The intersection of development and innate immune system function in Arabidopsis
拟南芥发育与先天免疫系统功能的交叉点
基本信息
- 批准号:10001536
- 负责人:
- 金额:$ 26.59万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-09-01 至 2023-08-31
- 项目状态:已结题
- 来源:
- 关键词:AffectAnimalsAntirrhinumArabidopsisBiochemicalBiological ProcessBiologyCell physiologyCellsCellular biologyComplexConflict (Psychology)CuesDataDevelopmentDifferentiation and GrowthEatingEcosystemEquilibriumEukaryotaEvolutionFamilyFamily memberFiberFosteringFundingGene FamilyGenesGeneticGenetic PolymorphismGenetic TranscriptionGenomicsGoalsGrowthGrowth and Development functionHealthHome environmentHormonalHost DefenseHumanImmuneImmune responseImmune systemImmunityImmunologic MonitoringImmunologic ReceptorsInfectionInnate Immune ResponseInnate Immune SystemInsectaInvestigationLifeLife StyleMaizeMediatingModelingMolecularMossesMutationNatural ImmunityNormal CellOomycetesOxygenPersonal SatisfactionPhysiologyPhytoplasmaPlant Growth RegulatorsPlantsProcessProductivityProliferating Cell Nuclear AntigenProteinsRecording of previous eventsRegulonReportingResearchResearch SupportResource AllocationResourcesRiceSignal TransductionSpecificityStressStructureSystemUnited States National Institutes of HealthVirulenceVirulence FactorsZea luxuriansbasecellular targetingextracellularfeedingfitnessgenome-widehuman pathogenimmune functionimmune system functioninterestmembernovelpathogenpathogenic microbeplant growth/developmentprogramsreceptorreceptor functionreproductive successresponsesymbionttranscription factor
项目摘要
PROJECT ABSTRACT
Plants are critical for human health and well being. We eat plants, or animals that ate plants before we ate
them; we use plant fibers for our clothes and our homes; we rely on plants to provide ecosystems conducive to
environmental well being. Plants provide us with oxygen. Without plants, human life would be impossible.
Hence, research to understand plant growth, health and productivity is explicitly relevant to human health and
well being, as stressed in the 2009 NRC report: `A New Biology for the 21st Century'.
Plant research contributes significantly to understanding of basic processes in humans. Relevant to this
proposal is the finding that the intracellular receptors that are major regulators of the plant immune system are
structurally and functionally analogous to similar receptors functioning in animal innate immune systems. The
experimental ease of Arabidopsis genetics, genomics, and cell biology leads to discoveries about fundamental
processes shared across all eukaryotes, especially those that cross reference normal development with a
host's response to microbial pathogens, the focus of this proposal.
This project takes advantage of completed and current NIH supported research revealing how the effector
protein (virulence factor) repertoires from a bacterial, a fungal and a eukaryotic oomycete pathogen converge
onto an interconnected set of intracellular host targets. This convergence is striking as these three pathogens
are separated by ~2 billion years of evolution and have very different life styles and virulence mechanisms.
These data supported the overall hypothesis that pathogens usurp normal developmental and cell biological
processes to counteract host immune responses.
The long term goal of this research is to understand the functional processes of development and immunity
governed by a subset of ancient and conserved transcription factors, called TCPs, that are repeatedly targeted
by diverse pathogen effectors, and that form a tight sub-network in the current Arabidopsis interactome. TCP
proteins are well-characterized regulators of development, but novel players in defense.
This competitive renewal proposal will dissect the molecular mechanism of transcriptional coordination across
conflicting developmental and defense cues. TCP genes are an ancient gene family found in pteridophytes,
lycophytes, moss and some algal species, representing an evolutionary history of about 650 million years. This
enables study of the co-evolution of TCP protein developmental and immune functions. We are specifically
interested in understanding how a subset of TCP proteins controls the intersection of normal cell signaling for
growth and development and how the repeated evolution of diverse effectors that target these TCPs
manipulates the regulons they control to favor the proliferation of pathogens with diverse lifestyles.
This research will benefit investigations of animal pathogens, since effector proteins from human pathogens
also manipulate normal host cell physiology by targeting critical regulators of normal cell function.
项目摘要
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Convergent targeting of a common host protein-network by pathogen effectors from three kingdoms of life.
- DOI:10.1016/j.chom.2014.08.004
- 发表时间:2014-09-10
- 期刊:
- 影响因子:30.3
- 作者:Weßling R;Epple P;Altmann S;He Y;Yang L;Henz SR;McDonald N;Wiley K;Bader KC;Gläßer C;Mukhtar MS;Haigis S;Ghamsari L;Stephens AE;Ecker JR;Vidal M;Jones JD;Mayer KF;Ver Loren van Themaat E;Weigel D;Schulze-Lefert P;Dangl JL;Panstruga R;Braun P
- 通讯作者:Braun P
LSU network hubs integrate abiotic and biotic stress responses via interaction with the superoxide dismutase FSD2.
- DOI:10.1093/jxb/erw498
- 发表时间:2017-02-01
- 期刊:
- 影响因子:6.9
- 作者:Garcia-Molina A;Altmann M;Alkofer A;Epple PM;Dangl JL;Falter-Braun P
- 通讯作者:Falter-Braun P
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JEFFERY L. DANGL的其他文献
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{{ truncateString('JEFFERY L. DANGL', 18)}}的其他基金
The intersection of development and innate immune system function in Arabidopsis
拟南芥发育与先天免疫系统功能的交叉点
- 批准号:
9383523 - 财政年份:2013
- 资助金额:
$ 26.59万 - 项目类别:
The intersection of development and innate immune system function in Arabidopsis.
拟南芥发育与先天免疫系统功能的交叉点。
- 批准号:
9127272 - 财政年份:2013
- 资助金额:
$ 26.59万 - 项目类别:
The intersection of development and innate immune system function in Arabidopsis.
拟南芥发育与先天免疫系统功能的交叉点。
- 批准号:
8913221 - 财政年份:2013
- 资助金额:
$ 26.59万 - 项目类别:
The intersection of development and innate immune system function in Arabidopsis.
拟南芥发育与先天免疫系统功能的交叉点。
- 批准号:
8561801 - 财政年份:2013
- 资助金额:
$ 26.59万 - 项目类别:
The intersection of development and innate immune system function in Arabidopsis.
拟南芥发育与先天免疫系统功能的交叉点。
- 批准号:
8721458 - 财政年份:2013
- 资助金额:
$ 26.59万 - 项目类别:
Genetics of Programmed Cell Death in Arabidoposis
拟南芥程序性细胞死亡的遗传学
- 批准号:
7887640 - 财政年份:2009
- 资助金额:
$ 26.59万 - 项目类别:
Diversity and evolution of P syringae type III effectors
丁香假单胞菌III型效应子的多样性和进化
- 批准号:
7006951 - 财政年份:2004
- 资助金额:
$ 26.59万 - 项目类别:
Diversity and evolution of Pseudomonas syringae type III effectors (RO1GM066025)
丁香假单胞菌 III 型效应子的多样性和进化 (RO1GM066025)
- 批准号:
7619486 - 财政年份:2004
- 资助金额:
$ 26.59万 - 项目类别:
Diversity and evolution of P syringae type III effectors
丁香假单胞菌III型效应子的多样性和进化
- 批准号:
7158585 - 财政年份:2004
- 资助金额:
$ 26.59万 - 项目类别:
Diversity and evolution of P syringae type III effectors
丁香假单胞菌III型效应子的多样性和进化
- 批准号:
6730041 - 财政年份:2004
- 资助金额:
$ 26.59万 - 项目类别:
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