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Mechanistic insight into RNA-mediated toxicity of C9orf72-linked ALS/FTD

Mechanistic insight into RNA-mediated toxicity of C9orf72-linked ALS/FTD
C9orf72 连接的 ALS/FTD 的 RNA 介导毒性的机制见解
批准号:
10019613
负责人:
GARY J BASSELL
金额:
$19.13万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
已结题
起止时间:
2019-09-18 至 2022-08-31

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中文摘要
翻译
在C9orf72基因中扩增的GGGGCC (G4C2)六核苷酸重复序列最近被鉴定为
英文摘要
Expanded GGGGCC (G4C2) hexanucleotide repeats in the C9orf72 gene were recently identified as the most common genetic cause of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD), two neurodegenerative disorders with genetic and pathological overlap. Repeat-RNA-toxicity mediated by sequestering key RNA binding proteins is thought to play key roles in c9ALS/FTD pathogenesis. However, which RNA binding protein(s) might be sequestered by long G4C2 repeat RNAs is still unknown. We propose to identify RNA-protein interactions in c9ALS/FTD using disease-relevant repeat lengths and cell models, and by comparison to interacting-proteins of (TG3C2) repeats, a similar repeat expansion that leads to a clinically disparate disease Spinocerebellar Ataxia type 36 (SCA36). The identified RNA binding protein(s) by the G4C2 repeats will be further validated in c9ALS/FTD patient postmortem brain samples and its functions will be studied in iPS-derived motor neurons and in mice. Results from this proposal will provide new insight into the cellular cascades that cause neurodegeneration in c9ALS/FTD.
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  • 财政年份:
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