Cardiovascular Disparities among Bereaved Latinos and Non-Latino Whites and Factors that Facilitate Resilience: A Biobehavioral Approach

失去亲人的拉丁裔和非拉丁裔白人之间的心血管差异以及促进复原力的因素：生物行为方法

• 批准号: 10704855
• 负责人: Luz Maria Garcini
• 金额: $ 14.81万
• 依托单位: RICE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-16 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10704855
• 关键词: Acute; Adult; Anti-Inflammatory Agents; Bereavement; Biological Markers; Cardiovascular Diseases; Cardiovascular system; Cells; Chronic; Data; Development; Dimensions; Disparity; Emotions; Enrollment; Ethnic Origin; Excess Mortality; Exposure to; Faculty; Feedback; Five-Year Plans; Fostering; Foundations; Funding; Glucocorticoids; Goals; Grief reaction; Immune; Immune system; Individual; Inflammation; Inflammatory Response; Institution; Intervention; Interview; K-Series Research Career Programs; Knowledge; Latino; Latino Population; Lead; Life; Literature; Longitudinal Studies; Measures; Mediator; Medical; Mentors; Mentorship; Methods; Modeling; Morbidity - disease rate; Persons; Psychoneuroimmunology; Research; Resistance; Resources; Risk; Risk Assessment; Science; Spouses; Stress and Coping; Stressful Event; Surveys; Symptoms; Time; Training; Visit; Vulnerable Populations; biobehavior; burden of illness; cardiovascular disorder risk; career; clinically significant; community based research; coping; design; ethnic difference; ethnic disparity; experience; health determinants; health disparity; innovation; longitudinal design; mortality; mortality risk; multidisciplinary; novel; promote resilience; protective factors; resilience; skills; social health determinants; sociocultural determinant; steroid hormone; stressor; therapy development

ABSTRACT The proposed five-year plan for Dr. Luz Garcini's K01 Mentor Career Development Award will help launch her independent research career in biobehavioral health disparities and cardiovascular disease (CVD) risk. In the proposed project, Dr. Garcini aims at filling a gap in the literature by understanding how bereavement increases CVD risk, including detecting relevant ethnic disparities and identifying protective factors during this difficult life transition. The proposed training and mentoring plan will supplement Dr. Garcini's expertise in health disparities and community-based research with a foundation in CVD and psychoneuroimmunology (PNI) at premiere academic and medical institutions under the mentorship of renowned experts. The proposed research will use data from a longitudinal study among 96 recently (<2 months) bereaved adults (50% Latino, 50% Non-Latino White) with CVD risk assessments (i.e., glucocorticoid (GC) resistance and inflammation) done at baseline, 3, 6, and 12 months post enrollment. Survey measures of relevant mediators and moderators will take place at each time point, with a qualitative interview done after the last visit. The proposed project will draw on Dr. Garcini's expertise, along with a mentoring team at the forefront of biomedical science, to conduct the following aims using an interdisciplinary and culturally sensitive approach. AIM 1. To assess ethnic differences (Latinos, non-Latino Whites) in the association between grief symptoms and CVD risk (GC resistance and inflammation) among bereaved adults cross-sectionally and longitudinally. Hypothesis 1. The strength of the association between grief symptoms and CVD risk will be relatively stronger among Latinos compared to Non-Latino Whites. AIM 2. To identify contextual and cultural factors that facilitate coping with bereavement among Latinos and non-Latino Whites. AIM 3. To supplement Dr. Garcini's expertise in community-based research and health disparities with a foundation in CVD and psychoneuroimmunology (PNI) at premiere institutions and under the mentorship of renowned experts with the goal of increasing faculty diversity in the biomedical sciences. The proposed studies will offer an invaluable context to apply these concepts in a meaningful way—integrating didactics and experience, with the mentorship of an advising team of experts. The proposed research will provide novel information about mechanisms and predictors that underlie CVD risk in a vulnerable population about which little is known, while also identifying protective factors that foster resilience. The longitudinal design will provide valuable information to identify critical time points for intervention. The interdisciplinary training plan will equip Dr. Garcini with extensive knowledge of CVD and PNI skills to devote her career to the study of biobehavioral health disparities, CVD risk, and social determinants of health, which is needed to inform the development of interventions aimed at reducing disease burden.

摘要 Luz Garcini博士的K01导师职业发展奖的拟议五年计划将有助于启动 她在生物行为健康差异和心血管疾病（CVD）风险方面的独立研究生涯。在 Garcini博士提出的项目旨在通过了解丧亲之痛如何填补文献中的空白。 增加心血管疾病的风险，包括检测相关的种族差异，并确定在此期间的保护因素， 艰难的人生过渡拟议的培训和指导计划将补充Garcini博士的专业知识， 健康差异和以CVD和心理神经免疫学（PNI）为基础的社区研究 在著名专家的指导下，在一流的学术和医疗机构工作。 这项拟议中的研究将使用96名最近（<2个月）失去亲人的纵向研究数据 成年人（50%拉丁裔，50%非拉丁裔白色）CVD风险评估（即，糖皮质激素抵抗 和炎症）。相关调查措施 调解员和主持人将在每个时间点进行，并在最后一次访问后进行定性访谈。 拟议的项目将利用Garcini博士的专业知识，沿着一个指导小组， 在生物医学科学方面，利用跨学科和文化敏感的方法实现以下目标。 AIM 1.评估种族差异（拉丁美洲人，非拉丁美洲白人）之间的关联悲伤 症状和CVD风险（GC抵抗和炎症）在失去亲人的成年人中的横断面 纵向。假设1.悲伤症状与心血管疾病风险之间的关联强度 与非拉丁裔白人相比，拉丁裔白人的影响力相对更强。 AIM 2.确定有助于处理丧亲之痛的背景和文化因素， 拉丁裔和非拉丁裔白人。 AIM 3.为了补充Garcini博士在社区研究和健康差异方面的专业知识 在CVD和心理神经免疫学（PNI）的基础上，在一流的机构和 知名专家的指导，以增加生物医学领域的教师多样性为目标 以理工科为重拟议的研究将提供一个宝贵的背景下，应用这些概念，在一个有意义的 将教学方法和经验相结合，并由专家咨询小组提供指导。 这项研究将为CVD的机制和预测因素提供新的信息 风险的脆弱人群，这是鲜为人知的，同时也确定保护因素， resilience.纵向设计将提供有价值的信息，以确定关键的时间点， 干预跨学科的培训计划将使Garcini博士具备CVD和PNI的广泛知识 她的职业生涯致力于研究生物行为健康差异，心血管疾病风险和社会决定因素， 这是为制定旨在减少疾病负担的干预措施提供信息所必需的。