Interactions of Climate Change on Oceans and Human Health: Assessment of Effects on Ocean Health Related Illness and Disease and Development of Prevention Strategies to Better Protect Public Health

气候变化对海洋和人类健康的相互作用：评估对海洋健康相关疾病的影响以及制定预防策略以更好地保护公众健康

• 批准号: 9789284
• 负责人: Geoffrey Ivan Scott
• 金额: $ 114.59万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9789284
• 关键词: Acidity; Adverse effects; Affect; Anabaena flos-aquae; Antibiotic Resistance; Bacteria; Bacterial Infections; Cause of Death; Chemicals; Chemistry; Climate; Collaborations; Communities; Consumption; Cyanobacterium; Cylindrospermopsis; Development; Disease; Ecosystem; Exposure to; Fresh Water; Goals; Growth; Health; Human; Individual; Infectious Agent; Inflammation; Institution; Investigation; Kinetics; Knowledge; Lead; Marines; Maryland; Microbe; Microbial Biofilms; Microcystis aeruginosa; Minority; Modeling; Nitrogen; Nutrient; Oceans; Organ; Pathogenicity; Phosphorus; Play; Population; Prevention strategy; Process; Production; Public Health; Public Health Schools; Radioisotopes; Recreation; Research; Research Project Grants; Risk; Role; Safety; Saline; Sanitation; Seafood; Shellfish; South Carolina; Surface; Temperature; Toxicology; Toxin; Translating; Universities; Urbanization; Vibrio; Vibrio Infections; Vibrio parahaemolyticus; Vibrio vulnificus; Virulence; Virulent; Water; Wound Infection; Writing; climate change; college; cyanobacterial toxin; design; drinking water; environmental justice; experimental study; exposed human population; field study; future climate scenario; harmful algal blooms; hazard; health assessment; innovation; laboratory experiment; microbial; non-alcoholic; non-alcoholic fatty liver disease; novel; oxidation; predictive modeling; quorum sensing; sea level rise; stressor; symposium; tool

PROJECT SUMMARY The overall goal of the Center for the Assessment and Prediction of the Interactions of Climate Change on Oceans and Human Health (CAPICCOHH or the Center) is to “Enhance our knowledge of the role climate change may play in affecting Vibrio bacterial infections and Cyanobacterial toxin production to develop tools that will inform the public of the associated risks and reduce hazards to risk adverse populations that may be adversely affected”. The effects of climate change including both the individual and interactive effects of increased temperature, altered salinity, and reduced pH (increasing acidity) on Vibrio bacteria (V. vulnificus and V. parahaemolyticus) and Cyanobacteria will be assessed to determine if there are increased in biofilm formation virulence and antibiotic resistance in Vibrio bacteria and increased growth, bloom dynamics and toxin production in Cyanaobacteria that may affect human health and seafood safety in molluscan shellfish. This will involve a combination of multi-factorial lab experiments and field studies to identify climate change- related mechanisms that may increase the virulence and antibiotic resistance of Vibrio bacteria, V. vulnificus and V. parahaemolyticus and bloom dynamics and toxin production of Microcyctin aeruginosa, Cylindrospermopsis raciborkskii and Anabaena flos-aquae. Specifc focus on how salinity alternations may affect Cyanobacterial toxins will be a major focus of these experiments. Chemical studies will focus on determining the role of climate change in moderating microbial quorum sensing and harmful algal bloom toxin production in cultures and natural waters and in development of comprehensive multifactorial models of climate change driven alterations in surface water composition on the kinetics and by-products of harmful algal bloom toxin oxidation in sunlit waters and on sediment surfaces. Also sediment cores from lake bottoms will be analyzed for relic levels of Cyanobacterial toxins and will be dated using radio-isotope to and compared to historical changes in climate. Toxicological investigation of novel biogeochemical transport and transformation of these important infectious agents, Cyanobacterial toxins and microplastics, alone and in mixtures will also be studied, along with potential exposure mechanisms and resulting toxicology in mammalian models and in molluscan shellfish. The interactive effects of both individual and mixture exposures to highly virulent and antibiotic resistant Vibrio bacteria, highly toxic Cyanobacterial toxins and microplastics in water and seafood (molluscan shellfish) will be investigated for adverse effects on organs, inflammation and disease using mammalian models to indicate effects of climate change on human health. These projects will be managed by an Administrative Core (Director and Deputy Director) who will operate the Center on a daily basis and oversee the collaboration and integration of the projects and a Community Engagement Core which will translate technical findings into informational products and forecast that alert the public and better protect public health.

项目概要 气候变化相互作用评估与预测中心的总体目标 海洋与人类健康（CAPICCOHH 或中心）旨在“增强我们对气候作用的认识” 变化可能会影响弧菌细菌感染和蓝藻毒素产生以开发工具 这将告知公众相关风险并减少对可能存在风险的不利人群的危害 不利影响”。气候变化的影响包括个体影响和交互影响 提高温度、改变盐度和降低弧菌 (V. vulnificus) 的 pH 值（增加酸度） 和副溶血弧菌）和蓝藻将被评估以确定生物膜是否增加 弧菌的毒力和抗生素耐药性的形成以及生长、开花动态和 蓝藻产生的毒素可能会影响人类健康和软体动物贝类的海鲜安全。 这将涉及多因素实验室实验和实地研究的结合，以确定气候变化- 可能增加创伤弧菌毒力和抗生素耐药性的相关机制 和副溶血性弧菌以及铜绿微环素的水华动态和毒素产生， Cylindrospermopsis raciborkskii 和 Anabaena flos-aquae。特别关注盐度变化如何影响 影响蓝藻毒素将是这些实验的主要焦点。化学研究将集中于 确定气候变化在调节微生物群体感应和有害藻华毒素方面的作用 文化和自然水域的生产以及综合多因素模型的开发 气候变化驱动地表水成分的变化对有害藻类的动力学和副产品的影响 阳光照射的水域和沉积物表面的水华毒素氧化。湖底的沉积物核心也将被 分析蓝藻毒素的残留水平，并将使用放射性同位素进行测定并与 气候的历史变化。新型生物地球化学转运和转化的毒理学研究 这些重要的传染源、蓝藻毒素和微塑料，无论是单独的还是混合的，也将 以及哺乳动物模型和动物模型中潜在的暴露机制和由此产生的毒理学进行研究 软体动物贝类。个体和混合物暴露于高毒力和毒力的交互作用 水和海鲜中的抗生素耐药性弧菌、剧毒蓝藻毒素和微塑料 （软体动物贝类）将使用以下方法研究对器官、炎症和疾病的不利影响 哺乳动物模型表明气候变化对人类健康的影响。这些项目将由 行政核心（主任和副主任）负责中心的日常运营和监督 项目的协作和整合以及社区参与核心将转化为 将技术发现转化为信息产品和预测，提醒公众并更好地保护公众健康。