Project-002

项目-002

• 批准号: 10004134
• 负责人: MARC D. BASSON
• 金额: $ 18.19万
• 依托单位: UNIVERSITY OF NORTH DAKOTA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10004134
• 关键词: Accounting; Address; Advocate; Affect; Age; American Indians; Applications Grants; Area; Biology; Biomedical Research; Biometry; Cancer Biology; Caring; Cause of Death; Center for Translational Science Activities; Centers of Research Excellence; Cessation of life; Clinical; Clinical Investigator; Clinical Research; Communities; Community Health; Community Medicine; Core Facility; Data; Development; Diagnosis; Disease Surveillance; Educational Curriculum; Ensure; Environment; Epidemiology; Epigenetic Process; Evaluation; Faculty; Family Practice; Funding; Goals; Government; Grant; Growth; Health; Health Promotion; Health Sciences; Home environment; Hospitals; Human; Incidence; Individual; Infrastructure; Institution; Intervention; Lead; Link; Malignant Neoplasms; Methods; NCI Center for Cancer Research; Nature; Neoplasm Metastasis; Neurodegenerative Disorders; North Dakota; Outcome; Pathway interactions; Patients; Physicians; Physiology; Pilot Projects; Population; Population Study; Positioning Attribute; Prevalence; Process; Research; Research Design; Research Personnel; Research Project Grants; Research Training; Resources; Rivers; Rural Health; Rural Health Centers; Science; Scientist; Site; Social Class; South Dakota; State Hospitals; Suggestion; System; Testing; Time; Training; Translating; Translational Research; Treatment Cost; Universities; Woman; Work; anticancer research; base; clinically relevant; combat; cost effectiveness; design; effective therapy; epidemiology study; immunoregulation; improved; innovation; interdisciplinary approach; investigator training; medical schools; men; mortality; novel; outreach; outreach program; patient safety; population based; population health; programs; recruit; research facility; rural Americans; social health determinants; socioeconomics; success; translational cancer research; translational scientist; tumor progression; volunteer

Summary: The objective of this grant application is to create a center to support and expand our ability to conduct full-spectrum clinical and translational research on various cancers. Establishing the Dakota Cancer Collaborative on Translational Activity (DACCOTA) will also allow us for the first time to apply our basic scientific and epidemiologic work to the clinical arena while training clinician-investigator partners to translate these discoveries. We will train basic scientists to conduct translational work, population health experts to understand the community determinants of cancer outcomes, and clinicians to collaborate. The DACCOTA will promote and facilitate interactions between clinicians and scientists with unique but complementary areas of expertise. Our goal is to develop a highly productive, collaborative, and sustainable translational research center that will focus on the cancers that most commonly and disproportionately afflict the citizens of our region, especially American Indians. We have proposed independent cores, all led by capable investigators, that will assist in building a competitive clinical and translational cancer research center. The DACCOTA will provide an academic home for clinical and translational scientists and trainees. These investigators will focus on understanding the mechanisms leading to the initiation and progression of cancer, which will facilitate the development of novel and effective treatments and improve disease surveillance. This is necessary due to the increase in cancer prevalence and mortality in the Dakota region and throughout the USA. The DACCOTA will have further impact by validating new ways of developing and supporting individuals to facilitate team-based science addressing critical issues affecting the region. Our Professional Development Core will develop aspiring investigators and train practicing "real world“ clinicians to become more avid and effective collaborators. Applicants for pilot grants will be required to propose teams including an investigator and clinician. The Community Enagement and Outreach Core will help recruit volunteers, seek advice about overall directions, and work with community leaders to designate specific cancer-related issues of community concern for RFA’s that will be funneled through the Pilot Projects Program. In addition to the community-based natures of the University of North Dakota (UND), North Dakota State University (NDSU), and the University of South Dakota (USD), the collaborating hospitals in this proposal cover more than 90% of the region and include multiple innovative departments of family and community medicine as well as rural and population health. There are also three MPH programs between these institutions. Thus, we are superbly positioned to conduct clinical research encompassing the entire region. Similarly, the Biostatistics, Epidemiology, and Research Design Core and the Clinical Research Resources and Facilites Core will combine their strengths and develop new resources to enhance clinical research. Finally, our Tracking and Evaluation Core will use innovative methods to evaluate these novel processes as well as provide suggestions to improve efficiency and ensure both cost-effectiveness and improved patient safety. UND, NDSU, USD, and all clinical partners are fully committed to ensuring the growth and sustainability of the DACCOTA even after the CTR grant ends.

摘要：本次拨款申请的目的是创建一个中心来支持和扩展我们的能力 对各种癌症进行全谱临床和转化研究。建立达科他州 癌症转化活动合作组织 (DACCOTA) 也将允许我们首次应用我们的 临床领域的基础科学和流行病学工作，同时培训临床医生-研究者合作伙伴 翻译这些发现。我们将培训基础科学家进行转化工作、人口健康 专家了解癌症结果的社区决定因素，并与临床医生合作。这 DACCOTA 将促进和促进临床医生和科学家之间的互动，其独特但 互补的专业领域。我们的目标是开发一个高生产力、协作性和 可持续转化研究中心将重点关注最常见和最常见的癌症 我们地区的公民，尤其是美洲印第安人，受到了不成比例的折磨。我们提出了 独立的核心，全部由有能力的研究人员领导，这将有助于建立一个有竞争力的临床和 转化癌症研究中心。 DACCOTA 将为临床和 转化科学家和实习生。这些研究人员将重点了解其机制 导致癌症的发生和进展，这将促进新的和 有效治疗并改善疾病监测。由于癌症的增加，这是必要的 达科他州地区和整个美国的患病率和死亡率。 DACCOTA 将进一步 通过验证开发和支持个人促进基于团队的科学的新方法来产生影响 解决影响该地区的关键问题。我们的专业发展核心将培养有抱负的人 调查人员并培训执业的“现实世界”临床医生，使其成为更加热心和有效的合作者。 试点资助的申请人将需要提议包括一名研究者和临床医生的团队。这 社区参与和外展核心将帮助招募志愿者，寻求整体建议 方向，并与社区领袖合作指定社区中与癌症相关的具体问题 对 RFA 的关注将通过试点项目计划得到解决。除了基于社区的 北达科他大学 (UND)、北达科他州立大学 (NDSU) 的性质 南达科他大学（USD），本提案中的合作医院覆盖了90%以上 地区，包括家庭和社区医学以及农村和农村地区的多个创新部门 人口健康。这些机构之间还存在三个 MPH 项目。因此，我们非常出色 定位于开展覆盖整个地区的临床研究。同样，生物统计学， 流行病学、研究设计核心和临床研究资源和设施核心将 结合他们的优势并开发新资源以加强临床研究。最后，我们的追踪 评估核心将使用创新方法来评估这些新颖的流程，并提供 提高效率并确保成本效益和改善患者安全的建议。联合国, NDSU、USD 和所有临床合作伙伴完全致力于确保该项目的增长和可持续性 DACCOTA 即使在 CTR 补助结束后也是如此。