CREATING A DEVELOPMENTAL GENE EXPRESSION ATLAS FOR RHESUS MACAQUE BRAIN

为恒河猴大脑创建发育基因表达图谱

• 批准号: 8357342
• 负责人: Ed Lein
• 金额: $ 10.1万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357342
• 关键词: Adult; Atlases; Biological Models; Brain; California; Communities; Development; Developmental Gene; Developmental Process; Funding; Gene Expression; Genes; Goals; Grant; Human; Macaca mulatta; National Center for Research Resources; Pattern; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Source; United States National Institutes of Health; cost; genome sequencing; nervous system development; nervous system disorder; nonhuman primate; spatiotemporal

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The goal of the current proposal is to generate a neurodevelopmental atlas of gene expression in the rhesus macaque brain, creating a unique public access community resource detailing precise cellular level spatiotemporal expression patterns of developmentally regulated and functionally important genes. Understanding of human nervous system development is of critical importance for understanding normal developmental processes and human neurological disorders with developmental components. Non-human primates provide valuable and experimentally tractable model systems for studying brain development with direct relevance to humans. While nonhuman primates have been a major focus for genome sequencing projects, very little focus has been put on studying detailed spatiotemporal patterns of gene expression in the developing or adult brain. A developmental gene expression atlas for the rhesus macaque brain will be an extremely valuable resource for understanding developmental processes in primates.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 当前提案的目标是生成恒河猴大脑中基因表达的神经发育图谱，创建一个独特的公共访问社区资源，详细描述发育调节和功能重要基因的精确细胞水平时空表达模式。了解人类神经系统发育对于了解正常发育过程和具有发育成分的人类神经系统疾病至关重要。非人类灵长类动物为研究与人类直接相关的大脑发育提供了有价值的和实验上易于处理的模型系统。虽然非人灵长类动物一直是基因组测序项目的主要焦点，但很少有人关注发育中或成年大脑中基因表达的详细时空模式。恒河猴大脑发育基因表达图谱将是了解灵长类动物发育过程的一个非常有价值的资源。