The Healthy Brain and Child Development National Consortium Administrative Core
The Healthy Brain and Child Development National Consortium Administrative Core
批准号:
10380522
负责人:
CHRISTINA CHAMBERS
金额:
$584.0万
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
未结题
起止时间:
2021-09-30 至 2026-06-30
关键词:
10 year oldAccountabilityAddressAdultAffectAlcoholsBehavioralBioinformaticsBiologicalBiological FactorsBirthBrainChildChild DevelopmentChildhoodCohort StudiesCollaborationsCollectionCommunicationCommunitiesComplementComplexConsultationsDNADataData CollectionData Coordinating CenterData SetDecision MakingDevelopmentElectronic Health RecordEnrollmentEnsureEnvironmentEnvironmental ExposureEnvironmental HazardsEnvironmental Risk FactorEpidemiologyEthicsExposure toGenesGoalsHealthInfantInterventionInvestigationLeadershipLegalLifeLinkLocationMapsMarijuanaMaternal HealthMeasuresModalityModificationMonitorMothersOpioidParticipantPerformancePersonal SatisfactionPersonsPhysiologicalPoliciesPopulationPregnancyPregnant WomenProcessProtocols documentationPsychopathologyPublic PolicyPublicationsQuestionnairesReproducibilityResearchResearch DesignResearch PersonnelResource SharingSamplingSiteStandardizationStressStructural RacismTechnologyTimeTobaccoToxicant exposureTrainingUnited States National Institutes of HealthVulnerable PopulationsWomanWorkbasebrain healthcohortcritical perioddata harmonizationdesignearly experienceequity diversity and inclusionexperiencefetal substance exposurehazardhealth disparityhigh dimensionalityhigh riskimprovedinfancyinnovationlongitudinal datasetmagnetic resonance imaging/electroencephalographymaltreatmentmeetingsneurobehavioralneurodevelopmentneuroimagingneurophysiologyperformance sitephysical conditioningpostnatalprenatalprospectivepsychologicracial and ethnicrecruitresiliencesocioeconomicssubstance usesuccesstooltraining opportunitywearable sensor technologywebsite development
中文摘要
项目总结
神经发育过程是由基因和环境之间的动态相互作用塑造的。
生命早期的不良适应经历会改变发育轨迹,导致有害和持久的
发育后遗症。出生前和出生后的危险包括母体物质暴露、毒物暴露
怀孕和早期生活、母亲健康状况、父母精神病、虐待、结构性
种族主义和过度的压力。为了阐明各种环境危害是如何影响儿童发展的,
当务之急是建立一个关于生命最初10年的发展轨迹的标准模板
基于足够大且人口结构多样化的美国人口样本。要做到这一点,
领导和管理下的健康大脑和儿童发展国家联盟研究(HBCD)
HBCD国家联盟行政核心(HCAC)将部署一个协调、优化和
一套创新的神经成像(MRI、EEG)测量方法,并辅之以广泛的行为、
生理、心理工具和生物标本,以了解神经发育轨迹
在美国各地的网站注册的7500名母亲和婴儿的样本。HBCD的首要目标是
创建一个全面、协调、高维的数据集,该数据集将具有典型的
美国儿童的神经发育轨迹,这将评估生物和环境暴露
影响这些轨迹。将特别强调了解出生前和出生后的影响
接触类阿片、大麻、酒精、烟草和/或其他物质。为了实现这些广泛的目标,
HCAC将监督研究设计、共同方案的制定,并监督招募和
保留,以确保登记的妇女样本包括:1)种族、民族和社会经济
代表美国人群的多样化队列;2)使用靶向物质的孕妇
(类阿片、大麻、酒精、烟草);和3)在人口统计和行为上相似的没有
在怀孕期间使用物质以进行有效的因果推断。HCAC将确保达到研究目标,
监督绩效,提供培训,制定和执行决策和道德政策,管理
所有研究沟通,并监督考虑研究修改的过程。与
HBCD国家联盟数据协调中心(HDCC),HCAC将确保大约每年
研究数据集被发布给更广泛的科学界。HBCD国家联盟的研究将告知
改善全国儿童健康和发展的公共政策。
英文摘要
PROJECT SUMMARY
Neurodevelopmental processes are shaped by dynamic interactions between genes and environments.
Maladaptive experiences early in life can alter developmental trajectories, leading to harmful and enduring
developmental sequelae. Pre- and postnatal hazards include maternal substance exposure, toxicant exposures
in pregnancy and early life, maternal health conditions, parental psychopathology, maltreatment, structural
racism, and excessive stress. To elucidate how various environmental hazards impact child development, it is
imperative that a normative template of developmental trajectories over the first 10 years of life be established
based on a sufficiently large and demographically diverse sample of the US population. To accomplish this, the
Healthy Brain and Child Development National Consortium study (HBCD) under the leadership and management
of the HBCD National Consortium Administrative Core (HCAC) will deploy a harmonized, optimized, and
innovative set of neuroimaging (MRI, EEG) measures complemented by an extensive battery of behavioral,
physiological, and psychological tools, and biospecimens to understand neurodevelopmental trajectories in a
sample of 7,500 mothers and infants enrolled at sites across the US. The overarching goal of the HBCD is to
create a comprehensive, harmonized, and high-dimensional dataset that will characterize typical
neurodevelopmental trajectories in US children and that will assess how biological and environmental exposures
affect those trajectories. A special emphasis will be placed on understanding the impact of pre- and postnatal
exposure to opioids, marijuana, alcohol, tobacco and/or other substances. To address these broad objectives,
the HCAC will oversee study design, development of the common protocol, and monitor recruitment and
retention to ensure that the sample of women enrolled includes: 1) a racially, ethnically, and socioeconomically
diverse cohort that is representative of the US population; 2) pregnant woman with use of targeted substances
(opioids, marijuana, alcohol, tobacco); and 3) demographically and behaviorally similar women without
substance use in pregnancy to enable valid causal inferences. The HCAC will ensure study objectives are met,
monitor performance, provide for training, establish and carry out decision-making and ethical policies, manage
all study communications, and oversee processes for considering study modifications. In collaboration with the
HBCD National Consortium Data Coordinating Center (HDCC), the HCAC will ensure that approximately annual
study datasets are released to the broader scientific community. The HBCD National Consortium study will inform
public policy to improve the health and development of children across the nation.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
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批准号:10682611
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资助金额:$52.6万
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批准号:10661052
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Teratology Society 2019 Annual Meeting - Trainee Travel Awards and Speaker Travel
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资助金额:$1.0万
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依托单位:
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依托单位:
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依托单位:
海外基金