Core C - Integrated Quantitative Science (IQS)

核心C：抽象 综合量化科学(IQS)核心的使命是提供最先进的数据管理， 为北卡罗来纳大学胰腺癌孢子翻译研究提供研究设计和统计分析支持 项目。这一集中的核心将为临床、翻译、 以及来自单个研究项目的多平台基因组数据提供了广泛的临床和分子基础 胰腺癌的肖像。每个项目的结果将为未来SMART的设计和分析提供参考 试验，这将涉及最先进的临床试验设计和机器学习方法，以确定最佳 治疗顺序，根据个别患者水平的特点量身定做。拥有的互补技能 核心教员还将领导(根据需要)尖端方法的应用和开发 跨平台数据集成和高维生物标志物发现，以促进患者亚型和 优化临床决策。此核心将为设计、管理和 分析，以确保孢子研究人员从事最有前途的翻译研究。

CORE C: ABSTRACT The mission of the Integrated Quantitative Science (IQS) Core is to provide state-of-the-art data management, study design, and statistical analysis support for the UNC Pancreatic Cancer SPORE translational research projects. This centralized core will provide the technical skills for the statistical analysis of clinical, translational, and multi-platform genomic data from individual research projects to provide a broad clinical and molecular portrait of pancreatic cancer. Results from each project will inform the design and analysis of a future SMART trial, which will involve state-of-the-art clinical trial design and machine learning methods to determine the best sequence of treatments, tailored to individual patient-level characteristics. Complementary skills possessed by the Core faculty will also lead to the application and development of (as needed) cutting-edge approaches for cross-platform data integration and high-dimensional biomarker discovery to facilitate patient subtyping and optimize clinical decision-making. This Core will provide appropriate input into design, management, and analysis to ensure that SPORE investigators pursue the most promising lines of translational research.