Supplement to Support Research Training in HDAC11 and Cancer
Supplement to Support Research Training in HDAC11 and Cancer
批准号:
10380397
负责人:
Rong Li
金额:
$7.29万
依托单位国家:
美国
项目类别:
财政年份:
2020
资助国家:
美国
项目状态:
未结题
起止时间:
2020-06-01 至 2025-05-31
关键词:
AcylationAlternative SplicingCancer ModelCell LineChromatinDeacetylaseEpigenetic ProcessExcisionExhibitsGene Expression RegulationGenesGrantHDAC11 geneHDAC4 geneHistone DeacetylaseHistonesImmuneInfiltrationInterferonsKnowledgeLymphomaLysineMalignant NeoplasmsMessenger RNAModelingMusNuclearOncogenesParentsProteinsRNA SplicingRegulationResearch SupportResearch TrainingSignal TransductionTestingTumor ImmunityWorkamidasecancer cellcancer therapycell motilitychromatin modificationinhibitor/antagonistparent grantresponsetherapeutic target
中文摘要
项目摘要
组蛋白去乙酰化酶(HDACs)最初被发现是与遗传学相关的关键表观遗传调节因子。
广泛的癌症中。HDAC与其同名的脱乙酰酶活性最相关;它们
催化从赖氨酸残基上除去乙酰基,这通常使染色质缩合,
减少某些基因的表达。然而,越来越多的证据表明,许多HDAC表现出其他
酶功能如脱脂酰化酶活性。此外,HDAC已经被示出与
组蛋白以外的蛋白质; HDAC 11以前被证明与RNA剪接功能相互作用
机械.因此,HDAC的酶促机制和靶蛋白尚未完全了解。
在补充我们的父母R 01赠款旨在研究HDAC 11在淋巴瘤,我们努力
研究RNA剪接中HDAC 11去酰化。脱乙酰化可以指导蛋白质的定位,
HDAC 11作为胞质脱乙酰酶比作为核脱乙酰酶更有效地发挥功能。
因此,我们的目标是鉴定HDAC 11在癌细胞中的近似蛋白,确定HDAC 11的功能,
去乙酰化,并鉴定响应HDAC 11破坏的可变剪接mRNA。拟议
这项工作将促进对HDAC 11在癌症基因调控中的理解,有助于增加对
HDAC功能的多样性,并可能为HDAC依赖性癌症治疗开辟新的途径。
英文摘要
Project Summary
The histone deacetylaces (HDACs) are originally discovered as critical epigenetic regulators implicated
in a wide range of cancers. HDACs are most associated with their namesake deacetylase activity; they
catalyze the removal of acetyl groups from lysine residues, which typically condenses chromatin and
decreases expression of certain genes. However, there is increasing evidence that many HDACs exhibit other
enzymatic functions such as defatty-acylase activity. Additionally, HDACs have been illustrated to interact with
proteins other than histones; HDAC11 was previously illustrated to functionally interact with RNA splicing
machinery. Thus, the enzymatic mechanism(s) and target proteins of HDACs are not fully understood.
In supplement to our Parent R01 grant aimed at studying HDAC11 in lymphoma, we strive to
investigate HDAC11 defatty-acylation in RNA splicing. Defatty-acylation can direct the localization of proteins,
and HDAC11 functions more efficiently as a cytosolic defatty-acylase than as a nuclear deacetylase.
Therefore, our aim is to identify HDAC11 proximate proteins in cancer cells, pinpoint the function of HDAC11
defatty-acylation, and identify alternatively spliced mRNAs in response to HDAC11 disruption. The proposed
work will advance understanding of HDAC11 in cancer gene regulation, contribute to growing knowledge of
diverse HDAC functions, and potentially open new avenues for HDAC dependent cancer therapies.
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会议论文
Regulation of anti-tumor immunity by HDAC11
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批准号:10436938
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项目类别:
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资助金额:$56.97万
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财政年份:2020
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负责人:Rong Li
-
依托单位:
Regulation of anti-tumor immunity by HDAC11
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批准号:10524141
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项目类别:
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资助金额:$8.44万
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财政年份:2020
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负责人:Rong Li
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依托单位:
Regulation of anti-tumor immunity by HDAC11
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批准号:10640210
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项目类别:
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资助金额:$56.14万
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财政年份:2020
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负责人:Rong Li
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依托单位:
Boosting Antitumor Immunity by Blocking Both Tumor and Adipose DDR1
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批准号:9980667
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项目类别:
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资助金额:$47.69万
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财政年份:2020
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负责人:Rong Li
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依托单位:
Regulation of anti-tumor immunity by HDAC11
-
批准号:10524142
-
项目类别:
-
资助金额:$8.44万
-
财政年份:2020
-
负责人:Rong Li
-
依托单位:
Regulation of anti-tumor immunity by HDAC11
-
批准号:10737815
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项目类别:
-
资助金额:$8.44万
-
财政年份:2020
-
负责人:Rong Li
-
依托单位:
Boosting Antitumor Immunity by Blocking Both Tumor and Adipose DDR1
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批准号:10395597
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项目类别:
-
资助金额:$45.3万
-
财政年份:2020
-
负责人:Rong Li
-
依托单位:
Regulation of anti-tumor immunity by HDAC11
-
批准号:10737814
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项目类别:
-
资助金额:$8.44万
-
财政年份:2020
-
负责人:Rong Li
-
依托单位:
Regulation of anti-tumor immunity by HDAC11
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批准号:10174876
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项目类别:
-
资助金额:$58.81万
-
财政年份:2020
-
负责人:Rong Li
-
依托单位:
Boosting Antitumor Immunity by Blocking Both Tumor and Adipose DDR1
-
批准号:10159224
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项目类别:
-
资助金额:$46.2万
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财政年份:2020
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负责人:Rong Li
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依托单位:
Diversity Supplement Support for a Graduate Student Training in the Studies of HDAC11
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批准号:10380445
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项目类别:
-
资助金额:$8.18万
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财政年份:2020
-
负责人:Rong Li
-
依托单位:
Boosting Antitumor Immunity by Blocking Both Tumor and Adipose DDR1
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批准号:10625964
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项目类别:
-
资助金额:$45.3万
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财政年份:2020
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负责人:Rong Li
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依托单位:
Crosstalk between BRCA1 and Transcription in Breast Cancer
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批准号:9833573
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项目类别:
-
资助金额:$11.84万
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财政年份:2017
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负责人:Rong Li
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依托单位:
Crosstalk between BRCA1 and Transcription in Breast Cancer
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批准号:9517814
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项目类别:
-
资助金额:$41.74万
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财政年份:2017
-
负责人:Rong Li
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依托单位:
Crosstalk between BRCA1 and Transcription in Breast Cancer
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批准号:10438697
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项目类别:
-
资助金额:$42.17万
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财政年份:2017
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负责人:Rong Li
-
依托单位:
Crosstalk between BRCA1 and Transcription in Breast Cancer
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批准号:9390274
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项目类别:
-
资助金额:$29.31万
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财政年份:2017
-
负责人:Rong Li
-
依托单位:
Crosstalk between BRCA1 and Transcription in Breast Cancer
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批准号:10226863
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项目类别:
-
资助金额:$43.04万
-
财政年份:2017
-
负责人:Rong Li
-
依托单位:
Crosstalk between BRCA1 and Transcription in Breast Cancer
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批准号:9979798
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项目类别:
-
资助金额:$43.04万
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财政年份:2017
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负责人:Rong Li
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依托单位:
Re-sensitizing ER-Alpha Mutant Breast Cancer Cells to Hormonal Therapy
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批准号:9302315
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项目类别:
-
资助金额:$16.58万
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财政年份:2016
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负责人:Rong Li
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依托单位:
Re-sensitizing ER-Alpha Mutant Breast Cancer Cells to Hormonal Therapy
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批准号:9178147
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项目类别:
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资助金额:$19.9万
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财政年份:2016
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负责人:Rong Li
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依托单位:
海外基金