Human 3D Neuro-Vascular Interaction and Meningeal Lymphatic Models with Application to Alzheimer’s Disease

人体 3D 神经血管相互作用和脑膜淋巴模型在阿尔茨海默病中的应用

基本信息

  • 批准号:
    10396570
  • 负责人:
  • 金额:
    $ 51.63万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-05-01 至 2026-04-30
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY As the elderly population increases, the number of people with Alzheimer's disease (AD) is rising rapidly. There is, therefore, a growing interest in the development of in vitro human disease models to better understand and study the physiological and pathological mechanisms associated with AD. Emerging evidence has implicated an early breakdown of the BBB in AD patients, even before the cognitive decline and brain pathology. In addition, meningeal lymphatics are responsible for clearance of Aβ peptides from the brain parenchyma, and disruption of meningeal lymphatics in AD transgenic mice accelerates Aβ deposition in the meninges, aggravates parenchymal Aβ accumulation, and induces cognitive impairment. Yet, our understanding of the role of fluid transport across the BBB, through the brain parenchyma, and exiting via the lymphatic system is poorly understood. Therefore, the development of physiologically realistic human neural cell culture models of AD with a neurovascular unit and meningeal lymphatic vessels is urgently needed to dissect molecular mechanisms underlying the pathogenic cascade of AD and accelerate the discovery of new AD drugs. Building on our extensive set of preliminary and related studies, we propose to develop a three-dimensional (3D) in vitro model by integrating BBB, meningeal lymphatics, and stem-cell-derived AD cell culture to closely mimic the AD brain environment. With this model, we aim to identify AD-specific mechanisms underlying pathophysiological changes in the BBB, meningeal lymphatics, and Aβ clearance. Our 3D AD model will be useful for not only studying the mechanisms of AD progression but also for drug discovery in a human brain-like environment.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

SE HOON CHOI其他文献

SE HOON CHOI的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('SE HOON CHOI', 18)}}的其他基金

Exploring irisin as a novel target for Alzheimers Disease
探索鸢尾素作为阿尔茨海默病的新靶点
  • 批准号:
    10670486
  • 财政年份:
    2022
  • 资助金额:
    $ 51.63万
  • 项目类别:
Human 3D Neuro-Vascular Interaction and Meningeal Lymphatic Models with Application to Alzheimer’s Disease
人体 3D 神经血管相互作用和脑膜淋巴模型在阿尔茨海默病中的应用
  • 批准号:
    10179538
  • 财政年份:
    2021
  • 资助金额:
    $ 51.63万
  • 项目类别:
Human 3D Neuro-Vascular Interaction and Meningeal Lymphatic Models with Application to Alzheimer’s Disease
人体 3D 神经血管相互作用和脑膜淋巴模型在阿尔茨海默病中的应用
  • 批准号:
    10615081
  • 财政年份:
    2021
  • 资助金额:
    $ 51.63万
  • 项目类别:
Exploring irisin as a novel target for Alzheimer's Disease
探索鸢尾素作为阿尔茨海默病的新靶点
  • 批准号:
    9919511
  • 财政年份:
    2019
  • 资助金额:
    $ 51.63万
  • 项目类别:

相似海外基金

ENVIRONMENTAL ENRICHMENT EFFECTS IN AD TRANSGENIC MICE
AD 转基因小鼠的环境富集效应
  • 批准号:
    6932636
  • 财政年份:
    2005
  • 资助金额:
    $ 51.63万
  • 项目类别:
ENVIRONMENTAL ENRICHMENT EFFECTS IN AD TRANSGENIC MICE
AD 转基因小鼠的环境富集效应
  • 批准号:
    7309938
  • 财政年份:
  • 资助金额:
    $ 51.63万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了