Learning and plasticity in the human brain

人脑的学习和可塑性

• 批准号: 7594615
• 负责人: Christopher Baker
• 金额: $ 122.13万
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7594615
• 关键词: Affect; Amputation; Area; Brain; Brain Part; Brain imaging; Brain region; Complex; Development; Functional Magnetic Resonance Imaging; Goals; Human; Investigation; Lead; Learning; Limb structure; Localized; Macular degeneration; Measures; Modality; Nervous system structure; Peripheral; Process; Research; Sensory; Vision; Visual Cortex; experience; neural circuit; novel; programs; relating to nervous system; visual deprivation; visual process; visual processing; visual stimulus

Our research program is concerned with elucidating the neural changes associated with learning and experience, particularly in the context of vision. In the past year we have focused on identifying neural changes underlying learning of visual stimuli (such as complex novel objects) and on determining how visual processing in the brain is altered following the loss of central vision (caused by macular degeneration). Our functional brain imaging studies on learning have shown that short term learning of visual stimuli is associated with changes in brain activation across large areas of the visual cortex, but that long term learning may be lead to the development of specialized neural circuits in localized brain regions. Our research on visual deprivation has shown that following the loss of central vision, the brain reorganizes so that parts of the brain usually responsible only for central vision are now active for peripheral vision. Building on these findings, investigations are underway to determine how loss of input in other sensory modalities (for example, following the amputation of a limb) affects neural processing in the brain, and to determine the consequences of brain reorganization.

我们的研究项目关注于阐明与学习和经验相关的神经变化，特别是在视觉的背景下。在过去的一年里，我们专注于识别视觉刺激（如复杂的新物体）学习背后的神经变化，以及确定中央视力丧失（由黄斑变性引起）后大脑中的视觉处理是如何改变的。