Project 1: Host Immune Response to Chronic Psoriasis Inflammation

项目 1:宿主对慢性银屑病炎症的免疫反应

基本信息

  • 批准号:
    10005125
  • 负责人:
  • 金额:
    $ 33.34万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2017
  • 资助国家:
    美国
  • 起止时间:
    2017-09-20 至 2022-08-31
  • 项目状态:
    已结题

项目摘要

The overall goal of the CWRU Psoriasis Center of Research Translation (CORT) is to combine new bioinformatic methodologies with advanced murine and human experimental approaches to translate scientific findings into clinical applications that more nimbly advance therapy for psoriasis and related inflammatory comorbidities. Our highly innovative, synergistic and cross-disciplinary CORT will use a collaborative research project (CRP) as a central hub with bi-directional input from 2 highly interactive research cores, to refine and test hypotheses, identify and test repurposed drug leads and advance understanding of psoriasis and related inflammatory comorbidities. To do so, the CRP will integrate input from the: 1) Preclinical Modeling Core (PMC), that will provide and customize our many validated, unique transgenic psoriasiform animal models and translatable human xenograft approaches, essential to translating new mediator/pathway roles and drug leads; and the 2) Applied Meta-‘Omics Core (AMC), that will apply multi-platform (transcriptome, metabolome, micro/mycobiome) bioinformatics to individual patient and murine samples to identify novel pathway-specific targets. Iterative experimental testing of these targets and feedback from the PMC and CRP will identify novel pathways in psoriasis pathogenesis that are likely to benefit from intervention by new or repurposed drugs that will translate to psoriasis therapy. Our overarching hypothesis is that we can powerfully combine existing and developing psoriasis basic science datasets, patient records, bioinformatics and computational systems biology with bi-directional mouse and human studies to identify new therapeutic targets and repurposed drugs that can be expeditiously moved to clinical trials, improving psoriasis treatment and patient care. To test and refine this hypothesis, the Specific Aims are: (1) Identify new pathways central to psoriasis pathogenesis and new psoriasis drug candidates by analyzing psoriasis patients' EMR data, tissue and blood samples and; (2) Evaluate AMC-identified gene targets and efficacy of pathway-specific drug candidates using preclinical molecular genetic psoriasis mouse models. The concentrated interactions between the CRP and Cores will provide value-added research output, far beyond any incremental advances that a given Core or specific project could provide. Our novel, highly integrated and synergistic CORT design, powered by exceptional resources and expertise of our interdisciplinary translational investigative team, will exert a transformative and sustainable impact on the psoriasis field and patient care.
CWRU银屑病研究翻译中心(CORT)的总体目标是结合新的

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Nicole Leanne Ward其他文献

Nicole Leanne Ward的其他文献

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{{ truncateString('Nicole Leanne Ward', 18)}}的其他基金

Kallikrein-PAR interactions in skin inflammation
激肽释放酶-PAR 在皮肤炎症中的相互作用
  • 批准号:
    10208722
  • 财政年份:
    2018
  • 资助金额:
    $ 33.34万
  • 项目类别:
Kallikrein-PAR interactions in skin inflammation
激肽释放酶-PAR 在皮肤炎症中的相互作用
  • 批准号:
    10615327
  • 财政年份:
    2018
  • 资助金额:
    $ 33.34万
  • 项目类别:
Kallikrein-PAR interactions in skin inflammation
激肽释放酶-PAR 在皮肤炎症中的相互作用
  • 批准号:
    10449979
  • 财政年份:
    2018
  • 资助金额:
    $ 33.34万
  • 项目类别:
Core 1: Pre-clinical Modeling Core
核心 1:临床前建模核心
  • 批准号:
    10005123
  • 财政年份:
    2017
  • 资助金额:
    $ 33.34万
  • 项目类别:
Project 1: Host Immune Response to Chronic Psoriasis Inflammation
项目 1:宿主对慢性银屑病炎症的免疫反应
  • 批准号:
    10259876
  • 财政年份:
    2017
  • 资助金额:
    $ 33.34万
  • 项目类别:
Core 1: Pre-clinical Modeling Core
核心 1:临床前建模核心
  • 批准号:
    10259874
  • 财政年份:
    2017
  • 资助金额:
    $ 33.34万
  • 项目类别:
IL-17C mediated mechanisms of inflammation
IL-17C 介导的炎症机制
  • 批准号:
    8445590
  • 财政年份:
    2013
  • 资助金额:
    $ 33.34万
  • 项目类别:
Neurogenic inflammation and psoriasiform dermatitis
神经源性炎症和牛皮癣样皮炎
  • 批准号:
    8706044
  • 财政年份:
    2013
  • 资助金额:
    $ 33.34万
  • 项目类别:
IL-17C mediated mechanisms of inflammation
IL-17C 介导的炎症机制
  • 批准号:
    8636995
  • 财政年份:
    2013
  • 资助金额:
    $ 33.34万
  • 项目类别:
IL-17C mediated mechanisms of inflammation
IL-17C 介导的炎症机制
  • 批准号:
    9039538
  • 财政年份:
    2013
  • 资助金额:
    $ 33.34万
  • 项目类别:

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