Topic 394 - A versatile radiation-triggered phosphor platform for localized anti-cancer therapy

主题 394 - 用于局部抗癌治疗的多功能辐射触发磷光体平台

• 批准号: 10019804
• 负责人: Rao Papineni
• 金额: $ 29.98万
• 依托单位: PACT AND HEALTH, LLC
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-16 至 2020-06-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10019804
• 关键词: Benchmarking; Biodistribution; Cell Death; Complex; Detection; Dose; Drug Kinetics; Goals; In Vitro; Ionizing radiation; Light; Measures; Metastatic Pancreatic Adenocarcinoma; PUVA Photochemotherapy; Photosensitization; Photosensitizing Agents; Production; Radiation; Reactive Oxygen Species; Roentgen Rays; Source; cancer therapy; cytotoxic; in vivo; in vivo evaluation; irradiation; mouse model; nanocomplexes; nanoparticle; novel; technological innovation; tumor microenvironment; uptake

The goal of this project is to fabricate a novel nanoscintillator-photosensitizer complex for X-ray excited photodynamic therapy (XPDT). Herein, a low dose of X-rays (<1 Gy) is used to excite scintillating nanoparticles, which downconvert ionizing radiation to UV-vis light. Photosensitizers loaded onto the nanoscintillator complex absorb this UV-vis emission and generate cytotoxic reactive oxygen species (ROS) in the tumor microenvironment. The long-term objective is to overcome the depth limitation of light-activated photosensitizers through an unique X-ray excited photodynamic therapy platform (*XPDT), wherein a low dose of focal or generalized radiation can eradicate localized or metastatic pancreatic adenocarcinomas, respectively. Technological innovations include the fabrication of a novel nanocomplex, comparison between nanocomplexes using a novel scintillation detection platform, in vitro and in vivo testing, and the use of a novel excitation X-ray source.

本计画的目标是制备一种新型的纳米闪烁体-光敏剂复合物，以应用于X光激发光动力疗法。 在本文中，低剂量的X射线（<1戈伊）用于激发电离纳米颗粒，其将电离辐射下转换为UV-可见光。 装载到纳米闪烁体复合物上的光敏剂吸收这种紫外-可见光发射，并在肿瘤微环境中产生细胞毒性活性氧（ROS）。 长期目标是通过独特的X射线激发光动力治疗平台（*XPDT）克服光激活光敏剂的深度限制，其中低剂量的局灶性或全身性辐射可以分别根除局部或转移性胰腺癌。 技术创新包括制造一种新的纳米复合物，使用一种新的闪烁检测平台，在体外和体内测试，以及使用一种新的激发X射线源的纳米复合物之间的比较。