Drug Delivery and Nanotechnology Module

项目摘要-纳米技术 药物输送和纳米技术(DD&N)模块是一种可用的使能技术资源 对威尔默眼科研究所的教职员工来说，通过实现持续和有针对性的药物输送 玻璃体内、结膜下或全身给药，用于开发新的成像 技术。在当前时期，这些合作产生了许多国家卫生研究院的赠款， 出版物，许多专利许可，以及重大的翻译工作，具有多种治疗方法 由正在进行临床翻译的Wilmer P30团队开发的方法。Dd&N Take 利用威尔默眼科研究所的专业知识、技术和资源 纳米医学(CNM)。威尔默的纳米医学中心是DD&N的支柱 模块，并已发展到7名教员，与威尔默的15名以上教员和更多人合作 约翰·霍普金斯大学的100多名教职员工。Wilmer调查人员的要求(既有既定的，也有早期的 研究人员)用于开发和表征用于小分子的药物输送系统， 蛋白质和核酸的增长远远超出了国家核管理委员会现有的预算限制， 随着DD&N成为P30努力的组成部分。我们的合作努力导致了 青光眼、视神经损伤等治疗新方法的重大进展 早产儿视网膜病变、干眼症。DD&N模块将继续蓬勃发展并实现 P30合作者的重大发现。

PROJECT SUMMARY – NANOTECHNOLOGY The Drug Delivery and Nanotechnology (DD&N) module is an enabling technology resource available to faculty of the Wilmer Eye Institute, by enabling sustained and targeted delivery of drugs administered intravitreally, subconjunctivally, or systemically, and in developing novel imaging technologies. During the current period, the collaborations have resulted many NIH grants, publications, many patents licensed, and significant translational efforts, with multiple therapeutic approaches developed by the Wilmer P30 team undergoing clinical translation. DD&N takes advantage of the expertise, technologies, and resources of the Wilmer Eye Institute’s Center for Nanomedicine (CNM). The Center for Nanomedicine at Wilmer serves as an anchor for the DD&N module, and has grown to seven faculty, collaborating with more than 15 faculty in Wilmer and more than 100 faculty across Johns Hopkins. Demand by Wilmer investigators (both established and early investigators) for the development and characterization of drug delivery systems for small molecules, proteins, and nucleic acids have grown well beyond the available budgetary restrictions of the CNM, with the DD&N becoming an integral part of the P30 effort. Our collaborative efforts have led to significant progress in novel therapeutic approaches for the treatment of glaucoma, optic nerve injury, retinopathy of prematurity, and dry eye. The DD&N module will continue to thrive and enable significant discoveries by the P30 collaborators.