developing adolescent brain is a moving target for the effects of gonadal steroid hormones, and shifts in pubertal timing may alter the course of brain development toward increased vulnerability. The proposed study will test the hypothesis that sensitivity to the organizing actions of gonadal steroid hormones decreases across postnatal development. This hypothesis predicts that adult behavioral outcomes will differ between groups receiving steroid hormone treatments before, during or after the normal time of puberty. Our strategy will be to vary the postnatal age at which rats are exposed to an 18-day period of testosterone (males) or estradiol (females) and then assess anhedonia, working memory, anxiety, and social behavior in adulthood (following hormone replacement). The results of this study will advance our understanding of the neurobiological principles governing adolescent brain development in both males and females. Furthermore, this work will have implications for sex-biased psychopathologies associated with deviations in pubertal timing such as depression, anxiety, and eating disorders.

青春期是从童年到成年之间的一段时期，在此期间，认知、情感、 和社会行为显着发展。因此，青春期是一个充满机会的时期 脆弱性和精神疾病通常发生在青春期。因素 介导青春期从社会到生物的成功过渡。一 近年来受到越来越多研究的因素是青春期的时间。无论 相对于同龄人来说，青春期发育早或晚的个体会增加青春期发育的风险 精神疾病。青春期时间与心理关系的科学解释 疾病往往集中于早期或晚期发展的社会和情感后果 比同龄人。然而，这些模型没有考虑性腺类固醇激素的作用 在塑造发育中的神经系统和行为中发挥作用。我们建议紧张 在青少年发育过程中，系统对性腺类固醇激素的敏感性降低。在 在这个框架中，发育中的青少年大脑是性腺影响的一个移动目标 类固醇激素和青春期时间的变化可能会改变大脑发育的过程 导致脆弱性增加。拟议的研究将检验敏感性的假设 性腺类固醇激素的组织作用在出生后减少 发展。该假设预测成年人的行为结果将在不同年龄之间有所不同 在正常青春期之前、期间或之后接受类固醇激素治疗的群体。 我们的策略是改变大鼠出生后暴露于 18 天的时间的年龄。 睾酮（男性）或雌二醇（女性），然后评估快感缺失、工作记忆、 焦虑和成年后的社交行为（激素替代后）。这样做的结果 研究将增进我们对青少年神经生物学原理的理解 男性和女性的大脑发育。此外，这项工作将对 与青春期时间偏差相关的性别偏见精神病理学，例如抑郁症， 焦虑和饮食失调。