PDX Core

PDX核心

• 批准号: 10733312
• 负责人: JENNIFER E KOBLINSKI
• 金额: $ 30.1万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-19 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10733312
• 关键词: Advanced Malignant Neoplasm; Archives; Bioinformatics; Biological Specimen database; Black Populations; Black race; Breast; Cancer Center; Carcinomatosis; Characteristics; Clinical; Collaborations; Collection; Communication; Communities; Data; Data Commons; Development; Diagnosis; Educational workshop; Equity; Genitourinary system; Genomics; Gynecologic; Health Disparities Research; Histologic; Investigation; Latinx; Libraries; Link; Lung; Malignant Neoplasms; Massey Cancer Center at the Virginia Commonwealth University; Minority Groups; Modeling; Molecular; Organoids; Pancreas; Pancreatic Adenocarcinoma; Patients; Peritoneal; Pilot Projects; Population; Preclinical Testing; Primary Neoplasm; Program Research Project Grants; Quality of Care; RNA; Research; Research Project Grants; Research Support; Sampling; Site; Specimen; System; Tissue Expansion; Tissue Harvesting; Tumor Tissue; Underrepresented Minority; Underrepresented Populations; Universities; Virginia; advanced system; cancer subtypes; cancer type; central database; ethnic diversity; ethnic minority population; gastrointestinal; health equity; immunohistochemical markers; improved; malignant breast neoplasm; meetings; multiple omics; operation; patient derived xenograft model; patient population; personalized approach; programs; racial diversity; racial minority population; relational database; repository; safety net; therapeutic development; tumor

PROJECT SUMMARY / ABSTRACT U4HELPP PDX CORE A profound limitation to personalized approaches for therapeutic development in cancer is the lack of relevant patient derived models in all cancer types, especially those from underrepresented minority groups with more aggressive, recalcitrant and/or advanced clinical stages. The overall objectives of United for Health Equity in Living PDX Program (U4HELPP) will be to increase diverse representation and study of racial/ethnic minority populations through development and investigations on more racial/ethnically diverse patient-derived xenograft models (PDX) to advance cancer health disparity research. The U4HELPP PDX Core will serve as a central point for patient-derived viable tumor tissue harvest and expansion to fully support Research Projects 1 & 2 and Pilot Project and Trans-network Activities Core. The U4HELPP PDX Core will also serve as a central database of these specimens with clinical and molecular characteristics, including ancestry, of each cancer subtype, linked to molecular genomics.

项目总结/摘要 U4 HELPP PDX核心 癌症治疗开发的个性化方法的一个深刻限制是缺乏相关的 所有癌症类型的患者衍生模型，特别是那些来自代表性不足的少数群体的模型， 侵袭性的、难治性的和/或晚期的临床阶段。卫生公平联合会的总体目标是： 生活PDX计划（U4 HELPP）将增加种族/少数民族的多元化代表性和研究 通过开发和研究更多人种/种族多样性的患者来源异种移植物 模型（PDX），以推进癌症健康差异研究。U4 HELPP PDX核心将作为中心点 用于患者来源的活肿瘤组织采集和扩增，以充分支持研究项目1和2以及试点项目 项目和跨网络活动核心。U4 HELPP PDX Core还将作为一个中央数据库， 这些标本与每种癌症亚型的临床和分子特征，包括祖先， 到分子基因组学