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Emory/Georgia TB Research Advancement Center (TRAC)

埃默里/佐治亚州结核病研究促进中心 (TRAC)

基本信息

批准号：
10429404
负责人：
Rafick Pierre Sekaly
金额：
$ 19.73万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-03-23 至 2027-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10429404
关键词：
ATAC-seq Address Area Basic Science Bioinformatics Biological Assay Biological Markers Cells Cellular Indexing of Transcriptomes and Epitopes by Sequencing Clinical Clinical Sciences Communicable Diseases Communities Complex Computational Biology Computer Models Consult Consultations Core Facility Data Data Analyses Data Set Development Diagnosis Disease Disease Progression Doctor of Philosophy Education Educational workshop Environment Experimental Designs Faculty Flow Cytometry Fostering Functional disorder Funding Genes Genomics Immune Evasion Immunity Immunology Immunology procedure Individual Infrastructure Institution Intake Interdisciplinary Study Investigation Knowledge Laboratories Lead Leadership Measurement Mentorship Metabolic Pathway Methods Modeling Multiomic Data Pathway Analysis Postdoctoral Fellow Prevention Records Research Research Design Research Personnel Research Training Resolution Resource Sharing Resources Services Structure System Systems Biology Technology Tissues Training Translational Research Tuberculosis United States National Institutes of Health World Health Organization computational pipelines cytokine data acquisition data integration education resources epigenomics experimental study graduate student high dimensionality innovation lipidome lipidomics member metabolic phenotype metabolome metabolomics microbiome analysis multidimensional data multiple omics multiscale data next generation novel single cell technology tool transcriptome sequencing transcriptomics uptake

项目摘要

The Bioinformatics and Integrated Systems Biology (Systems Biology) Core will represent an integral component of the Emory/Georgia TRAC. While individual members of the Emory/Georgia TB research community have strong records of collaborative TB research, access to cutting edge methods in systems biology have not been easily accessible. Although the partner institutions of the Emory/Georgia TRAC host a wide variety of Core facilities performing ‘-omics’ assays, expertise in computational biology needed to analyze and integrate the high-dimensional, multiscale data sets produced by these platforms is often not readily available. We propose to provide essential support for high-dimensional, multiscale data analysis and integration to facilitate use of ‘-omics’ technologies among Emory/Georgia TRAC investigators. The Systems Biology Core will accomplish this by serving as a single point of contact (concierge function) to investigators of the Emory/Georgia TRAC, and facilitating access to a wide array of ‘-omics’ technologies for specific experimental designs. Using established computational pipelines, we will provide training to new investigators on methods in high-dimensional data analysis and data integration in this increasingly essential area of basic and translational research. The specific aims of the BISB Core are: 1) to provide a single point of contact structure for data acquisition, management, and analysis for all ‘-omics’ platforms to TRAC investigators; 2) To provide training and educational resources to TRAC members to carry out cutting edge experiments using ‘- omics’ technologies and implement associated computational pipelines; and 3) to develop and implement novel multiomics assays and associated computational models to advance TB research. We will strive to nurture a collaborative research environment among Emory/Georgia TRAC investigators by facilitating the use and implementation of cutting edge multiomics assays to advance TB research and train the next generation of TB researchers.

生物信息学和综合系统生物学(系统生物学)核心将代表一个完整的埃默里/佐治亚州TRAC的组成部分。虽然埃默里/佐治亚州结核病研究的个别成员社区在合作结核病研究、获取系统中的尖端方法方面有着良好的记录生物并不是很容易理解的。尽管埃默里/格鲁吉亚核心预算资源调拨目标的伙伴机构主办了进行组学分析的各种核心设施，需要分析的计算生物学专业知识而集成由这些平台产生的高维、多尺度的数据集通常并不容易可用。我们建议为高维、多尺度数据分析和整合，以促进埃默里/佐治亚州TRAC调查人员使用“组学”技术。《系统》 BioCore将通过作为调查人员的单一联系点(礼宾职能)来实现这一点埃默里/佐治亚州TRAC，并促进获得针对特定领域的广泛的“组学”技术实验设计。利用已建立的计算管道，我们将为新的调查人员提供培训关于高维数据分析和数据集成的方法在这一日益重要的基础领域和翻译研究。BISB核心的具体目标是：1)提供单一联系点为TRAC调查员提供所有“组学”平台的数据获取、管理和分析的结构；2) 为核心目标咨询委员会成员提供培训和教育资源，利用‘- 组学的技术和实现相关的计算管道；以及3)开发和实施推进结核病研究的新的多组学分析和相关计算模型。我们将努力促进埃默里/佐治亚州TRAC调查人员之间的合作研究环境和实施尖端的多组学分析，以推进结核病研究和培训下一代结核病研究人员。