PDX Core

项目摘要/摘要 U4HELPP PDX核心 癌症治疗发展的个性化方法的一个严重限制是缺乏相关的 所有癌症类型的患者衍生模型，特别是那些来自代表不足的少数群体的模型 侵袭性、顽固性和/或晚期临床。年健康公平联合组织的总体目标 Living PDX计划(U4HELPP)将增加对种族/少数民族的多样化代表和研究 通过对更多种族/民族多样化的患者来源的异种移植的开发和调查 推进癌症健康差异研究的模型(PDX)。U4HELPP PDX核心将作为中心点 用于患者来源的活肿瘤组织的采集和扩增，以完全支持研究项目1和2以及试点 项目和跨网络活动核心。U4HELPP PDX核心还将作为 这些样本具有临床和分子特征，包括祖先，每个癌症亚型，连接 分子基因组学。

PROJECT SUMMARY / ABSTRACT U4HELPP PDX CORE A profound limitation to personalized approaches for therapeutic development in cancer is the lack of relevant patient derived models in all cancer types, especially those from underrepresented minority groups with more aggressive, recalcitrant and/or advanced clinical stages. The overall objectives of United for Health Equity in Living PDX Program (U4HELPP) will be to increase diverse representation and study of racial/ethnic minority populations through development and investigations on more racial/ethnically diverse patient-derived xenograft models (PDX) to advance cancer health disparity research. The U4HELPP PDX Core will serve as a central point for patient-derived viable tumor tissue harvest and expansion to fully support Research Projects 1 & 2 and Pilot Project and Trans-network Activities Core. The U4HELPP PDX Core will also serve as a central database of these specimens with clinical and molecular characteristics, including ancestry, of each cancer subtype, linked to molecular genomics.