Phase II Trial of O6-Benzylguanine and Temozolomide in Pediatric Patients with H

这项研究是在两组儿童中枢神经系统肿瘤患者中进行的，一组是弥漫性内在脑桥胶质瘤患者，这是一种致命的疾病，主要发生在5-10岁的儿童身上，中位生存期<1年，另一组是复发性高级别胶质瘤患者，预后同样很差。这项研究分两个阶段进行。在16例患者中进行初始第一阶段;如果观察到客观缓解，则将扩大队列（第二阶段）。如果未观察到缓解，则该研究组的研究将关闭。我们已经达到了每组第一阶段的招募目标，高级别胶质瘤队列已经扩展到第二阶段。本研究继续满足儿科脑肿瘤联盟的招募目标。

The study is being performed in two groups of pediatric CNS tumor patients-those with diffuse intrinsic pontine glioma which is a deadly disease which primarily strikes children 5-10 years of age and has a median survival of <1 year, and recurent high-grade gliomas which also has a similarly poor prognosis. The study is being performed intwo stages. An initial first stage is performed in 16 patients; if an objective response is observed, the cohort will expand (second stage). If no responses are observed, the study for that arm will be closed. We have reached our accrual goals for the first stage of each arm. The high grade glioma cohort has been expanded to the second stage. This study continues to meet its accrual goals within the Pediatric Brain Tumor Consortium.