5/14 APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Clinical Center

5/14 APOL1长期肾移植结果网络（APOLLO）临床中心

• 批准号: 10731162
• 负责人: Sumit Mohan
• 金额: $ 18.01万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-25 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10731162
• 关键词: APOL1 gene; Acceleration; Acute; Address; African American; African ancestry; Albumins; Allografting; American; Antibodies; Apolipoproteins; Bacterial Infections; Biopsy; Black race; Blood; Clinical; Clinical Data; Clinical Investigator; Collaborations; Collection; Consent; Cost Savings; Counseling; Creatinine; DNA; Data; Data Set; Disparity; Donor person; Education; Enrollment; Ensure; Environmental Risk Factor; Epidemiology; European; Evaluation; Face; Failure; Future; Genes; Genetic; Genotype; Geography; Goals; Graft Survival; HLA Antigens; Health; Health Care Costs; Healthcare; Hispanic; Immunology; Immunosuppression; Individual; Infrastructure; Kidney; Kidney Failure; Kidney Transplantation; Lesion; Living Donors; Longterm Follow-up; Measures; Medical; Medical center; Meridians; New England; Organ; Outcome; Outcomes Research; Participant; Pattern; Pediatric Hospitals; Pennsylvania; Phase; Phenotype; Philadelphia; Policies; Prevalence; Proteinuria; Quality of life; Recording of previous events; Recurrent disease; Registries; Renal function; Reporting; Research; Resources; Risk; Role; Safety; Serum; Site; Slide; Time; Transplant Recipients; Transplantation; United Network for Organ Sharing; United States National Institutes of Health; Universities; Urine; Variant; Virus Diseases; clinical center; cohort; data registry; digital pathology; ethnic difference; experience; follow-up; gene interaction; genetic risk factor; graft failure; high risk; improved; kidney biopsy; living kidney donor; member; multidisciplinary; novel; patient retention; post-transplant; primary outcome; programs; prospective; racial difference; recruit; repository; risk variant; secondary outcome; transplant centers

ABSTRACT The Columbia-Penn Clinical Consortium APOLLO-CC05 brings together an experienced multidisciplinary team of clinical investigators with expertise in the fields of transplant epidemiology, immunology, and genetics, as well as an extensive history of collaboration with the United Network for Organ Sharing (UNOS) and other CPCC member transplant programs. As a result, the CC05 is well suited to recruit and retain patients for longitudinal follow up for the APOL1 Long-term Kidney Transplantation Outcomes Research Network (APOLLO) Phase 2. This Clinical Center is composed of 11 transplant centers in four contiguous states (NY, NJ, CT and PA) in the Northeastern US. Our primary objective is to provide long-term follow up data on all APOLLO Phase 1 participants while continuing to enroll new African American or Black Hispanic living kidney donors (Aim 1). We will provide detailed clinical data (not currently available in any registry dataset) with the goal of identifying “second hits” and collect additional biospecimens (Urine albumin to creatinine ratio, blood, urine and biopsy slides) for Aim 2. We will partner with the SDRC to provide return of APOL1 genotype results to all participants who wish to receive them (Aim 3). We expect that Phase 2 of the APOLLO study will determine the impact of APOL1 risk variants in donors and recipients on kidney transplant outcomes and will create a unique cohort of African American living kidney donors with detailed clinical data and biospecimens as a resource for future studies.

摘要 哥伦比亚-宾夕法尼亚临床联盟Apollo-CC05汇集了一位经验丰富的 在移植领域拥有专业知识的多学科临床研究人员团队 流行病学、免疫学和遗传学，以及与 器官共享联合网络(UNOS)和其他CPCC成员移植计划。 因此，CC05非常适合招募和留住患者进行纵向随访 APOL1长期肾脏移植结果研究网络(Apollo)第二阶段。 该临床中心由四个相邻州(NY、NJ、CT)的11个移植中心组成 和PA)在美国东北部。我们的主要目标是提供长期的跟踪数据 所有阿波罗第一阶段参与者，同时继续招收新的非裔美国人或黑人 西班牙裔活体肾脏捐赠者(目标1)。我们将提供详细的临床数据(目前不会 在任何注册表数据集中都可用)，其目标是识别“二次命中”并收集其他 用于目标2的生物标本(尿白蛋白与肌酐的比率、血液、尿液和活检切片)。 将与国家发改委合作，向所有符合以下条件的参与者提供APOL1基因结果的返回 希望收到他们(目标3)。我们预计阿波罗研究的第二阶段将决定 供受者中APOL1风险变异对肾移植结局和意愿的影响 创建一个独特的非裔美国活体肾脏捐赠者队列，提供详细的临床数据和 生物标本作为未来研究的资源。

项目成果

Radical Transparency to Improve Equity in the Kidney Allocation System.

• DOI: 10.34067/kid.0000000000000327
• 发表时间: 2024-01-01
• 期刊: Kidney360
• 作者: Husain SA;Adler JT;Mohan S
• 通讯作者: Mohan S

Reversal of Donor Hepatitis C Virus-Related Mesangial Proliferative GN in a Kidney Transplant Recipient.

肾移植受者体内供体丙型肝炎病毒相关的系膜增殖性肾小球肾炎的逆转。

• DOI: 10.1681/asn.2020060820
• 发表时间: 2020
• 期刊: Journal of the American Society of Nephrology : JASN
• 作者: Khairallah,Pascale;Kudose,Satoru;Morris,HeatherK;Ratner,LloydE;Mohan,Sumit;Radhakrishnan,Jai;Chang,Jae-Hyung
• 通讯作者: Chang,Jae-Hyung

Why the National Academies Got it Wrong about Changing Preemptive Listing Priority for Kidney Transplantation.

为什么美国国家科学院在改变肾脏移植的优先上市优先权方面出现了错误。

• DOI: 10.1681/asn.0000000000000209
• 发表时间: 2023
• 期刊: Journal of the American Society of Nephrology : JASN
• 作者: Schold,JesseD;Huml,AnneM;Husain,SAli;Mohan,Sumit
• 通讯作者: Mohan,Sumit

Impact of Extending Eligibility for Reinstatement of Waiting Time After Early Allograft Failure: A Decision Analysis.

• DOI: 10.1053/j.ajkd.2021.07.023
• 发表时间: 2022-03
• 期刊: American journal of kidney diseases : the official journal of the National Kidney Foundation
• 作者: Husain SA;King KL;Adler JT;Mohan S;Perotte R
• 通讯作者: Perotte R

Financial impact of delayed graft function in kidney transplantation.

• DOI: 10.1111/ctr.14022
• 发表时间: 2020-10
• 期刊: Clinical transplantation
• 影响因子: 2.1
• 作者: Kim DW;Tsapepas D;King KL;Husain SA;Corvino FA;Dillon A;Wang W;Mayne TJ;Mohan S
• 通讯作者: Mohan S