MOIR - Administrative Core

摘要-行政核心 P01计划赠款的行政核心，题为“多OMIcs识别和验证 免疫干预引发的机制，旨在减少复制能力的大小 水库“（多组学免疫水库- MOIR）将提供科学，财政和监管监督所有 参与机构和临床研究中心的P01项目组成部分。此P01包含3个 研究项目，管理核心，机器学习和建模核心。的总体目标 行政核心是建立一个有组织的研究环境，促进合作互动 研究者之间，促进创新研究，并满足P01的关键目标。行政 核心将蓬勃发展，以确保科学工作计划的执行符合最高的道德标准， 遵循最严格的严谨性和可重复性原则。行政核心将完成这些任务 通过以下三个具体目标实现目标：1）为整体管理创建基础设施计划 P01活动的协调; 2）提供科学和财政监督， 进度报告，以确保P01符合规定的里程碑和时间表;以及 3)促进项目和核心之间的有效沟通和富有成效的互动。的 行政核心的组织基础设施包括行政核心理事会、 科学指导委员会（SC）和科学咨询委员会（SAB）。常设委员会成员（项目和 核心领导人）将负责科学监督、项目活动评估、伦理、科学 诚信和监管。行政协调会成员包括项目和核心牵头项目执行人， P01和项目经理，将协调高度综合的科学议程，提供财政支持， 监督，管理科学界和非科学界之间的数据存储和数据共享，并建立 集中的网站，以促进内部和外部的P01社区的沟通。以促进 PI，博士后研究员，学生和研究支持人员之间的互动，行政核心将 组织月度和年度会议，讨论科学进展和计划活动。此外该 行政团队将确保正确执行和遵守所有合同协议（MTA和 与P01相关的IRB）。行政协调会和科学委员会将共同努力， 和核心，促进社区参与，协助解决冲突和争端，并实施战略 实现计划目标的方法。

ABSTRACT – ADMINISTRATIVE CORE The Administrative core of the P01 program grant entitled “Multi-OMIcs identification and validation of mechanisms triggered by Immune interventions aimed at reducing the size of the replication competent Reservoir “ (Multiomics Immunity Reservoir- MOIR) will provide scientific, fiscal, and regulatory oversight for all components of the P01 program across the participating institutions and clinical sites. This P01 contains 3 Research Projects, an Administrative Core, and a Machine Learning and Modeling Core. The overall goal of the administrative core is to establish an organized research environment that will foster collaborative interactions between investigators, promote innovative research, and meet the key objectives of the P01. The administrative core will thrive to ensure that scientific work plans are performed according to the highest ethical standards and follow the most stringent principles of rigor and reproducibility. The Administrative core will accomplish these goals through the following three specific aims: 1) Create an infrastructure plan for the overall management and coordination of the P01 activities; 2) Provide scientific and fiscal oversight, and generate annual progress reports to ensure that the P01 is in compliance with the stated milestones and timelines; and 3) Facilitate effective communication and foster productive interactions among Projects and Cores. The organizational infrastructure of the Administration core consists of an Administration Core Council (ACC), a scientific steering committee (SC), and a Scientific Advisory Board (SAB). The members of the SC (project and core leaders) will be responsible for scientific oversight, evaluation of program activities, ethical, scientific integrity and regulatory oversight. The ACC members, which consist of the Project and Core Lead PIs of the P01 and the program manager, will coordinate the highly integrative scientific agenda, provide financial oversight, manage data storage and data sharing among the scientific and lay community and establish a centralized website to facilitate communication both within and outside the P01 community. To facilitate interactions between PIs, postdoctoral fellows, students, and research support staff, the administrative core will organize monthly and annual meetings to discuss scientific progress and program activities. In addition, the administrative team will ensure the proper execution and adherence to all contractual agreements (MTA and IRBs) associated with the P01. Together the ACC and SC will serve to maximize the synergy between projects and cores, promote community engagement, assist in resolving conflicts and disputes, and implement a strategic approach to accomplish the Program goals.