The National Collaborative Study of Early Psychosis and Suicide (NCSEPS)

虽然对这些数据的分析仍在进行中，但已出现了一些令人感兴趣的发现。这些工作中的一部分是在神经精神病学分支完成的，但大部分工作仍在我们的部门继续进行，我们有几个有希望的未来研究途径。当项目转移到我的团队时，我们花了几个月的时间来精简数据库，并为项目创建了一个详尽的代码本，描述了它的起源，它的源数据，它的数据集中的变量，以及访问这些数据的指令。 第一组分析表明，军队中首次住院治疗严重精神疾病的负担很大。 该队列死亡率的其他数据来自国家死亡指数。 2006年，流行病学研究学会对新数据进行了分析。 住院的3组军事人员的全因死亡率大幅增加（危险比从单相抑郁症的1.7增加到精神分裂症的3.5）。 自杀者的死亡风险明显更高（单相抑郁症的HR=2.1;精神分裂症的HR = 8.5）。 这篇论文已提交出版（Herrell等人，正在审查中）。另一篇由Grammer等人撰写的关于“生活事件对精神疾病发展的影响”的论文也在审查中。

Although analyses of these data are ongoing, a number of interesting findings have emerged. Some of this work was completed in the Neuropsychiatry Branch, but much of it has continued in our Section, and we have several promising avenues for future research. When the project was transferred to my group, we invested several months streamlining the database, and creating an exhaustive codebook for the project describing its origins, its source data, the variables in its dataset, and instructions for accessing these data. The first set of analyses demonstrated the substantial burden of first hospitalizations for severe psychiatric illness in the military. Additional data on mortality in this cohort were obtained from the National Death Index. Analyses from the new data were presented at the Society for Epidemiological Research in 2006. All-cause mortality in the 3 groups of military personnel who were hospitalized are substantially increased (hazard ratios from 1.7 for unipolar depression) to 3.5 for schizophrenia). Risk of death was substantially higher for suicides (HR=2.1 for unipolar depression; 8.5 for schizophrenia). This paper has been submitted for publication (Herrell et al, under review). Another paper on "The impact of life events on the development of psychiatric disorders" by Grammer et al, is also under review.