Organization and architecture of a Center for cellular resolution analysis of Alzheimer's disease

摘要(管理核心) 该中心的建议是“一个细胞类型水平转录、表观基因组和空间查询的平台”。 阿尔茨海默病“提案旨在将AD病理方面的专业知识与新的单细胞专业知识相结合 分子技术产生新的高分辨率细胞和分子的早期理解 阿尔茨海默病发病机制。该中心由三个研究项目组成，重点是神经病理学， 转录学和表观基因组学，以及空间转录学；数据核心和管理核心 七个PI和三个协作站点。实现该中心的潜力需要强有力的行政管理 领导力，以整合和协同合作的研究人员在大学的努力 华盛顿，凯撒/集团健康和艾伦脑科学研究所。 行政核心将提供中心的结构、领导和业务管理 为实现全面的中心目标，以了解早期的细胞和分子基础 阿尔茨海默病发病机制。这将包括项目管理、战略规划、进度报告、财务 管理以及对协作和通信的支持。管理核心将创建一个 基础设施，促进中心成员之间的沟通和合作，并获得 通过形成外部科学咨询，来自外部AD研究界的投入 委员会审议阶段。该中心将成立一个指导委员会和项目团队，以监督协作、 标准化、及时的数据生成、数据分析和公共数据共享流程。项目管理 最佳实践，如里程碑、进度报告和跟踪、协作软件程序以及 将对中心应用责任矩阵，以确保实现业绩目标和 里程碑、优化的通信以及资源利用和优先顺序。此外，核心将促进 跨项目和机构的联合数据分析工作，包括联合分析工作组和 黑客松。此外，行政核心将支持执行标准作业程序 以及数据生成、数据处理和分析的质量控制标准。要产生高质量的数据 阿尔茨海默病的高分辨率神经病理学和组学分析资源，严谨 标准化和质量控制做法将为所有成员所采用。最后，行政核心意志 执行和维护所有成员的财务和分包商管理流程，管理出版物 以及作者身份决定和冲突解决。随着整个基础设施的实施，我们 预计该项目及其产生的资源将对获得 对阿尔茨海默病的病理和进展有深入的分子和细胞理解。

ABSTRACT (ADMIN CORE) The Center proposal “A platform for cell type-level transcriptomic, epigenomic and spatial interrogation of Alzheimer’s disease” proposal aims to combine expertise in AD pathology with expertise in new single cell molecular technologies to generate a new high resolution cellular and molecular understanding of the early pathogenesis of AD. The Center consists of three Research Projects, focusing on neuropathology, transcriptomics and epigenomics, and spatial transcriptomics; a Data Core, and an Administrative Core with seven PIs and three collaborative sites. Realizing the potential of this Center requires strong administrative leadership to integrate and synergize efforts across the collaborating researchers at the University of Washington, Kaiser/Group Health and the Allen Institute for Brain Science. The Administrative Core will provide the structure, leadership and operational management of the Center towards achievement of the overall Center goals to understand the cellular and molecular basis of the early pathogenesis of AD. This will include project management, strategic planning, progress reporting, fiscal management, and support for collaboration and communication. The Administrative Core will create an infrastructure that fosters communication and collaboration among the Center members, as well as garnering input from the external AD research community through the formation of an External Scientific Advisory committee. The Center will form a Steering Committee and Project Teams to oversee the collaborative, standardized, and on-time data generation, data analysis, and public data sharing process. Project management best practices, such as milestones, progress reporting and tracking, collaborative software programs, and a responsibility matrix will be applied to the Center to ensure achievement of performance objectives and milestones, optimized communication, and resource utilization and prioritization. In addition, the Core will foster joint data analysis efforts across projects and Institutions, including joint Analysis Working Groups and hackathons. Further, the Administrative Core will support the implementation of standard operating procedures and quality control standards for data generation, data processing, and analysis. To produce a high-quality data resource for high resolution neuropathological and omics analysis of Alzheimer’s disease, rigorous standardization and quality control practices will be adopted by all members. Finally, the Administrative Core will implement and maintain fiscal and subcontractor management processes for all members, manage publication and authorship decisions and conflict resolution. With the implementation of this entire infrastructure, we anticipate that this project and the resources it produces will have a broad and meaningful impact on gaining a deep molecular and cellular understanding of Alzheimer’s disease pathology and progression.