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ALACRITY for Late- and Mid-Life Mood Disorders

ALACRITY 治疗晚年和中年情绪障碍

基本信息

批准号：
10016855
负责人：
JO ANNE SIREY
金额：
$ 140.64万
依托单位：
WEILL MEDICAL COLL OF CORNELL UNIV
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-22 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10016855
关键词：
Address Adherence Administrator Adult Area Behavior Therapy Big Data Biometry Caring Clinical Communities Community Workers Complex Data Disease Economic Policy Effectiveness Elder Abuse Elderly Ensure Funding Grant Health Services Research Healthcare Incubators Intervention Intervention Studies Lead Learning Medical Mental Health Methodology Methods Mission Modeling Monitor Mood Disorders Morbidity - disease rate National Institute of Mental Health Neurobiology Nonpharmacologic Therapy Persons Pharmacotherapy Policies Population Poverty Primary Health Care Process Productivity Quality Control Research Research Personnel Research Training Site Structure Testing Work analytical method base care costs career development community intervention community setting design disability health care model health economics improved innovation middle age mobile computing mortality novel social therapy development uptake

项目摘要

ALACRITY CENTER ABSTRACT The rapid increase of older persons (73% increase anticipated in US by 2020) and the diseases and disabilities complicating their care make research in this area a national priority. We focus on late- and mid-life mood disorders because they are the leading cause of disability, increase medical morbidity and mortality, cause suffering, and increase the cost of care. Pharmacotherapy addresses the needs of no more than half of these persons and most non-pharmacological therapies are complex and have limited scalability and reach. We propose to put into action a novel model of deployment-based behavioral interventions and implementation, streamlined based on neurobiology models and augmented by mobile technology. Rather than focusing exclusively on uptake and sustainability of available interventions, many of which are too complex for community use, we are working to both simplify the treatments themselves and improve their delivery. Accordingly, our model: 1) Targets groups identified by consumers, community partners, and our team. 2) Develops its interventions jointly with community partners and a transdisciplinary team and uses neurobiological concepts as a “simplification rule” for streamlining behavioral interventions so that they can be used by community clinicians; 3) integrates mobile technology to community interventions at the assessment, the intervention, and the adherence monitoring levels; and 4) tests its interventions at community sites using community clinicians to shorten the way to uptake and sustainability. To maximize our impact, we will work both in settings in which most older and middle-aged people receive care (primary care) and in settings serving persons with special clinical (elder mistreatment) and social needs (poverty). The Center's approach is a clear departure from traditional intervention and services research and can lead to a revolutionary change in how the field thinks about T2 intervention development and deployment in the community. Our Methods Core will provide quality control for the Center's projects, serve as an incubator for innovative approaches to novel design and analytic methods that enhance the information yield of effectiveness data. It also uses big-data to aid the identification of populations in need of novel interventions, provides policy support, and integrates novel mobile technology approaches to community interventions. The Core will also evaluate the Center's productivity and impact on the field and disseminate its methodological advances. We are confident that we can meet the challenges of this work because of our 20 years of working together with stakeholders and community partners in intervention planning and implementation supported by 4 consecutive NIMH-funded Center grants, a large portfolio of independently funded studies, and a strong record of research training and career development of junior investigators.

快捷性中心摘要老年人口的快速增长(预计到2020年美国将增加73%)以及疾病和使他们的护理复杂化的残疾使这一领域的研究成为国家优先事项。我们关注的是中老年情绪障碍，因为它们是残疾的主要原因，增加了医疗发病率和死亡率，造成痛苦，增加护理成本。药物疗法解决了不超过一半的人的需求这些人和大多数非药物疗法都很复杂，可伸缩性和覆盖范围有限。我们建议实施一种基于部署的行为干预的新模式，并根据神经生物学模型简化实施，并通过移动技术进行增强。宁可而不是只关注可用干预措施的吸收和可持续性，其中许多干预措施过于对于社区使用，我们正在努力简化治疗本身并改进其送货。因此，我们的模型：1)以消费者、社区合作伙伴和我们的一队。2)与社区合作伙伴和跨学科团队共同制定干预措施，并使用神经生物学概念作为简化行为干预的“简化规则”，以便它们能够由社区临床医生使用；3)在评估中将移动技术整合到社区干预中，干预措施和遵守监测水平；以及4)在社区站点测试其干预措施社区临床医生缩短吸收和可持续发展的途径。为了最大限度地发挥我们的影响力，我们将努力无论是在大多数老年人和中年人接受护理(初级保健)的环境中还是在环境中为有特殊临床(虐待老年人)和社会需求(贫困)的人提供服务。该中心的方法与传统的干预和服务研究明显背道而驰，可以带来革命性的变化现场如何看待T2干预在社区中的开发和部署。我们的方法核心将为中心的项目提供质量控制，作为创新的孵化器寻求新的设计和分析方法，以提高有效性数据的信息产量。它还使用大数据来帮助识别需要新干预措施的人口，提供政策支持和整合新的移动技术方法进行社区干预。核心还将评估该中心在实地的生产力和影响，并传播其方法上的进步。我们有信心迎接这项工作的挑战，因为我们共同工作了20年与利益相关者和社区合作伙伴一起参与干预计划和实施，由4人提供支持 NIMH连续资助的中心赠款，大量独立资助的研究项目，以及强大的初级调查员的研究、培训和职业发展记录。

项目成果

期刊论文数量（37）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Effects of Geography on Risk for Future Suicidal Ideation and Attempts Among Children and Youth.

DOI：
10.1016/j.jaacop.2023.07.002
发表时间：
2023-11
期刊：
JAACAP open
影响因子：
0
作者：
Xi, Wenna;Banerjee, Samprit;Zima, Bonnie T;Alexopoulos, George S;Olfson, Mark;Xiao, Yunyu;Pathak, Jyotishman
通讯作者：
Pathak, Jyotishman

COVID-19 infection rates in patients referred for psychiatric admission during a regional surge: The case for universal testing.

DOI：
10.1016/j.psychres.2021.113833
发表时间：
2021-04
期刊：
Psychiatry research
影响因子：
11.3
作者：
Brody BD;Shi Z;Shaffer C;Eden D;Wyka K;Alexopoulos GS;Parish SJ;Kanellopoulos D
通讯作者：
Kanellopoulos D

Burnout and the Quantified Workplace: Tensions around Personal Sensing Interventions for Stress in Resident Physicians.

DOI：
10.1145/3555531
发表时间：
2022-11-01
期刊：
Proceedings of the ACM on human-computer interaction
影响因子：
0
作者：
Adler, Daniel A;Tseng, Emily;Choudhury, Tanzeem
通讯作者：
Choudhury, Tanzeem

Treatment Adequacy and Adherence as Predictors of Depression Response in Primary Care.

DOI：
10.1016/j.jagp.2020.04.014
发表时间：
2020-11
期刊：
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
影响因子：
0
作者：
Sirey JA;Woods A;Solomonov N;Evans L;Banerjee S;Zanotti P;Alexopoulos G;Kales HC
通讯作者：
Kales HC

Criminal and Socially Inappropriate Behavior as Early Signs of Cognitive Decline.

犯罪和社交不当行为是认知衰退的早期迹象。