4/6 Planning for the HEALthy Early Development Study

4/6 健康早期发育研究规划

基本信息

批准号：
10166516
负责人：
CHRISTINA CHAMBERS
金额：
$ 22.8万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-30 至 2021-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10166516
关键词：
2019-nCoV Address Administrative Supplement Affect Age Alcohol or Other Drugs use Antibodies Anxiety Area Behavior Behavioral Birth Weight Brain COVID-19 Canada Child Child Development Clinical Research Cognitive Cohort Studies Collection Congenital Abnormality Consent Data Data Analyses Development Emotional Enrollment Ethics Event Exposure to Family Fright Funding Future Goals Grant Growth and Development function Health Health Status Health behavior Human Individual Infant Infection Infrastructure Interview Knowledge Life Link Longitudinal Studies Maternal Health Measures Medical Medical Records Mental Depression Mental Health Newborn Infant Participant Pattern Phase Population Pregnancy Pregnancy Outcome Pregnancy loss Pregnant Women Premature Birth Protocols documentation Recommendation Research Research Personnel Safety Sampling Site Social Impacts Stress Symptoms Test Result Testing Time Virus Visit Vulnerable Populations Woman Women&apos s Health Work care outcomes design disorder risk early childhood economic impact experience follow-up high risk innovative technologies neuroimaging new technology offspring pandemic disease phase 2 study postnatal pregnant prenatal prenatal testing prospective recruit reproductive research study social stressor uptake working group

项目摘要

ABSTRACT The Planning for the HEALthy Early Development Study will contribute to the design and recommended protocol for a future large-scale, multi-site research study to prospectively examine human brain, cognitive, behavioral, social and emotional development of children beginning prenatally through ages 9-10, and to determine the impact of maternal pre- and postnatal substance use on short- and long-term development of children. The Planning Study will link investigators across 6 research sites who have complementary experience and expertise in the areas that are essential to designing the study. Planning activities will be accomplished using a coordinated set of 10 Working Groups who will work collaboratively to design a sampling and recruitment strategy for a future large-scale study, to identify and recommend strategies for addressing the challenges to ethical recruitment and retention of vulnerable populations, and to develop and test a common protocol for neuroimaging, infant and child assessments, exposure assessment, biospecimen collection, and integration of novel technologies. By the end of the Planning Phase, the 6 Consortium sites will have produced and tested a recommended protocol for the future multi-site study, and will have established feasibility of carrying out the study protocol at each of the 6 linked sites.

抽象的健康的早期发展研究的计划将有助于设计和推荐的协议，用于未来的大规模多站点研究，以前瞻性检查开始的儿童的人脑，认知，行为，社会和情感发展产前至9-10岁，并确定产后和产后的影响儿童短期和长期发育的物质使用。计划研究将链接在6个研究网站的研究人员，他们具有互补的经验和专业知识对于设计研究至关重要的领域。计划活动将使用协调组的10个工作组，他们将合作设计抽样和未来大规模研究的招聘策略，以识别并推荐策略解决弱势群体的道德招聘和保留挑战，并开发和测试神经影像，婴儿和儿童评估，暴露的共同方案新技术的评估，生物测量收集和整合。到结束计划阶段，6个财团站点将生成并测试了推荐的协议对于未来的多站点研究，并将确定执行研究方案的可行性在6个链接站点中的每个。

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Realizing Present and Future Promise of DIY Biology and Medicine through a Trust Architecture.

通过信任架构实现 DIY 生物学和医学的当前和未来承诺。

DOI：
10.1002/hast.1194
发表时间：
2020-11
期刊：
The Hastings Center report
影响因子：
0
作者：
Rasmussen LM;Guerrini CJ;Kuiken T;Nebeker C;Pearlman A;Ware SB;Wexler A;Zettler PJ
通讯作者：
Zettler PJ

A socioecological framework for engaging substance-using pregnant persons in longitudinal research: Multi-stakeholder perspectives.

DOI：
10.1016/j.ntt.2021.106997
发表时间：
2021-09
期刊：
Neurotoxicology and teratology
影响因子：
2.9
作者：
Goldstein E;Nervik K;Hagen S;Hilliard F;Turnquist A;Bakhireva LN;McDonald R;Ossorio PN;Lo J;Zgierska AE
通讯作者：
Zgierska AE

Fifty Years of Research on Prenatal Substances: Lessons Learned for the Opioid Epidemic.