Determining whether sensitivity to the organizing actions of gonadal steroid hormones on memory function and anxiety-related behavior decreases across adolescent development in rats.

确定大鼠青春期发育过程中性腺类固醇激素对记忆功能和焦虑相关行为的组织作用的敏感性是否降低。

• 批准号: 9529970
• 负责人: KALYNN SCHULZ
• 金额: $ 7.55万
• 依托单位: UNIVERSITY OF TENNESSEE KNOXVILLE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-02-05 至 2020-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9529970
• 关键词: Adolescence; Adolescent; Adolescent Development; Adult; Age; Anhedonia; Animal Behavior; Animals; Anxiety; Anxiety Disorders; Behavior; Behavioral; Biological; Biological Models; Biological Testing; Brain; Childhood; Cognitive; Conduct Disorder; Data; Development; Eating Disorders; Emotional; Estradiol; Experimental Designs; Exposure to; Feeling; Female; Future; Goals; Gonadal Steroid Hormones; Hormones; Human; Individual; Investigation; Knowledge; Mediating; Memory; Mental Depression; Mental disorders; Modeling; Nature; Nervous system structure; Neurobiology; Onset of illness; Pattern; Play; Psychopathology; Puberty; Rattus; Reproductive Behavior; Research Design; Risk; Rodent; Role; Sex Bias; Shapes; Short-Term Memory; Social Behavior; Steroids; System; Testing; Testosterone; Time; Work; adolescent brain development; anxiety-related behavior; behavior test; behavioral outcome; behavioral response; boys; cholinergic; design; early experience; emotional behavior; experience; experimental study; girls; innovation; insight; male; mating behavior; nervous system development; neurobiological mechanism; peer; postnatal; predictive modeling; psychosocial; pubertal timing; sex; social; stem; steroid hormone

Adolescence is the period between childhood and adulthood during which cognitive, emotional, and social behaviors develop substantially. As such, adolescence is a period of both opportunity and vulnerability, and mental illness onset typically occurs during adolescence. The factors mediating a successful transition through adolescence range from social to biological. One factor that has received increased investigation in recent years is the timing of puberty. Whether individuals undergo pubertal development early or late relative to their peers increases risk for mental illness. Scientific explanations of the relationship between pubertal timing and mental illness tend to focus on the social and emotional consequences of developing earlier or later than one's peers. However, these models do not consider the role gonadal steroid hormones play in shaping the developing nervous system and behavior. We've proposed that nervous system sensitivity to gonadal steroid hormones decreases across adolescent development. In this framework, the developing adolescent brain is a moving target for the effects of gonadal steroid hormones, and shifts in pubertal timing may alter the course of brain development toward increased vulnerability. The proposed study will test the hypothesis that sensitivity to the organizing actions of gonadal steroid hormones decreases across postnatal development. This hypothesis predicts that adult behavioral outcomes will differ between groups receiving steroid hormone treatments before, during or after the normal time of puberty. Our strategy will be to vary the postnatal age at which rats are exposed to an 18-day period of testosterone (males) or estradiol (females) and then assess anhedonia, working memory, anxiety, and social behavior in adulthood (following hormone replacement). The results of this study will advance our understanding of the neurobiological principles governing adolescent brain development in both males and females. Furthermore, this work will have implications for sex-biased psychopathologies associated with deviations in pubertal timing such as depression, anxiety, and eating disorders.

青春期是介于童年和成年之间的时期，在此期间，认知，情感， 和社会行为的发展。因此，青春期是一个既有机会 和脆弱性，精神疾病通常发生在青春期。的因素 从社会到生物的范围都有。一 近年来，人们越来越多地研究一个因素，那就是青春期的时间。是否 相对于同龄人，青春期发育较早或较晚的个体， 精神疾病青春期时间和心理之间关系的科学解释 疾病往往集中在社会和情感的后果，发展早或晚， 一个人的同龄人。然而，这些模型没有考虑性腺类固醇激素的作用， 在塑造发育中的神经系统和行为中发挥作用。我们建议， 系统对性腺类固醇激素的敏感性在青春期发育过程中降低。在 在这个框架下，发育中的青少年大脑是性腺激素影响的一个移动目标。 类固醇激素和青春期时间的变化可能会改变大脑发育的过程 增加脆弱性。这项拟议的研究将检验敏感性 组织行动的性腺类固醇激素减少， 发展这一假设预测，成年人的行为结果将不同， 在青春期正常时间之前、期间或之后接受类固醇激素治疗的组。 我们的策略将是改变大鼠暴露于18天时间的出生后年龄， 睾酮（男性）或雌二醇（女性），然后评估快感缺乏，工作记忆， 焦虑和成年期的社会行为（激素替代后）。的结果 这项研究将促进我们对支配青少年的神经生物学原理的理解。 男性和女性的大脑发育。此外，这项工作将对以下方面产生影响： 与青春期时间偏差相关的性别偏见精神病理学，如抑郁症， 焦虑和饮食失调