Cardiovascular Disparities among Bereaved Latinos and Non-Latino Whites and Factors that Facilitate Resilience: A Biobehavioral Approach

失去亲人的拉丁裔和非拉丁裔白人之间的心血管差异以及促进复原力的因素：生物行为方法

• 批准号: 10704855
• 负责人: Luz Maria Garcini
• 金额: $ 14.81万
• 依托单位: RICE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-16 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10704855
• 关键词: Acute; Adult; Anti-Inflammatory Agents; Bereavement; Biological Markers; Cardiovascular Diseases; Cardiovascular system; Cells; Chronic; Data; Development; Dimensions; Disparity; Emotions; Enrollment; Ethnic Origin; Excess Mortality; Exposure to; Faculty; Feedback; Five-Year Plans; Fostering; Foundations; Funding; Glucocorticoids; Goals; Grief reaction; Immune; Immune system; Individual; Inflammation; Inflammatory Response; Institution; Intervention; Interview; K-Series Research Career Programs; Knowledge; Latino; Latino Population; Lead; Life; Literature; Longitudinal Studies; Measures; Mediator; Medical; Mentors; Mentorship; Methods; Modeling; Morbidity - disease rate; Persons; Psychoneuroimmunology; Research; Resistance; Resources; Risk; Risk Assessment; Science; Spouses; Stress and Coping; Stressful Event; Surveys; Symptoms; Time; Training; Visit; Vulnerable Populations; biobehavior; burden of illness; cardiovascular disorder risk; career; clinically significant; community based research; coping; design; ethnic difference; ethnic disparity; experience; health determinants; health disparity; innovation; longitudinal design; mortality; mortality risk; multidisciplinary; novel; promote resilience; protective factors; resilience; skills; social health determinants; sociocultural determinant; steroid hormone; stressor; therapy development

ABSTRACT The proposed five-year plan for Dr. Luz Garcini's K01 Mentor Career Development Award will help launch her independent research career in biobehavioral health disparities and cardiovascular disease (CVD) risk. In the proposed project, Dr. Garcini aims at filling a gap in the literature by understanding how bereavement increases CVD risk, including detecting relevant ethnic disparities and identifying protective factors during this difficult life transition. The proposed training and mentoring plan will supplement Dr. Garcini's expertise in health disparities and community-based research with a foundation in CVD and psychoneuroimmunology (PNI) at premiere academic and medical institutions under the mentorship of renowned experts. The proposed research will use data from a longitudinal study among 96 recently (<2 months) bereaved adults (50% Latino, 50% Non-Latino White) with CVD risk assessments (i.e., glucocorticoid (GC) resistance and inflammation) done at baseline, 3, 6, and 12 months post enrollment. Survey measures of relevant mediators and moderators will take place at each time point, with a qualitative interview done after the last visit. The proposed project will draw on Dr. Garcini's expertise, along with a mentoring team at the forefront of biomedical science, to conduct the following aims using an interdisciplinary and culturally sensitive approach. AIM 1. To assess ethnic differences (Latinos, non-Latino Whites) in the association between grief symptoms and CVD risk (GC resistance and inflammation) among bereaved adults cross-sectionally and longitudinally. Hypothesis 1. The strength of the association between grief symptoms and CVD risk will be relatively stronger among Latinos compared to Non-Latino Whites. AIM 2. To identify contextual and cultural factors that facilitate coping with bereavement among Latinos and non-Latino Whites. AIM 3. To supplement Dr. Garcini's expertise in community-based research and health disparities with a foundation in CVD and psychoneuroimmunology (PNI) at premiere institutions and under the mentorship of renowned experts with the goal of increasing faculty diversity in the biomedical sciences. The proposed studies will offer an invaluable context to apply these concepts in a meaningful way—integrating didactics and experience, with the mentorship of an advising team of experts. The proposed research will provide novel information about mechanisms and predictors that underlie CVD risk in a vulnerable population about which little is known, while also identifying protective factors that foster resilience. The longitudinal design will provide valuable information to identify critical time points for intervention. The interdisciplinary training plan will equip Dr. Garcini with extensive knowledge of CVD and PNI skills to devote her career to the study of biobehavioral health disparities, CVD risk, and social determinants of health, which is needed to inform the development of interventions aimed at reducing disease burden.

抽象的 Luz Garcini博士的K01导师职业发展奖提议的五年计划将有助于启动 她在生物行为健康差异和心血管疾病（CVD）风险方面的独立研究生涯。在 拟议的项目Garcini博士旨在通过了解丧亲是如何填补文献中的空白 增加CVD风险，包括检测相关的种族差异并在此期间识别保护因素 艰难的生活过渡。拟议的培训和心理计划将补充Garcini博士的专业知识 健康分布和基于社区的研究，凭借CVD和Psychoneuromummummummumanology（PNI）的基础 在著名专家的心态下，在首映学术和医疗机构上。 拟议的研究将使用最近96个（<2个月）的纵向研究中的数据 成人（50％拉丁裔，50％非拉丁裔白色），具有CVD风险评估（即糖皮质激素（GC）抗性 在入学后3、6和12个月的基线，3、6和12个月进行炎症）。相关的调查措施 调解员和主持人将在每个时间点进行，并在上次访问后进行定性采访。 拟议的项目将借鉴加西尼博士的专业知识，以及一个心理团队 生物医学科学，使用跨学科和文化敏感的方法进行以下目的。 目的1。评估种族之间的种族差异（拉丁裔，非拉丁裔白人） 丧亲成年人的症状和CVD风险（GC抵抗和炎症）横截面 和纵向。假设1。CRIEV症状与CVD风险之间的关联强度 与非拉丁美洲白人相比，拉丁美洲人在拉丁美洲人的情况相对较强。 目标2。确定有助于应对丧亲的上下文和文化因素 拉丁美洲人和非拉丁裔白人。 目的3。补充加西尼博士在社区研究和健康分布方面的专业知识 在首映机构和下 著名专家的遗产，目的是增加生物医学的教师多样性 科学。拟议的研究将提供宝贵的背景，以将这些概念应用于有意义的 方式 - 通过专家咨询团队的指导，整合教学和经验。 拟议的研究将提供有关CVD基础的机制和预测因素的新颖信息 在脆弱人群中，风险鲜为人知，同时还可以确定受保护因素 弹力。纵向设计将提供有价值的信息，以确定关键时间点 干涉。跨学科培训计划将为Garcini博士提供有关CVD和PNI的广泛知识 将她的职业生涯用于研究生物行为健康差异，CVD风险和社会决定者的技能 健康，这需要告知旨在减少疾病伯恩的干预措施的发展。