Developmental Center for Human Urinary Bladder Myogenic Mechanisms by Ion Channels in Health and Disease

抽象DC-HUB开发中心 本次P20计划拨款申请的目的是建立“人类尿路发育中心” 离子通道在健康和疾病中的生肌机制“(DC-HUB)，重点研究 离子通道在良性泌尿系统中的作用。离子通道在膀胱功能中扮演着重要的角色，但 仍有待发现。这项DC-Hub规划基金的目标是组织一个多学科的 田纳西大学健康科学中心(UTHSC)的合作项目。这样做的目的是 多学科协作计划是研究离子通道的作用及其调节机制 在正常和良性病理条件下的人膀胱中。该计划将调查 离子通道调节尿液的分子、细胞、组织和整个生物体(体内)机制 膀胱功能和功能障碍，导致良性泌尿系统新的药理靶点的确定 有迹象表明。我们的协作DC-HUB将由在基础和 临床泌尿学、生理学、药理学、电生理学、药物发现、生物化学和信号 转导。采用严格的跨学科方法，使用最先进的技术，我们将 从分子水平确定离子通道在膀胱功能中的作用及其调控机制 并将分离的细胞转化为完整的组织和整个生物体。我们的长期目标是建立一个有效的 多学科计划，开发安全有效的过度活动治疗控制的新策略 膀胱(OAB)。这项DC-HUB建议是基础科学和临床之间广泛合作的结果 UTHSC的药学和医学学院教员。我们在研究方面的卓越伙伴关系， 教育和社区宣传的基础是优势互补、相互尊重和真正的 热情创建一个新的研究中心，专注于离子通道在良性泌尿系统中的作用。到年底的时候 在P20计划授权期，我们将为我们的跨学科制定一个连贯的主题和战略 协作研究计划和建立互动和协作的研究项目，每个项目都有工作 在提交NIH U54级别或P01级别的拨款申请时，充分开发了假设和目标。我们的 由UTHSC教职员工和外部合作者组成的多学科研究团队与 本次NIH P20 RFA-DK-18-028征集的描述标准。因此，有很高的可能性 这一综合努力旨在成长为NIH U54级、多PI R01或P01级拨款。

ABSTRACT DC-HUB DEVELOPMENTAL CENTER The intention of this P20 planning grant application is to establish the “Developmental Center for Human Urinary Bladder Myogenic Mechanisms by Ion Channels in Health and Disease” (DC-HUB), focused on investigating the role of ion channels in benign urology. Ion channels play important roles in urinary bladder function, but much remains to be discovered. The objective of this DC-HUB planning grant is to organize a multidisciplinary collaborative program at the University of Tennessee Health Science Center (UTHSC). The goal of this multidisciplinary collaborative program is to examine the roles of ion channels and their regulatory mechanisms in the human urinary bladder under normal and benign pathological conditions. The program will investigate the molecular, cellular, tissue, and whole organism (in vivo) mechanisms by which ion channels regulate urinary bladder function and dysfunction, leading to identification of novel pharmacological targets for benign urological indications. Our collaborative DC-HUB will consist of investigators with demonstrated expertise in basic and clinical urology, physiology, pharmacology, electrophysiology, drug discovery, biochemistry, and signal transduction. Employing a rigorous interdisciplinary approach, using state-of-the-art techniques, we will determine the roles of ion channels and their regulatory mechanisms in urinary bladder function from molecules and isolated cells to intact tissues and whole organisms. Our long-term goal is to establish an effective multidisciplinary program to develop novel strategies for safe and effective therapeutic control of overactive bladder (OAB). This DC-HUB proposal is a result of extensive collaboration among basic science and clinical faculty at UTHSC from Colleges of Pharmacy and Medicine. Our partnership for excellence in research, education, and community outreach is grounded on complementary strengths, mutual respect, and a genuine passion to create a new Research Center focused on the role of ion channels in benign urology. By the end of this P20 planning grant period, we will develop a coherent theme and strategy for our interdisciplinary collaborative research program and establish interactive and collaborative research projects, each with working hypotheses and aims fully developed at the submission of an NIH U54-level or P01-level grant application. Our multidisciplinary research team involving UTHSC faculty and outside collaborators perfectly matches the description criteria for this current NIH P20 RFA-DK-18-028 solicitation. Therefore, there is a high likelihood for this integrative effort to grow into an NIH U54-level, multi-PI R01, or P01-level grant.