Core A: Administrative Core

核心A：行政核心

• 批准号: 10731277
• 负责人: Kristina De Paris
• 金额: $ 14.96万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10731277
• 关键词: Accounting; Administrative Personnel; Agreement; Automobile Driving; B-Lymphocytes; Biometry; Collaborations; Communication; Communities; Computer Analysis; Country; Data; Data Reporting; Databases; Decision Making; Dedications; Doctor of Philosophy; Documentation; Early identification; Ensure; Fostering; Funding; Goals; Grant; Guidelines; HIV; HIV vaccine; Human Resources; Individual; Infant; Infrastructure; Institution; International; Leadership; Macaca mulatta; Monitor; Occupational activity of managing finances; Output; Paris, France; Physicians; Policies; Principal Investigator; Productivity; Regulation; Reporting; Research; Research Activity; Research Personnel; Research Project Grants; Resource Allocation; Resource Sharing; Resources; Schedule; Scientist; Secure; Site; Strategic Planning; United States National Institutes of Health; Universities; Vaccination; Vaccine Design; data management; data sharing; knowledge integration; meetings; multidisciplinary; neutralizing antibody; nonhuman primate; operation; programs; success; symposium; synergism

ABSTRACT - Administrative Core The Administrative Core (Admin Core) will serve to coordinate, direct, and integrate the Program’s operations, facilitate synergy, and provide the infrastructure and oversight required to achieve the Program’s key scientific goal of identifying the determinants of HIV broadly neutralizing antibody precursors in infant rhesus macaques. The successful implementation and completion of this Program and its scientific goals will require a highly efficient and responsive Admin Core. The Admin Core will be essential for the success of the Program because it will provide 1) management of scientific projects and goals through coordination, relevant resources allocation, and efficient data sharing and reporting; 2) coordination of financial management through close communication and oversight; and 3) documentation of compliance, and thereby reduce the administrative burden of the individual Program components, while guaranteeing efficiency and synergy across all Projects and Cores. In addition, the Admin Core, with the guidance of the External Advisory Board (EAB) and NIH Program, will provide scientific and managerial oversight over the Program’s activities to ensure that steady progress is made towards scientific milestones. Specifically, Aim 1 of the Admin Core will provide overall coordination, communications and data management with dedicated personnel to ensure seamless collaboration and scientific progress and integrity. Aim 2 will ensure timely financial accounting and regulatory oversight to ensure compliance with institutional, federal, and international guidelines. By successfully completing its Aims, this Admin Core will ensure a unified research effort and support for the Program’s overall goal to identify the early determinants of broadly neutralizing antibody precursor induction in infant rhesus macaques. The Admin Core will guarantee efficient and coordinated conduct of all research activities and ensure high relevance of research goals as the field evolves to achieve the Program goal of optimizing HIV vaccine design for the induction of broadly neutralizing antibodies.

摘要-行政核心 行政核心（Admin Core）将负责协调、指导和整合该计划的运作， 促进协同作用，并提供实现该计划的关键科学目标所需的基础设施和监督。 目的是确定婴儿恒河猴中HIV广泛中和抗体前体的决定因素。 成功实施和完成这一计划及其科学目标将需要一个高度 高效、快速响应的管理核心。管理核心将是必不可少的计划的成功，因为 它将提供：1）通过协调，相关资源分配， 和有效的数据共享和报告; 2）通过密切沟通协调财务管理 3）记录遵守情况，从而减轻行政负担， 每个计划组件，同时保证所有项目和核心的效率和协同作用。 此外，在外部咨询委员会（EAB）和NIH计划的指导下，管理核心将 对该计划的活动进行科学和管理监督，以确保取得稳步进展 走向科学里程碑具体而言，管理核心的目标1将提供总体协调， 通信和数据管理，以确保无缝协作和科学 进步和正直。目标2将确保及时的财务会计和监管监督， 遵守机构、联邦和国际准则。 通过成功完成其目标，该管理核心将确保统一的研究工作和支持， 该计划的总体目标是确定广泛中和抗体前体诱导的早期决定因素， 幼年恒河猴行政核心将保证所有研究的有效和协调进行 活动，并确保随着该领域的发展，研究目标具有高度相关性，以实现该计划的目标 优化HIV疫苗设计，以诱导广泛中和抗体。