NHP MHC ALLELE DISCOVERY AND TYPING TECHNOLOGY DEVELOPMENT for transplantation studies

用于移植研究的 NHP MHC 等位基因发现和分型技术开发

• 批准号: 10018595
• 负责人: DANIEL GERAGHTY
• 金额: $ 1.06万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2020-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10018595
• 关键词: Alleles; Antigen-Antibody Complex; Communities; Contracts; Data Set; Databases; Frequencies; Genetic; Genomics; Genotype; Goals; Haplotypes; Human; Immunoglobulins; Immunology; Killer Cells; Knowledge; Major Histocompatibility Complex; Major Histocompatibility Complex Gene; Maps; Methods; Program Development; Receptor Gene; Research; Resolution; Resources; Translations; Transplantation; Vaccine Design; assay development; gene discovery; immunoglobulin receptor; knowledge base; nonhuman primate; technology development

“The goals of the NHP MHC Gene Discovery and Typing Development Program are to advance the detailed knowledge base of nonhuman primate (NHP) major histocompatibility complex (MHC) genetic loci, alleles, and haplotypes, and their frequencies; expand discovery and characterization of NHP killer-cell immunoglobulin-like receptors (KIRs) genes, alleles, haplotypes, and frequencies; and develop robust, high-throughput genotyping and haplotyping methods.”

NHP MHC基因发现和分型开发计划的目标是推进关于非人灵长类(NHP)主要组织相容性复合体(MHC)遗传位点、等位基因和单倍型及其频率的详细知识库；扩大NHP杀伤细胞免疫球蛋白样受体(KIR)基因、等位基因、单倍型和频率的发现和表征；并开发可靠、高通量的基因分型和单倍型分析方法。