Clinical Core D

项目摘要-临床和生物统计学核心D 得克萨斯州艾滋病研究发展中心(D-CFAR)设在贝勒医学院 (贝勒)和德克萨斯大学休斯顿健康科学中心(UTHealth)和德克萨斯生物医学 圣安东尼奥的研究机构(TxBimed)。一个战略规划过程证明了临床和 在国内机构的现有研究人员和早期研究人员中提供生物统计学研究支持。 因此，德克萨斯州D-CFAR将建立一个临床和生物统计核心(CBC，核心D)，以对 艾滋病毒研究人员和生物统计学家的资源和专业知识，以促进高影响的临床、翻译 以及旨在结束艾滋病毒和优化德克萨斯州艾滋病毒健康的基础科学研究。核心领导力 团队在研究设计、临床研究和研究实施以及数据方面拥有丰富的经验 管理和分析。它还与国家生物库和储存库建立了良好的联系，因此 定位于接触和支持各种不同的调查人员。德克萨斯州D-CFAR调查人员及其附属机构 用户，无论是初级的还是艾滋病毒研究或参与机构的新手，都可能缺乏如何 设计、启动和实施研究；如何获取或获取临床样本或数据；和/或如何设计 并执行适当和可靠的数据管理和分析计划。CBC的目标是填补这一空白。至 为此，Core D将为初级调查人员提供项目开发和实施服务 或艾滋病毒研究或D-CFAR机构的新成员；提供获取人体组织和血液样本的途径，促进 临床、转化和基础科学研究；并提供数据分析、数据管理和 为艾滋病毒研究或D-CFAR初级或新手的研究人员提供生物统计学咨询服务 机构。D-CFAR CBC将通过指导和招募来激励，并通过项目促进 实施高影响力的研究，满足当前和预期的临床、转换和基础研究 当地研究人员、美国国立卫生研究院和我们当地社区的科学研究和教育需求 携带艾滋病毒并有感染艾滋病毒的风险。核心领导层与D-CFAR领导层合作，确定了一项 全面的行动计划、一套活动、政策和程序以及评估标准，以确保成功。 通过实现我们的目标，我们将朝着结束艾滋病毒和优化艾滋病毒健康的目标前进 德克萨斯州，并能够在5年内过渡到全额CFAR资金。

PROJECT SUMMARY – CLINICAL AND BIOSTATISTICS CORE D The Texas Developmental Center for AIDS Research (D-CFAR) is based at Baylor College of Medicine (Baylor) and University of Texas Health Science Center at Houston (UTHealth) and the Texas Biomedical Research Institute (TxBiomed) in San Antonio. A strategic planning process demonstrated need for clinical and biostatitistical research support among both established and early stage investigators at the home institutions. The Texas D-CFAR will therefore establish a Clinical and Biostatistics Core (CBC, Core D) to capiltalize on the resources and expertise of HIV investigators and biostatisticians to facilitate high-impact clinical, translational and basic science research aimed at Ending HIV and Optimizing HIV Health in Texas. The Core leadership team has extensive experience in study design, clinical research, and research implementation, and data management and analysis. It also is well connected with national biobanks and repositories and is thus positioned to reach and support a diverse array of investigators. Texas D-CFAR investigators and affiliated users, whether junior or new to HIV research or the participating institutions, may lack knowledge of how to design, initiate and implement studies; how to obtain or access clinical samples or data; and/or how to design and execute appropriate and reliable data management and analytic plans. The CBC goal is to fill that gap. To do this, Core D will provide project development and implementation services for investigators who are junior or new to HIV research or D-CFAR institutions; provide access to human tissue and blood samples, facilitating clinical, translational and basic science research; and provide data analysis, data management and consultative biostatistical services to investigators who are junior or new to HIV research or D-CFAR institutions. The D-CFAR CBC will stimulate through mentorship and recruitment and facilitate through project implementation high-impact research, meeting the current and anticipated clinical, translational and basic science research and educational needs of local investigators, the NIH and our local communities of people with and at risk for HIV. The Core leadership, in collaboration with the D-CFAR leadership, has identified a comprehensive action plan, set of activities, policies and procedures and evaluation metrics to ensure success. Through accomplishing our aims, we will move toward our goal of Ending HIV and Optimizing HIV Health in Texas and be able to transition to full CFAR funding in 5 years.