Cardiovascular Disparities among Bereaved Latinos and Non-Latino Whites and Factors that Facilitate Resilience: A Biobehavioral Approach

摘要 Luz Garcini博士的K01导师职业发展奖拟议的五年计划将有助于启动 她在生物行为健康差异和心血管疾病(CVD)风险方面的独立研究生涯。在……里面 拟议的项目，加尔奇尼博士旨在通过了解丧亲之痛如何填补文献中的空白 增加心血管疾病的风险，包括检测相关的种族差异并在此期间确定保护因素 艰难的人生转型。拟议的培训和指导计划将补充Garcini博士在 健康差异和以心血管疾病和心理神经免疫学(PNI)为基础的社区研究 在著名专家的指导下，在首屈一指的学术和医疗机构。 拟议的研究将使用从96个最近(&lt；2个月)失去亲人的纵向研究的数据 有心血管疾病风险评估(即糖皮质激素抵抗)的成年人(50%拉丁裔，50%非拉丁裔白人) 和炎症)在基线、登记后3个月、6个月和12个月进行。相关的调查措施 调解人和主持人将在每个时间点进行，最后一次访问后将进行定性访谈。 拟议的项目将利用加西尼博士的专业知识，以及处于 生物医学科学，使用跨学科和文化敏感的方法来实现下列目标。 目的1.评估种族差异(拉丁裔、非拉丁裔白人)与悲伤之间的联系 失去亲人的成年人的症状和心血管疾病风险(GC抵抗和炎症) 而且是纵向的。假设1.悲伤症状和心血管疾病风险之间的联系的强度 与非拉美裔白人相比，拉美裔美国人的支持率相对较高。 目标2.确定有助于处理以下人员丧亲问题的背景和文化因素 拉丁裔和非拉丁裔白人。 目标3.补充Garcini博士在社区研究和健康差距方面的专业知识 以心血管疾病和心理神经免疫学(PNI)为基础，在首映机构和 指导知名专家，目标是增加生物医学领域的教师多样性 科学。拟议的研究将提供宝贵的背景，以便将这些概念应用于有意义的 Way-在专家顾问团队的指导下，将教学和经验结合在一起。 这项拟议的研究将为心血管疾病的发病机制和预测因素提供新的信息。 对脆弱人群的风险知之甚少，同时也确定了促进 恢复力。纵向设计将提供有价值的信息，以确定关键时间点 干预。跨学科培训计划将使Garcini博士具备丰富的心血管疾病和PNI知识 她的职业生涯致力于生物行为健康差异、心血管疾病风险和社会决定因素的研究 健康，这是制定旨在减轻疾病负担的干预措施所必需的。

ABSTRACT The proposed five-year plan for Dr. Luz Garcini's K01 Mentor Career Development Award will help launch her independent research career in biobehavioral health disparities and cardiovascular disease (CVD) risk. In the proposed project, Dr. Garcini aims at filling a gap in the literature by understanding how bereavement increases CVD risk, including detecting relevant ethnic disparities and identifying protective factors during this difficult life transition. The proposed training and mentoring plan will supplement Dr. Garcini's expertise in health disparities and community-based research with a foundation in CVD and psychoneuroimmunology (PNI) at premiere academic and medical institutions under the mentorship of renowned experts. The proposed research will use data from a longitudinal study among 96 recently (<2 months) bereaved adults (50% Latino, 50% Non-Latino White) with CVD risk assessments (i.e., glucocorticoid (GC) resistance and inflammation) done at baseline, 3, 6, and 12 months post enrollment. Survey measures of relevant mediators and moderators will take place at each time point, with a qualitative interview done after the last visit. The proposed project will draw on Dr. Garcini's expertise, along with a mentoring team at the forefront of biomedical science, to conduct the following aims using an interdisciplinary and culturally sensitive approach. AIM 1. To assess ethnic differences (Latinos, non-Latino Whites) in the association between grief symptoms and CVD risk (GC resistance and inflammation) among bereaved adults cross-sectionally and longitudinally. Hypothesis 1. The strength of the association between grief symptoms and CVD risk will be relatively stronger among Latinos compared to Non-Latino Whites. AIM 2. To identify contextual and cultural factors that facilitate coping with bereavement among Latinos and non-Latino Whites. AIM 3. To supplement Dr. Garcini's expertise in community-based research and health disparities with a foundation in CVD and psychoneuroimmunology (PNI) at premiere institutions and under the mentorship of renowned experts with the goal of increasing faculty diversity in the biomedical sciences. The proposed studies will offer an invaluable context to apply these concepts in a meaningful way—integrating didactics and experience, with the mentorship of an advising team of experts. The proposed research will provide novel information about mechanisms and predictors that underlie CVD risk in a vulnerable population about which little is known, while also identifying protective factors that foster resilience. The longitudinal design will provide valuable information to identify critical time points for intervention. The interdisciplinary training plan will equip Dr. Garcini with extensive knowledge of CVD and PNI skills to devote her career to the study of biobehavioral health disparities, CVD risk, and social determinants of health, which is needed to inform the development of interventions aimed at reducing disease burden.