Core C - Integrated Quantitative Science (IQS)

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CORE C: ABSTRACT The mission of the Integrated Quantitative Science (IQS) Core is to provide state-of-the-art data management, study design, and statistical analysis support for the UNC Pancreatic Cancer SPORE translational research projects. This centralized core will provide the technical skills for the statistical analysis of clinical, translational, and multi-platform genomic data from individual research projects to provide a broad clinical and molecular portrait of pancreatic cancer. Results from each project will inform the design and analysis of a future SMART trial, which will involve state-of-the-art clinical trial design and machine learning methods to determine the best sequence of treatments, tailored to individual patient-level characteristics. Complementary skills possessed by the Core faculty will also lead to the application and development of (as needed) cutting-edge approaches for cross-platform data integration and high-dimensional biomarker discovery to facilitate patient subtyping and optimize clinical decision-making. This Core will provide appropriate input into design, management, and analysis to ensure that SPORE investigators pursue the most promising lines of translational research.