CPT-SMART for Treatment of PTSD and Cigarette Smoking
CPT-SMART 用于治疗 PTSD 和吸烟
基本信息
- 批准号:10041693
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-10-01 至 2024-09-30
- 项目状态:已结题
- 来源:
- 关键词:AbstinenceAftercareBehavior TherapyBehavioralBiological TestingBupropionCessation of lifeCigaretteClinicClinical TrialsCognitiveCotinineCounselingDataDrug usageEffectivenessEvidence based treatmentFinancial compensationFrightGeneral PopulationGoalsGuidelinesIncentivesIndividualInterventionManualsMeasuresMediatingMental disordersMonitorMorbidity - disease rateNicotinePharmaceutical PreparationsPopulationPopulations at RiskPositive ReinforcerPost-Traumatic Stress DisordersPrevalencePsychological reinforcementPublic HealthRandomizedRelapseSalivarySelf EfficacySmokeSmokerSmokingSmoking Cessation InterventionSubstance Use DisorderSymptomsTestingTherapeutic InterventionTimeTraumaTreatment EfficacyUnited StatesVeteransarmbasecigarette smokecigarette smokingcontingency managementdepressive symptomsdisabilitydiscountingdrug abstinenceeffective interventionefficacy evaluationevidence baseexperienceimprovedmedical specialtiesmedication compliancemortalitynegative affectpaymentpreventprogramspsychiatric symptomreduce symptomssmoking abstinencesmoking cessationsmoking interventionsubstance abuse treatmentsubstance misusesubstance use treatmenttest stripvoucher
项目摘要
Smoking is the leading cause of preventable illness, disability, and death in the United States. The rate of
smoking is disproportionately higher among Veterans with posttraumatic stress disorder (PTSD).
Unfortunately, smoking cessation efforts that are effective in the general population have shown limited
effectiveness in smokers with PTSD. The high smoking rate and difficulty with achieving abstinence indicate a
critical need to develop effective interventions for PTSD smokers. Our data indicate that negative affect and
trauma reminders are a significant antecedent of relapse for PTSD smokers. Further, despite evidence that
nicotine may exacerbate PTSD symptoms, many smokers with PTSD expect that smoking helps manage their
symptoms. In this context, an ideal strategy may be to combine evidence-based PTSD treatment with intensive
smoking cessation treatment to maximize quit rates in this at-risk population.
Cognitive processing therapy (CPT) is a well-established evidenced-based treatment for PTSD. We have
successfully developed a treatment manual that integrates CPT with guideline-concordant cognitive-behavioral
counseling for smoking cessation and is well-tolerated among Veterans with PTSD who smoke cigarettes. The
addition of more intensive smoking cessation treatment is expected to maximize quit rates in this population.
Contingency management (CM) is an intensive behavioral treatment that has demonstrated efficacy for
reducing smoking in a range of difficult-to-treat populations, including individuals with psychiatric disorders. CM
provides positive reinforcers (e.g., vouchers, money) to individuals misusing substances contingent upon
bioverified abstinence from drug use. In combination with other treatment, CM may provide a potent initial
incentive in smokers who experience difficulties early in the quit attempt. The primary goal of the current study
is to evaluate the efficacy of an intervention that combines clinic-based CM using twice weekly monitoring with
salivary cotinine test strips, cognitive-behavioral smoking cessation counseling, smoking cessation medication,
and evidence-based PTSD treatment. Proposed is a randomized, two-arm clinical trial in which 120 Veteran
smokers with PTSD will be randomized to either: 1) COGNITIVE PROCESSING THERAPY with SMOKING
ABSTINENCE REINFORCEMENT THERAPY (CPT-SMART) – an intervention that combines evidenced-
based PTSD treatment with guideline-concordant cognitive-behavioral smoking cessation counseling,
bupropion, and intensive behavioral therapy through CM; or 2) COMBINED CONTACT CONTROL: an
intervention identical to CPT-SMART in PTSD and smoking treatment, except for using non-contingent
payment (i.e., yoked CM) to control for compensation and monitoring.
Specific aims include: AIM 1) To evaluate the efficacy of CPT-SMART on rates of short- and long-term
abstinence from cigarettes (assessed with multiple measures including bioverified abstinence) measured at 1-
week post-treatment, 3-months, and 6 months; AIM 2) To evaluate the impact of CPT-SMART on treatment
engagement and utilization; and an EXPLORATORY AIM) To explore mechanisms of CPT-SMART on long-
term smoking abstinence, including self-efficacy, salience of smoking, and psychiatric symptom reduction. The
VA has already implemented CM for treatment of substance abuse. If shown efficacious, a combined PTSD
treatment plus incentive-based approaches for smoking could be implemented into specialty PTSD programs.
The positive public health impact of reducing smoking among Veterans with PTSD could be enormous as it
would prevent significant smoking-related morbidity and mortality.
在美国,吸烟是导致可预防疾病、残疾和死亡的主要原因。的速度
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Eric A Dedert其他文献
Circadian disruption in women with breast cancer.
乳腺癌女性的昼夜节律紊乱。
- DOI:
- 发表时间:
2007 - 期刊:
- 影响因子:0
- 作者:
Eric A Dedert - 通讯作者:
Eric A Dedert
Self- and Other-Directed Violence as Outcomes of Deployment-Based Military Sexual Assault
部署军事性侵犯的结果是自我暴力和他人暴力
- DOI:
- 发表时间:
2020 - 期刊:
- 影响因子:0
- 作者:
L. Wilson;Amie R. Newins;S. Wilson;E. Elbogen;Eric A Dedert;P. Calhoun;J. Beckham;Va Mid;N. Kimbrel - 通讯作者:
N. Kimbrel
Roles of Guilt Cognitions in Trauma-Related Sleep Disturbance in Military Veterans With Posttraumatic Stress Disorder
内疚认知在患有创伤后应激障碍的退伍军人创伤相关睡眠障碍中的作用
- DOI:
- 发表时间:
2019 - 期刊:
- 影响因子:0
- 作者:
Eric A Dedert;Paul A. Dennis;Katherine C. Cunningham;C. Ulmer;P. Calhoun;N. Kimbrel;Terrell A Hicks;J. Neal;J. Beckham - 通讯作者:
J. Beckham
Multi-Component Smoking Cessation Treatment including Mobile Contingency Management for Smoking Cessation in Homeless Veteran Smokers
多成分戒烟治疗,包括针对无家可归的退伍军人戒烟的移动应急管理
- DOI:
- 发表时间:
2015 - 期刊:
- 影响因子:0
- 作者:
Vickie L. Carpenter;Jeffrey S. Hertzberg;A. Kirby;S. Patrick;Calhoun;S. Moore;Michelle F. Dennis;A. Paul;Dennis;Eric A Dedert;Lauren P. Hair;J. Beckham - 通讯作者:
J. Beckham
Childhood trauma and diurnal cortisol disruption in fibromyalgia syndrome
纤维肌痛综合征中的童年创伤和昼间皮质醇破坏
- DOI:
10.1016/j.psyneuen.2005.08.009 - 发表时间:
2006 - 期刊:
- 影响因子:3.7
- 作者:
I. Weissbecker;Andrea R. Floyd;Eric A Dedert;P. Salmon;S. Sephton - 通讯作者:
S. Sephton
Eric A Dedert的其他文献
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{{ truncateString('Eric A Dedert', 18)}}的其他基金
CPT-SMART for Treatment of PTSD and Cigarette Smoking
CPT-SMART 用于治疗 PTSD 和吸烟
- 批准号:
10594392 - 财政年份:2019
- 资助金额:
-- - 项目类别:
CPT-SMART for Treatment of PTSD and Cigarette Smoking
CPT-SMART 用于治疗 PTSD 和吸烟
- 批准号:
10295154 - 财政年份:2019
- 资助金额:
-- - 项目类别:
Combined Smoking Cessation and Cognitive Processing Therapy for PTSD
戒烟和认知加工疗法联合治疗创伤后应激障碍
- 批准号:
9336819 - 财政年份:2013
- 资助金额:
-- - 项目类别:
Combined Smoking Cessation and Cognitive Processing Therapy for PTSD
戒烟和认知加工疗法联合治疗创伤后应激障碍
- 批准号:
8542978 - 财政年份:2013
- 资助金额:
-- - 项目类别:
Combined Smoking Cessation and Cognitive Processing Therapy for PTSD
戒烟和认知加工疗法联合治疗创伤后应激障碍
- 批准号:
8704103 - 财政年份:2013
- 资助金额:
-- - 项目类别:
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