Core C - Integrated Quantitative Science (IQS)

核心 C - 综合定量科学 (IQS)

• 批准号: 10705601
• 负责人: MICHAEL R KOSOROK
• 金额: $ 18.71万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-16 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10705601
• 关键词: Address; Animals; Applications Grants; Biometry; Characteristics; Clinical; Clinical Data; Clinical Protocols; Clinical Trials; Clinical Trials Design; Data; Development; Documentation; Ensure; Faculty; Future; Gene Expression Profiling; Genomics; Human; Individual; Maintenance; Malignant neoplasm of pancreas; Medicine; Methodology; Methods; Mission; Molecular; Outcome; Participant; Pathology; Portraits; Preparation; Program Development; Proteomics; Public Health; Publications; Quality Control; Reporting; Reproducibility; Research Design; Research Personnel; Research Project Grants; Sample Size; Science; Services; Statistical Data Interpretation; Statistical Methods; Technical Expertise; Time; Tissue Procurements; Translational Research; analytical tool; biomarker discovery; career development; clinical decision-making; data integration; data management; database design; design; diverse data; genomic data; genomic platform; high dimensionality; individual patient; innovation; machine learning method; multiple data types; patient response; patient subsets; research study; response; skills; treatment response; treatment strategy; tumor

CORE C: ABSTRACT The mission of the Integrated Quantitative Science (IQS) Core is to provide state-of-the-art data management, study design, and statistical analysis support for the UNC Pancreatic Cancer SPORE translational research projects. This centralized core will provide the technical skills for the statistical analysis of clinical, translational, and multi-platform genomic data from individual research projects to provide a broad clinical and molecular portrait of pancreatic cancer. Results from each project will inform the design and analysis of a future SMART trial, which will involve state-of-the-art clinical trial design and machine learning methods to determine the best sequence of treatments, tailored to individual patient-level characteristics. Complementary skills possessed by the Core faculty will also lead to the application and development of (as needed) cutting-edge approaches for cross-platform data integration and high-dimensional biomarker discovery to facilitate patient subtyping and optimize clinical decision-making. This Core will provide appropriate input into design, management, and analysis to ensure that SPORE investigators pursue the most promising lines of translational research.

核心C：摘要 综合定量科学（IQS）核心的使命是提供最先进的数据管理， 研究设计和统计分析支持胰腺癌SPORE转化研究 项目这个集中的核心将提供临床，翻译， 和多平台的基因组数据，从个人的研究项目，以提供广泛的临床和分子 胰腺癌的症状每个项目的结果将为未来SMART的设计和分析提供信息 试验，这将涉及最先进的临床试验设计和机器学习方法，以确定最佳的 治疗顺序，针对个体患者水平特征定制。拥有的补充技能 核心教师还将导致（根据需要）尖端方法的应用和开发， 跨平台数据整合和高维生物标志物发现，以促进患者分型， 优化临床决策。该核心将为设计、管理和 分析，以确保SPORE研究人员追求最有前途的转化研究路线。