Neurodevelopmental outcome after sevoflurane versus dexmedetomidine/remifentanil anaesthesia in infancy: a randomised controlled trial

婴儿期七氟醚与右美托咪定/瑞芬太尼麻醉后的神经发育结果：一项随机对照试验

• 批准号: nhmrc : GNT1126535
• 负责人: A/Pr Katherine Lee
• 金额: $ 82.58万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/neurodevelopmental-outcome-sevoflurane-controlled-trial/1347557
• 关键词: Neurodevelopmental; outcome; after; sevoflurane; versus

Evidence in animals show that some anaesthetics affect the developing brain. Some human data also show a link between childhood surgery and poorer neurodevelopmental outcome. It is unknown if this association is due to the anaesthetic. Our recent GAS trial showed no evidence for toxicity after 1 hour of anaesthesic but many children have longer anaesthetics. We plan to enrol 420 infants in a study comparing neurodevelopmental outcome after 2 different anaesthetics for surgery lasting >2 hours.

动物实验表明，某些麻醉剂会影响发育中的大脑。一些人类数据也显示，儿童手术与较差的神经发育结果之间存在联系。目前尚不清楚这种关联是否与麻醉剂有关。我们最近的GAS试验显示麻醉1小时后没有毒性的证据，但许多儿童麻醉时间更长。我们计划招募420名婴儿进行一项研究，比较两种不同麻醉持续2小时手术后的神经发育结果。