Social Stress, Adiposity, and Breast Cancer

项目摘要 乳腺癌一直是美国女性癌症的主要形式（美国）。1/8 在一生中接受诊断的女性。身体成分，特别是内脏脂肪组织（VAT）， 绝经后妇女乳腺癌的显著危险因素和预后指标。了解较少 皮下脂肪组织（SAT）在该人群乳腺癌中的作用。增值税的累积 绝经后的女性会导致炎症、代谢和免疫功能障碍的病理生理学， 通过血液生物标志物，这与癌症的发生有关。社会压力在发展中的作用 VAT在心脏代谢文献中已得到充分证实。然而，关于这两个问题的交叉点的文献很少。 社会压力身体成分和乳腺癌该多样性补充的具体目标是 以解决乳腺癌和身体组成文献中的这一关键空白。这些目标将：1.检查 社会压力、肥胖类型（VAT vs. SAT）与乳腺癌发病率和死亡率的关系; 2. 研究血液生物标志物与社会应激的关系，以探索癌症的促癌机制。 绝经后妇女的压力; 3.提供培训及专业发展机会。 瓦伦西亚，一个代表性不足的少数民族早期调查员。通过参与拟议的研究 瓦伦西亚博士将通过培训活动获得身体成分、癌症促进 病理生理学途径和社会压力，以帮助她实现她的最终职业目标，继续 进行有影响力的癌症研究。

Project Summary Breast cancer persists as being the leading form of cancer among women in the United States (U.S.) with 1 in 8 women receiving the diagnosis in their lifetime. Body composition, notably visceral adipose tissue (VAT), is both a salient risk factor and prognostic indicator for breast cancer in post-menopausal women. Less is known about the role of subcutaneous adipose tissue (SAT) in breast cancer in this population. Accumulation of VAT coupled with menopause drives a pathophysiology of inflammatory, metabolic, and immunological dysfunction, measured by blood biomarkers, which are associated with cancer genesis. The role of social stress in the development of VAT is well established in the cardiometabolic literature. Yet, there is a paucity of literature on the intersection of social stress, body composition, and breast cancer. The specific aims of this Diversity Supplement are designed to address this critical gap in the breast cancer and body composition literature. These aims will: 1. Examine the relationship of social stress, adiposity types (VAT vs. SAT), and breast cancer incidence and mortality; 2. Examine the relationship of blood biomarkers and social stress to explore cancer promoting mechanisms of stress in post-menopausal women; 3. Provide training and professional development opportunities to Dr. Valencia, an underrepresented minority early-stage investigator. Through participation in the proposed research and training activities, Dr. Valencia will gain fundamental expertise in body composition, cancer promoting pathophysiological pathways, and social stress to help her achieve her ultimate career goals to continue to perform impactful cancer research.