Organization and architecture of a Center for cellular resolution analysis of Alzheimer's disease

摘要（管理核心） 该中心的建议“一个平台，细胞类型水平的转录组，表观基因组和空间询问的 阿尔茨海默氏病”的建议旨在将联合收割机在AD病理学方面的专业知识与新的单细胞 分子技术，以产生一个新的高分辨率的细胞和分子的理解， AD的发病机制该中心由三个研究项目组成，重点是神经病理学， 转录组学和表观基因组学以及空间转录组学;数据核心和管理核心， 七个PI和三个协作站点。实现该中心的潜力需要强有力的行政管理 领导力，以整合和协同努力，在大学的合作研究人员 华盛顿，凯泽/集团健康和艾伦脑科学研究所。 行政核心将提供中心的结构、领导和业务管理 为了实现中心的总体目标，了解早期癌症的细胞和分子基础， AD的发病机制这将包括项目管理、战略规划、进度报告、财务 管理，并支持协作和沟通。行政核心将创建一个 基础设施，促进中心成员之间的沟通和协作，以及获得 通过成立外部科学咨询机构，从外部AD研究界获得投入 以马克思该中心将成立一个指导委员会和项目小组， 标准化、及时的数据生成、数据分析和公共数据共享流程。项目管理 最佳实践，如里程碑、进度报告和跟踪、协作软件程序，以及 责任矩阵将应用于中心，以确保实现绩效目标， 里程碑、优化沟通、资源利用和优先级。此外，核心将培育 跨项目和机构的联合数据分析工作，包括联合分析工作组， 黑客马拉松此外，行政核心将支持执行标准作业程序 以及数据生成、数据处理和分析的质量控制标准。为了生成高质量的数据， 阿尔茨海默病的高分辨率神经病理学和组学分析资源，严格 所有成员将采用标准化和质量控制做法。最后，行政核心将 实施和维护所有成员的财务和分包商管理流程，管理出版物 以及作者决定和冲突解决。随着整个基础设施的实施，我们 预计这个项目及其产生的资源将对获得一个广泛而有意义的影响， 深入了解阿尔茨海默病的病理和进展的分子和细胞。

ABSTRACT (ADMIN CORE) The Center proposal “A platform for cell type-level transcriptomic, epigenomic and spatial interrogation of Alzheimer’s disease” proposal aims to combine expertise in AD pathology with expertise in new single cell molecular technologies to generate a new high resolution cellular and molecular understanding of the early pathogenesis of AD. The Center consists of three Research Projects, focusing on neuropathology, transcriptomics and epigenomics, and spatial transcriptomics; a Data Core, and an Administrative Core with seven PIs and three collaborative sites. Realizing the potential of this Center requires strong administrative leadership to integrate and synergize efforts across the collaborating researchers at the University of Washington, Kaiser/Group Health and the Allen Institute for Brain Science. The Administrative Core will provide the structure, leadership and operational management of the Center towards achievement of the overall Center goals to understand the cellular and molecular basis of the early pathogenesis of AD. This will include project management, strategic planning, progress reporting, fiscal management, and support for collaboration and communication. The Administrative Core will create an infrastructure that fosters communication and collaboration among the Center members, as well as garnering input from the external AD research community through the formation of an External Scientific Advisory committee. The Center will form a Steering Committee and Project Teams to oversee the collaborative, standardized, and on-time data generation, data analysis, and public data sharing process. Project management best practices, such as milestones, progress reporting and tracking, collaborative software programs, and a responsibility matrix will be applied to the Center to ensure achievement of performance objectives and milestones, optimized communication, and resource utilization and prioritization. In addition, the Core will foster joint data analysis efforts across projects and Institutions, including joint Analysis Working Groups and hackathons. Further, the Administrative Core will support the implementation of standard operating procedures and quality control standards for data generation, data processing, and analysis. To produce a high-quality data resource for high resolution neuropathological and omics analysis of Alzheimer’s disease, rigorous standardization and quality control practices will be adopted by all members. Finally, the Administrative Core will implement and maintain fiscal and subcontractor management processes for all members, manage publication and authorship decisions and conflict resolution. With the implementation of this entire infrastructure, we anticipate that this project and the resources it produces will have a broad and meaningful impact on gaining a deep molecular and cellular understanding of Alzheimer’s disease pathology and progression.