Core A: Administrative Core

核心A：行政核心

• 批准号: 10731277
• 负责人: Kristina De Paris
• 金额: $ 14.96万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10731277
• 关键词: Accounting; Administrative Personnel; Agreement; Automobile Driving; B-Lymphocytes; Biometry; Collaborations; Communication; Communities; Computer Analysis; Country; Data; Data Reporting; Databases; Decision Making; Dedications; Doctor of Philosophy; Documentation; Early identification; Ensure; Fostering; Funding; Goals; Grant; Guidelines; HIV; HIV vaccine; Human Resources; Individual; Infant; Infrastructure; Institution; International; Leadership; Macaca mulatta; Monitor; Occupational activity of managing finances; Output; Paris, France; Physicians; Policies; Principal Investigator; Productivity; Regulation; Reporting; Research; Research Activity; Research Personnel; Research Project Grants; Resource Allocation; Resource Sharing; Resources; Schedule; Scientist; Secure; Site; Strategic Planning; United States National Institutes of Health; Universities; Vaccination; Vaccine Design; data management; data sharing; knowledge integration; meetings; multidisciplinary; neutralizing antibody; nonhuman primate; operation; programs; success; symposium; synergism

ABSTRACT - Administrative Core The Administrative Core (Admin Core) will serve to coordinate, direct, and integrate the Program’s operations, facilitate synergy, and provide the infrastructure and oversight required to achieve the Program’s key scientific goal of identifying the determinants of HIV broadly neutralizing antibody precursors in infant rhesus macaques. The successful implementation and completion of this Program and its scientific goals will require a highly efficient and responsive Admin Core. The Admin Core will be essential for the success of the Program because it will provide 1) management of scientific projects and goals through coordination, relevant resources allocation, and efficient data sharing and reporting; 2) coordination of financial management through close communication and oversight; and 3) documentation of compliance, and thereby reduce the administrative burden of the individual Program components, while guaranteeing efficiency and synergy across all Projects and Cores. In addition, the Admin Core, with the guidance of the External Advisory Board (EAB) and NIH Program, will provide scientific and managerial oversight over the Program’s activities to ensure that steady progress is made towards scientific milestones. Specifically, Aim 1 of the Admin Core will provide overall coordination, communications and data management with dedicated personnel to ensure seamless collaboration and scientific progress and integrity. Aim 2 will ensure timely financial accounting and regulatory oversight to ensure compliance with institutional, federal, and international guidelines. By successfully completing its Aims, this Admin Core will ensure a unified research effort and support for the Program’s overall goal to identify the early determinants of broadly neutralizing antibody precursor induction in infant rhesus macaques. The Admin Core will guarantee efficient and coordinated conduct of all research activities and ensure high relevance of research goals as the field evolves to achieve the Program goal of optimizing HIV vaccine design for the induction of broadly neutralizing antibodies.

摘要 - 行政核心 管理核心（Admin Core）将负责协调、指导和整合计划的运营， 促进协同作用，并提供实现该计划关键科学目标所需的基础设施和监督 目标是确定幼年恒河猴中艾滋病毒广泛中和抗体前体的决定因素。 该计划及其科学目标的成功实施和完成需要高度的 高效且反应灵敏的管理核心。管理核心对于该计划的成功至关重要，因为 它将提供 1) 通过协调、相关资源分配来管理科学项目和目标， 高效的数据共享和报告； 2）密切沟通协调财务管理 和监督； 3) 合规文件，从而减轻管理机构的管理负担 各个项目组件，同时保证所有项目和核心的效率和协同作用。 此外，管理核心在外部顾问委员会 (EAB) 和 NIH 计划的指导下，将 对该计划的活动提供科学和管理监督，以确保取得稳步进展 迈向科学里程碑。具体来说，管理核心的目标 1 将提供整体协调， 由专职人员进行通信和数据管理，以确保无缝协作和科学 进步和诚信。目标 2 将确保及时的财务会计和监管监督，以确保 遵守机构、联邦和国际准则。 通过成功完成其目标，该管理核心将确保统一的研究工作和支持 该计划的总体目标是确定广泛中和抗体前体诱导的早期决定因素 恒河猴幼崽。管理核心将保证所有研究的高效和协调进行 随着该领域的发展，确保研究目标的高度相关性，以实现以下计划目标： 优化 HIV 疫苗设计以诱导广泛中和抗体。