Multi-level school-based intervention to improve HPV vaccine uptake and completion in South Africa
以学校为基础的多层次干预措施提高南非 HPV 疫苗的接种率和完成率
基本信息
- 批准号:10730916
- 负责人:
- 金额:$ 33.97万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-08-07 至 2026-07-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdministratorAdolescentAgeAnogenital cancerAreaCancer ControlCancer EtiologyCaringChargeChildClinical TrialsCommunicationCommunitiesConsultDecision MakingDoseDropsEducational CurriculumEffectivenessEligibility DeterminationEnrollmentEnsureEpidemicEvaluationExposure toFemaleFocus GroupsGenderGoalsGovernmentGrantHIVHealthHealth behaviorHealthcareHuman Papilloma Virus VaccinationHuman Papilloma Virus VaccineHuman Papilloma Virus-Related Malignant NeoplasmHuman PapillomavirusHuman ResourcesHybridsImmunizationImmunization ProgramsIncomeIndividualInfluentialsInstitutionInterruptionInterventionInterviewLinkMalignant NeoplasmsMalignant neoplasm of cervix uteriMeasuresMedicalMethodsMisinformationNursesOwnershipParentsParticipantPhasePopulation HeterogeneityPreparationPreventionQuestionnairesRandomizedRandomized, Controlled TrialsResearchResearch PersonnelResource-limited settingSamplingSchool-Age PopulationSchoolsSexually Transmitted DiseasesSouth AfricaSouth AfricanStructureStudentsSystemTestingUnited StatesVaccinatedVaccinesVoiceVulnerable PopulationsWomanacceptability and feasibilityboyscancer preventioncivil societycommunity engagementcoronavirus diseasedesigneffectiveness evaluationelementary schoolfeasibility trialfifth gradegirlshealth communicationhealth equityhybrid type 2 trialimprovedlearning materialsmalignant oropharynx neoplasmmortalityprogramsrecruitschool healthsexual debutsocial mediastudy populationteachertrial planninguptakeurban settingvaccination strategyvaccine acceptancevaccine hesitancyworking groupyoung woman
项目摘要
PROJECT SUMMARY
Human Papillomavirus (HPV) is the most common sexually transmitted infection globally, and is causally
linked to cervical, anogenital, and oropharyngeal cancers. HPV-associated cancers have a disproportionate
impact in low-resource settings and nowhere is this evident than in South Africa, which has a uniquely
vulnerable population due to the convergence of the largest HIV epidemic globally, with HPV rates of up to
85% in young women under the age of 25. Cervical cancer is the leading cause of cancer-related mortality
among women in South Africa. In 2014, the South African National Department of Health implemented a
national, school-based HPV immunization program. Despite a promising start, vaccine coverage and dose
completion rates dropped precipitously after 2014, with only 37% of girls receiving their first dose in 2021.
Recent declines have been attributed to COVID-related program interruptions, increased medical mistrust, and
vaccine hesitancy related to misinformation spread on social media. There are additional critical gaps in care –
specifically boys who are ineligible for this program, as well as adolescents outside the public school system.
There is an urgent need to identify effective, replicable, and scalable strategies to optimize HPV vaccine
uptake and completion in school-age children. The overall objective of the proposed R34 is to refine and
evaluate a school-based multi-level communications strategy that addresses intrapersonal, interpersonal, and
institutional factors associated with HPV vaccine uptake and completion amongst fifth graders, as part of a pilot
feasibility trial. The proposed study is led by investigators from the United States and South Africa in
partnership with the Department of Health and elementary schools in an urban setting with high burden of HPV
vaccine preventable cancers in KwaZulu Natal, South African. The project builds upon our team’s expertise in
HPV prevention, vaccine decision making, health communications, participatory design, and community
engagement to pursue the following Specific Aims. (1) To refine components of a school-based multi-level
communication strategy to improve HPV vaccine uptake and completion among girls and boys, and (2)
To evaluate preliminary effects of the communications strategy and key criteria to advance to a full-
scale hybrid type 2 trial. Our systems-focused approach leverages established partnerships with area
schools serving diverse populations who are not always effectively served by traditional healthcare channels.
We will ensure health equity is at the core of our research integrating the voices of individuals living in low-
resource settings to understand and reduce the barriers to HPV vaccine initiation and completion. This
proposal is responsive to NCI’s call for cancer prevention and control clinical trials planning grants (PAR-22-
173) both in its active stakeholder engagement, and its focus on engaging a diverse, scientifically appropriate
study population.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('Lisa Michelle Butler', 18)}}的其他基金
Multi-Sectoral Agricultural Intervention to Improve Nutrition, Health, and Developmental Outcomes of HIV-infected and Affected Children in Western Kenya
多部门农业干预措施改善肯尼亚西部艾滋病毒感染和受影响儿童的营养、健康和发育成果
- 批准号:
9357689 - 财政年份:2016
- 资助金额:
$ 33.97万 - 项目类别:
Agricultural Intervention to Improve Health of HIV-infected and Affected Children
改善艾滋病毒感染和受影响儿童健康的农业干预措施
- 批准号:
8450089 - 财政年份:2012
- 资助金额:
$ 33.97万 - 项目类别:
Comparative effectiveness of pediatric HIV disclosure interventions in Uganda
乌干达儿童艾滋病毒披露干预措施的比较效果
- 批准号:
8706933 - 财政年份:2012
- 资助金额:
$ 33.97万 - 项目类别:
CHAT: mHealth Innovation for HIV-MNCH Community Health Workers in South Africa
聊天:南非 HIV-MNCH 社区卫生工作者的移动医疗创新
- 批准号:
8529620 - 财政年份:2012
- 资助金额:
$ 33.97万 - 项目类别:
Agricultural Intervention to Improve Health of HIV-infected and Affected Children
改善艾滋病毒感染和受影响儿童健康的农业干预措施
- 批准号:
8263268 - 财政年份:2012
- 资助金额:
$ 33.97万 - 项目类别:
Comparative effectiveness of pediatric HIV disclosure interventions in Uganda
乌干达儿童艾滋病毒披露干预措施的比较效果
- 批准号:
8870398 - 财政年份:2012
- 资助金额:
$ 33.97万 - 项目类别:
CHAT: mHealth Innovation for HIV-MNCH Community Health Workers in South Africa
聊天:南非 HIV-MNCH 社区卫生工作者的移动医疗创新
- 批准号:
8706238 - 财政年份:2012
- 资助金额:
$ 33.97万 - 项目类别:
CHAT: mHealth Innovation for HIV-MNCH Community Health Workers in South Africa
聊天:南非 HIV-MNCH 社区卫生工作者的移动医疗创新
- 批准号:
8330030 - 财政年份:2012
- 资助金额:
$ 33.97万 - 项目类别:
Comparative effectiveness of pediatric HIV disclosure interventions in Uganda
乌干达儿童艾滋病毒披露干预措施的比较效果
- 批准号:
8517790 - 财政年份:2012
- 资助金额:
$ 33.97万 - 项目类别:
Comparative effectiveness of pediatric HIV disclosure interventions in Uganda
乌干达儿童艾滋病毒披露干预措施的比较效果
- 批准号:
8390950 - 财政年份:2012
- 资助金额:
$ 33.97万 - 项目类别:
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