4/6 Planning for the HEALthy Early Development Study

4/6 健康早期发育研究规划

• 批准号: 10166516
• 负责人: CHRISTINA CHAMBERS
• 金额: $ 22.8万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2021-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10166516
• 关键词: 2019-nCoV; Address; Administrative Supplement; Affect; Age; Alcohol or Other Drugs use; Antibodies; Anxiety; Area; Behavior; Behavioral; Birth Weight; Brain; COVID-19; Canada; Child; Child Development; Clinical Research; Cognitive; Cohort Studies; Collection; Congenital Abnormality; Consent; Data; Data Analyses; Development; Emotional; Enrollment; Ethics; Event; Exposure to; Family; Fright; Funding; Future; Goals; Grant; Growth and Development function; Health; Health Status; Health behavior; Human; Individual; Infant; Infection; Infrastructure; Interview; Knowledge; Life; Link; Longitudinal Studies; Maternal Health; Measures; Medical; Medical Records; Mental Depression; Mental Health; Newborn Infant; Participant; Pattern; Phase; Population; Pregnancy; Pregnancy Outcome; Pregnancy loss; Pregnant Women; Premature Birth; Protocols documentation; Recommendation; Research; Research Personnel; Safety; Sampling; Site; Social Impacts; Stress; Symptoms; Test Result; Testing; Time; Virus; Visit; Vulnerable Populations; Woman; Women' s Health; Work; care outcomes; design; disorder risk; early childhood; economic impact; experience; follow-up; high risk; innovative technologies; neuroimaging; new technology; offspring; pandemic disease; phase 2 study; postnatal; pregnant; prenatal; prenatal testing; prospective; recruit; reproductive; research study; social; stressor; uptake; working group

ABSTRACT The Planning for the HEALthy Early Development Study will contribute to the design and recommended protocol for a future large-scale, multi-site research study to prospectively examine human brain, cognitive, behavioral, social and emotional development of children beginning prenatally through ages 9-10, and to determine the impact of maternal pre- and postnatal substance use on short- and long-term development of children. The Planning Study will link investigators across 6 research sites who have complementary experience and expertise in the areas that are essential to designing the study. Planning activities will be accomplished using a coordinated set of 10 Working Groups who will work collaboratively to design a sampling and recruitment strategy for a future large-scale study, to identify and recommend strategies for addressing the challenges to ethical recruitment and retention of vulnerable populations, and to develop and test a common protocol for neuroimaging, infant and child assessments, exposure assessment, biospecimen collection, and integration of novel technologies. By the end of the Planning Phase, the 6 Consortium sites will have produced and tested a recommended protocol for the future multi-site study, and will have established feasibility of carrying out the study protocol at each of the 6 linked sites.

摘要 健康早期发展规划研究将有助于设计和 推荐的未来大规模多地点研究研究的推荐方案，以进行前瞻性检查 儿童大脑、认知、行为、社交和情绪发育开始 从产前到9-10岁，并确定母亲产前和产后的影响 物质使用对儿童短期和长期发展的影响。规划研究将链接 6个研究站点的调查人员，他们在以下领域具有互补的经验和专业知识 对设计这项研究至关重要的领域。计划活动将使用 由10个工作组组成的协调小组，他们将协同工作，设计一份抽样和 招聘战略，为未来的大规模研究，以确定和建议战略 应对在道德上招募和留住弱势人口方面的挑战，并 制定和测试神经成像、婴幼儿评估、暴露的通用方案 评估、生物样品收集和新技术的整合。到年底的时候 规划阶段，6个联合体站点将产生并测试推荐的协议 为今后的多点研究，并将建立实施研究议定书的可行性 在6个链接站点中的每一个。

项目成果

Realizing Present and Future Promise of DIY Biology and Medicine through a Trust Architecture.

通过信任架构实现 DIY 生物学和医学的当前和未来承诺。

• DOI: 10.1002/hast.1194
• 发表时间: 2020-11
• 期刊: The Hastings Center report
• 作者: Rasmussen LM;Guerrini CJ;Kuiken T;Nebeker C;Pearlman A;Ware SB;Wexler A;Zettler PJ
• 通讯作者: Zettler PJ

A socioecological framework for engaging substance-using pregnant persons in longitudinal research: Multi-stakeholder perspectives.

• DOI: 10.1016/j.ntt.2021.106997
• 发表时间: 2021-09
• 期刊: Neurotoxicology and teratology
• 影响因子: 2.9
• 作者: Goldstein E;Nervik K;Hagen S;Hilliard F;Turnquist A;Bakhireva LN;McDonald R;Ossorio PN;Lo J;Zgierska AE
• 通讯作者: Zgierska AE

Fifty Years of Research on Prenatal Substances: Lessons Learned for the Opioid Epidemic.

• DOI: 10.1007/s42844-020-00021-7
• 发表时间: 2020-12
• 期刊: Adversity and resilience science
• 作者: Singer LT;Chambers C;Coles C;Kable J
• 通讯作者: Kable J