Project-002

项目-002

• 批准号: 10004134
• 负责人: MARC D. BASSON
• 金额: $ 18.19万
• 依托单位: UNIVERSITY OF NORTH DAKOTA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10004134
• 关键词: Accounting; Address; Advocate; Affect; Age; American Indians; Applications Grants; Area; Biology; Biomedical Research; Biometry; Cancer Biology; Caring; Cause of Death; Center for Translational Science Activities; Centers of Research Excellence; Cessation of life; Clinical; Clinical Investigator; Clinical Research; Communities; Community Health; Community Medicine; Core Facility; Data; Development; Diagnosis; Disease Surveillance; Educational Curriculum; Ensure; Environment; Epidemiology; Epigenetic Process; Evaluation; Faculty; Family Practice; Funding; Goals; Government; Grant; Growth; Health; Health Promotion; Health Sciences; Home environment; Hospitals; Human; Incidence; Individual; Infrastructure; Institution; Intervention; Lead; Link; Malignant Neoplasms; Methods; NCI Center for Cancer Research; Nature; Neoplasm Metastasis; Neurodegenerative Disorders; North Dakota; Outcome; Pathway interactions; Patients; Physicians; Physiology; Pilot Projects; Population; Population Study; Positioning Attribute; Prevalence; Process; Research; Research Design; Research Personnel; Research Project Grants; Research Training; Resources; Rivers; Rural Health; Rural Health Centers; Science; Scientist; Site; Social Class; South Dakota; State Hospitals; Suggestion; System; Testing; Time; Training; Translating; Translational Research; Treatment Cost; Universities; Woman; Work; anticancer research; base; clinically relevant; combat; cost effectiveness; design; effective therapy; epidemiology study; immunoregulation; improved; innovation; interdisciplinary approach; investigator training; medical schools; men; mortality; novel; outreach; outreach program; patient safety; population based; population health; programs; recruit; research facility; rural Americans; social health determinants; socioeconomics; success; translational cancer research; translational scientist; tumor progression; volunteer

Summary: The objective of this grant application is to create a center to support and expand our ability to conduct full-spectrum clinical and translational research on various cancers. Establishing the Dakota Cancer Collaborative on Translational Activity (DACCOTA) will also allow us for the first time to apply our basic scientific and epidemiologic work to the clinical arena while training clinician-investigator partners to translate these discoveries. We will train basic scientists to conduct translational work, population health experts to understand the community determinants of cancer outcomes, and clinicians to collaborate. The DACCOTA will promote and facilitate interactions between clinicians and scientists with unique but complementary areas of expertise. Our goal is to develop a highly productive, collaborative, and sustainable translational research center that will focus on the cancers that most commonly and disproportionately afflict the citizens of our region, especially American Indians. We have proposed independent cores, all led by capable investigators, that will assist in building a competitive clinical and translational cancer research center. The DACCOTA will provide an academic home for clinical and translational scientists and trainees. These investigators will focus on understanding the mechanisms leading to the initiation and progression of cancer, which will facilitate the development of novel and effective treatments and improve disease surveillance. This is necessary due to the increase in cancer prevalence and mortality in the Dakota region and throughout the USA. The DACCOTA will have further impact by validating new ways of developing and supporting individuals to facilitate team-based science addressing critical issues affecting the region. Our Professional Development Core will develop aspiring investigators and train practicing "real world“ clinicians to become more avid and effective collaborators. Applicants for pilot grants will be required to propose teams including an investigator and clinician. The Community Enagement and Outreach Core will help recruit volunteers, seek advice about overall directions, and work with community leaders to designate specific cancer-related issues of community concern for RFA’s that will be funneled through the Pilot Projects Program. In addition to the community-based natures of the University of North Dakota (UND), North Dakota State University (NDSU), and the University of South Dakota (USD), the collaborating hospitals in this proposal cover more than 90% of the region and include multiple innovative departments of family and community medicine as well as rural and population health. There are also three MPH programs between these institutions. Thus, we are superbly positioned to conduct clinical research encompassing the entire region. Similarly, the Biostatistics, Epidemiology, and Research Design Core and the Clinical Research Resources and Facilites Core will combine their strengths and develop new resources to enhance clinical research. Finally, our Tracking and Evaluation Core will use innovative methods to evaluate these novel processes as well as provide suggestions to improve efficiency and ensure both cost-effectiveness and improved patient safety. UND, NDSU, USD, and all clinical partners are fully committed to ensuring the growth and sustainability of the DACCOTA even after the CTR grant ends.

摘要：这项拨款申请的目的是建立一个中心来支持和扩展我们的能力