The Healthy Brain and Child Development National Consortium Administrative Core

项目摘要 神经发育过程是由基因和环境之间的动态相互作用形成的。 生命早期的适应不良经历可以改变发展轨迹，导致有害和持久的 发育后遗症产前和产后危害包括母体物质暴露、有毒物质暴露 在怀孕和生命早期，母亲的健康状况，父母的精神病理学，虐待，结构 种族歧视和过度压力为了阐明各种环境危害如何影响儿童发展， 必须建立生命头10年发展轨迹的规范模板 基于足够大且人口统计学上多样化的美国人口样本。为了实现这一点， 健康大脑和儿童发展国家联合会领导和管理下的研究（六溴环十二烷） 六溴环十二烷国家联盟行政核心（HCAC）将部署一个统一、优化和 一套创新的神经成像（MRI，EEG）措施，辅以广泛的行为， 生理和心理工具，以及生物标本，以了解神经发育轨迹， 在美国各地招募的7,500名母亲和婴儿的样本。六溴环十二烷的总体目标是 创建一个全面，协调和高维数据集，将表征典型的 美国儿童的神经发育轨迹，并将评估生物和环境暴露如何 影响这些轨迹。将特别强调了解产前和产后 接触阿片类药物、大麻、酒精、烟草和/或其他物质。为了实现这些广泛的目标， HCAC将监督研究设计、共同方案的制定，并监测招募情况， 保留，以确保登记的妇女样本包括：1）种族，民族和社会经济 代表美国人群的多样化队列; 2）使用靶向物质的孕妇 （阿片类药物，大麻，酒精，烟草）;和3）人口统计学和行为相似的妇女，没有 怀孕期间使用的物质，以使有效的因果推断。HCAC将确保达到研究目标， 监督业绩，提供培训，制定和执行决策和道德政策，管理 所有研究沟通，并监督考虑研究修改的过程。联同 根据六溴环十二烷国家联盟数据协调中心（HDCC），HCAC将确保大约每年 向更广泛的科学界发布研究数据集。六溴环十二烷国家联盟的研究将为 改善全国儿童健康和发展的公共政策。

PROJECT SUMMARY Neurodevelopmental processes are shaped by dynamic interactions between genes and environments. Maladaptive experiences early in life can alter developmental trajectories, leading to harmful and enduring developmental sequelae. Pre- and postnatal hazards include maternal substance exposure, toxicant exposures in pregnancy and early life, maternal health conditions, parental psychopathology, maltreatment, structural racism, and excessive stress. To elucidate how various environmental hazards impact child development, it is imperative that a normative template of developmental trajectories over the first 10 years of life be established based on a sufficiently large and demographically diverse sample of the US population. To accomplish this, the Healthy Brain and Child Development National Consortium study (HBCD) under the leadership and management of the HBCD National Consortium Administrative Core (HCAC) will deploy a harmonized, optimized, and innovative set of neuroimaging (MRI, EEG) measures complemented by an extensive battery of behavioral, physiological, and psychological tools, and biospecimens to understand neurodevelopmental trajectories in a sample of 7,500 mothers and infants enrolled at sites across the US. The overarching goal of the HBCD is to create a comprehensive, harmonized, and high-dimensional dataset that will characterize typical neurodevelopmental trajectories in US children and that will assess how biological and environmental exposures affect those trajectories. A special emphasis will be placed on understanding the impact of pre- and postnatal exposure to opioids, marijuana, alcohol, tobacco and/or other substances. To address these broad objectives, the HCAC will oversee study design, development of the common protocol, and monitor recruitment and retention to ensure that the sample of women enrolled includes: 1) a racially, ethnically, and socioeconomically diverse cohort that is representative of the US population; 2) pregnant woman with use of targeted substances (opioids, marijuana, alcohol, tobacco); and 3) demographically and behaviorally similar women without substance use in pregnancy to enable valid causal inferences. The HCAC will ensure study objectives are met, monitor performance, provide for training, establish and carry out decision-making and ethical policies, manage all study communications, and oversee processes for considering study modifications. In collaboration with the HBCD National Consortium Data Coordinating Center (HDCC), the HCAC will ensure that approximately annual study datasets are released to the broader scientific community. The HBCD National Consortium study will inform public policy to improve the health and development of children across the nation.