Texas Medical Center Training Program in Antimicrobial Resistance

德克萨斯医学中心抗菌素耐药性培训计划

• 批准号: 9790255
• 负责人: Cesar Augusto Arias
• 金额: $ 14.42万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9790255
• 关键词: Antimicrobial Resistance; Medical center; Texas; Training Programs

PROJECT SUMMARY/ABSTRACT The rise of antibiotic-resistant microorganisms globally has become a critical public health priority due to the devastating consequences that it may have to the world health and economy. Indeed, antibiotic resistance threatens the progress of medicine in all areas and, as such, the issue has reached the highest level of government, including the Office of the US President (with the creation of the Presidential Advisory Council on Combating Antibiotic-Resistant Bacteria) and the initiative for global action by the United Nations, among others. Houston is the home to the largest cluster of healthcare institutions in the world, the Texas Medical Center (TMC) with more than 9,200 hospital beds, receiving more than 8 million patient visits per year. Additionally, the Houston area harbors a strong history of outstanding infectious diseases research and training including that focused on antimicrobial resistance (AMR) and antibiotic stewardship. In the last two years, the formation of the UTHealth Center for Antimicrobial Resistance and Microbial Genomics (CARMiG) and the Gulf Coast Consortia (GCC) Cluster for Antimicrobial Resistance (GCC-AMR) has resulted in an active, multidisciplinary and comprehensive research and educational program that has amalgamated the efforts of AMR researchers and created the resources, personnel, funding and fertile ground to launch an ambitious, innovative and unparalleled training program on AMR. We propose to establish the Texas Medical Center Training Program on AMR (TPAMR) that seeks to train postdoctoral scholars, clinical residents and fellows from seven geographically adjacent institutions in the TMC (University of Texas Health Science Center at Houston, MD Anderson Cancer Center, Baylor College of Medicine, University of Texas Medical Branch, Rice University, University of Houston, and Institute of Biosciences and Technology of Texas A&M University) on advanced aspects of AMR research. We aim to take advantage of the strong expertise of the GCC on successful T32 programs in other areas and the educational activities already in place at CARMiG, combined with the expertise of world-class researchers on AMR in the TMC. TPAMR seeks to leverage all the available resources to train the next generation of scientists and clinician-scientists (MDs, PhDs and PharmDs) focused on tackling the pressing AMR public health crisis. The highly collaborative environment provides the perfect opportunity for trainees to acquire the skills, expertise and intellectual abilities to foster innovative research that has a strong translational component and could be developed to directly influence patient care. The focus of expertise of the proposed training grant includes, i) molecular basis of antibiotic resistance, ii) bacterial genomics and bioinformatics, iii) microbiome science, iv) pharmacological aspects of resistance, v) clinical epidemiology and biostatistics of AMR and, vi) antibiotic stewardship. We believe that we are poised to develop a unique, innovative and comprehensive training program that truly provide trainees with exceptional tools and abilities and create a strong cohort of new world-class leaders on AMR.

项目摘要/摘要 全球抗药性微生物的崛起已经成为一个关键的公共卫生优先事项，因为 它可能对世界健康和经济造成毁灭性的后果。事实上，抗生素耐药性 威胁着所有领域的医学进步，因此，这个问题已经达到了 政府，包括美国总统办公室(成立了总统咨询委员会 与抗药性细菌作斗争)和联合国全球行动倡议，其中 其他。休斯顿是世界上最大的医疗机构集群的所在地，德克萨斯医疗 医疗中心(TMC)拥有9,200多张病床，每年接待800多万人次就诊。 此外，休斯顿地区在杰出的传染病研究和培训方面有着悠久的历史。 包括侧重于抗菌素耐药性(AMR)和抗生素管理的报告。在过去的两年里， 成立UTHealth抗菌素耐药性和微生物基因组学中心(CARMiG)和 墨西哥湾沿岸财团(GCC)抗菌素耐药性集群(GCC-AMR)导致了活跃的， 多学科和全面的研究和教育计划，融合了 AMR研究人员并创造了资源、人员、资金和肥沃的土壤，发起了一个雄心勃勃的、 关于AMR的创新和无与伦比的培训计划。我们建议建立德克萨斯医疗中心 AMR培训计划(TPAMR)，旨在培训博士后学者、临床住院医师和研究员 来自TMC(德克萨斯大学健康科学中心)的七个地理上相邻的机构 休斯顿，医学博士安德森癌症中心，贝勒医学院，德克萨斯大学医学分校，赖斯 休斯顿大学和德克萨斯A&M大学生物科学与技术研究所) AMR研究的高级方面。我们的目标是利用GCC在 其他领域的成功T32项目和CARMiG已经到位的教育活动相结合 拥有TMC在AMR方面的世界级研究人员的专业知识。TPAMR寻求利用所有可用的 培训下一代科学家和临床科学家(医学博士、博士和药学博士)的资源 解决迫在眉睫的AMR公共卫生危机。高度协作的环境提供了完美的 为学员提供获得技能、专门知识和智力的机会，以促进创新研究 有很强的转化性成分，可以开发成直接影响患者护理。的关注点 拟议的培训补助金的专门知识包括：一)抗生素耐药性的分子基础；二)细菌 基因组学和生物信息学，三)微生物组科学，四)耐药性的药理学方面，五)临床 AMR的流行病学和生物统计学，以及，vi)抗生素管理。我们相信，我们已经准备好 制定独特、创新和全面的培训计划，真正为学员提供卓越的 工具和能力，并在AMR上打造一支强大的新的世界级领导者队伍。