Core C - Integrated Quantitative Science (IQS)

核心 C：摘要 集成定量科学 (IQS) 核心的使命是提供最先进的数据管理、 为北卡罗来纳大学胰腺癌 SPORE 转化研究提供研究设计和统计分析支持 项目。这个集中核心将为临床、转化、 以及来自各个研究项目的多平台基因组数据，以提供广泛的临床和分子信息 胰腺癌的肖像。每个项目的结果将为未来 SMART 的设计和分析提供信息 试验，其中将涉及最先进的临床试验设计和机器学习方法来确定最佳方案 根据患者个体特征量身定制治疗顺序。拥有的互补技能 核心教师还将领导（根据需要）尖端方法的应用和开发 跨平台数据集成和高维生物标志物发现，以促进患者亚型分析和 优化临床决策。该核心将为设计、管理和 分析，以确保 SPORE 研究人员追求最有前途的转化研究方向。

CORE C: ABSTRACT The mission of the Integrated Quantitative Science (IQS) Core is to provide state-of-the-art data management, study design, and statistical analysis support for the UNC Pancreatic Cancer SPORE translational research projects. This centralized core will provide the technical skills for the statistical analysis of clinical, translational, and multi-platform genomic data from individual research projects to provide a broad clinical and molecular portrait of pancreatic cancer. Results from each project will inform the design and analysis of a future SMART trial, which will involve state-of-the-art clinical trial design and machine learning methods to determine the best sequence of treatments, tailored to individual patient-level characteristics. Complementary skills possessed by the Core faculty will also lead to the application and development of (as needed) cutting-edge approaches for cross-platform data integration and high-dimensional biomarker discovery to facilitate patient subtyping and optimize clinical decision-making. This Core will provide appropriate input into design, management, and analysis to ensure that SPORE investigators pursue the most promising lines of translational research.