Project 1: Host Immune Response to Chronic Psoriasis Inflammation
项目 1:宿主对慢性银屑病炎症的免疫反应
基本信息
- 批准号:10005125
- 负责人:
- 金额:$ 33.34万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-09-20 至 2022-08-31
- 项目状态:已结题
- 来源:
- 关键词:Advisory CommitteesAnimal ModelArtificial IntelligenceBasic ScienceBioinformaticsBloodBlood specimenCellsChronicClinicalClinical ResearchClinical TrialsComplexCritical PathwaysCustomDataData SetDatabasesDecision MakingDevelopmentDiseaseDrug TargetingFeedbackGene TargetingGenesGeneticGoalsGrowthHealthcareHumanHuman ResourcesImmune responseInflammationInflammatoryInterventionIntervention StudiesLeadLeadershipMachine LearningMediator of activation proteinMedicalMethodologyMethodsModelingMolecular GeneticsMusOhioOutputPathogenesisPathway interactionsPatient CarePatientsPharmaceutical PreparationsPhenotypePilot ProjectsPre-Clinical ModelProviderPsoriasisPsoriatic ArthritisRecordsResearchResearch Project GrantsResource AllocationResourcesRoleSamplingSkinSystemSystems BiologyTestingTherapeuticTissue SampleTransgenic OrganismsTranslatingTranslational ResearchXenograft procedurebaseclinical applicationcohesioncomorbiditydata miningdesigndrug candidatedrug discoverydrug testingimprovedin silicoin vitro Bioassayindividual patientinflammatory markerinnovationinsightmeetingsmetabolomemicrobiomemouse modelmycobiomenew therapeutic targetnovelnovel therapeuticspatient orientedpatient stratificationpersonalized medicinepersonalized predictionspost interventionpre-clinicalpre-clinical researchprogramsrepositorysynergismtherapy designtranscriptometranslational approach
项目摘要
The overall goal of the CWRU Psoriasis Center of Research Translation (CORT) is to combine new
bioinformatic methodologies with advanced murine and human experimental approaches to translate scientific
findings into clinical applications that more nimbly advance therapy for psoriasis and related inflammatory
comorbidities. Our highly innovative, synergistic and cross-disciplinary CORT will use a collaborative research
project (CRP) as a central hub with bi-directional input from 2 highly interactive research cores, to refine and
test hypotheses, identify and test repurposed drug leads and advance understanding of psoriasis and related
inflammatory comorbidities. To do so, the CRP will integrate input from the: 1) Preclinical Modeling Core
(PMC), that will provide and customize our many validated, unique transgenic psoriasiform animal models and
translatable human xenograft approaches, essential to translating new mediator/pathway roles and drug leads;
and the 2) Applied Meta-‘Omics Core (AMC), that will apply multi-platform (transcriptome, metabolome,
micro/mycobiome) bioinformatics to individual patient and murine samples to identify novel pathway-specific
targets. Iterative experimental testing of these targets and feedback from the PMC and CRP will identify novel
pathways in psoriasis pathogenesis that are likely to benefit from intervention by new or repurposed drugs that
will translate to psoriasis therapy. Our overarching hypothesis is that we can powerfully combine existing and
developing psoriasis basic science datasets, patient records, bioinformatics and computational systems
biology with bi-directional mouse and human studies to identify new therapeutic targets and repurposed drugs
that can be expeditiously moved to clinical trials, improving psoriasis treatment and patient care. To test and
refine this hypothesis, the Specific Aims are: (1) Identify new pathways central to psoriasis pathogenesis and
new psoriasis drug candidates by analyzing psoriasis patients' EMR data, tissue and blood samples and; (2)
Evaluate AMC-identified gene targets and efficacy of pathway-specific drug candidates using preclinical
molecular genetic psoriasis mouse models. The concentrated interactions between the CRP and Cores will
provide value-added research output, far beyond any incremental advances that a given Core or specific
project could provide. Our novel, highly integrated and synergistic CORT design, powered by exceptional
resources and expertise of our interdisciplinary translational investigative team, will exert a transformative and
sustainable impact on the psoriasis field and patient care.
CWRU银屑病研究翻译中心(CORT)的总体目标是结合新的
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Nicole Leanne Ward其他文献
Nicole Leanne Ward的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Nicole Leanne Ward', 18)}}的其他基金
Kallikrein-PAR interactions in skin inflammation
激肽释放酶-PAR 在皮肤炎症中的相互作用
- 批准号:
10208722 - 财政年份:2018
- 资助金额:
$ 33.34万 - 项目类别:
Kallikrein-PAR interactions in skin inflammation
激肽释放酶-PAR 在皮肤炎症中的相互作用
- 批准号:
10615327 - 财政年份:2018
- 资助金额:
$ 33.34万 - 项目类别:
Kallikrein-PAR interactions in skin inflammation
激肽释放酶-PAR 在皮肤炎症中的相互作用
- 批准号:
10449979 - 财政年份:2018
- 资助金额:
$ 33.34万 - 项目类别:
Project 1: Host Immune Response to Chronic Psoriasis Inflammation
项目 1:宿主对慢性银屑病炎症的免疫反应
- 批准号:
10259876 - 财政年份:2017
- 资助金额:
$ 33.34万 - 项目类别:
Neurogenic inflammation and psoriasiform dermatitis
神经源性炎症和牛皮癣样皮炎
- 批准号:
8706044 - 财政年份:2013
- 资助金额:
$ 33.34万 - 项目类别:
相似海外基金
Quantification of Neurovasculature Changes in a Post-Hemorrhagic Stroke Animal-Model
出血性中风后动物模型中神经血管变化的量化
- 批准号:
495434 - 财政年份:2023
- 资助金额:
$ 33.34万 - 项目类别:
Bioactive Injectable Cell Scaffold for Meniscus Injury Repair in a Large Animal Model
用于大型动物模型半月板损伤修复的生物活性可注射细胞支架
- 批准号:
10586596 - 财政年份:2023
- 资助金额:
$ 33.34万 - 项目类别:
A Comparison of Treatment Strategies for Recovery of Swallow and Swallow-Respiratory Coupling Following a Prolonged Liquid Diet in a Young Animal Model
幼年动物模型中长期流质饮食后吞咽恢复和吞咽呼吸耦合治疗策略的比较
- 批准号:
10590479 - 财政年份:2023
- 资助金额:
$ 33.34万 - 项目类别:
Small animal model for evaluating the impacts of cleft lip repairing scar on craniofacial growth and development
评价唇裂修复疤痕对颅面生长发育影响的小动物模型
- 批准号:
10642519 - 财政年份:2023
- 资助金额:
$ 33.34万 - 项目类别:
Diurnal grass rats as a novel animal model of seasonal affective disorder
昼夜草鼠作为季节性情感障碍的新型动物模型
- 批准号:
23K06011 - 财政年份:2023
- 资助金额:
$ 33.34万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Longitudinal Ocular Changes in Naturally Occurring Glaucoma Animal Model
自然发生的青光眼动物模型的纵向眼部变化
- 批准号:
10682117 - 财政年份:2023
- 资助金额:
$ 33.34万 - 项目类别:
A whole animal model for investigation of ingested nanoplastic mixtures and effects on genomic integrity and health
用于研究摄入的纳米塑料混合物及其对基因组完整性和健康影响的整体动物模型
- 批准号:
10708517 - 财政年份:2023
- 资助金额:
$ 33.34万 - 项目类别:
A Novel Large Animal Model for Studying the Developmental Potential and Function of LGR5 Stem Cells in Vivo and in Vitro
用于研究 LGR5 干细胞体内外发育潜力和功能的新型大型动物模型
- 批准号:
10575566 - 财政年份:2023
- 资助金额:
$ 33.34万 - 项目类别:
Elucidating the pathogenesis of a novel animal model mimicking chronic entrapment neuropathy
阐明模拟慢性卡压性神经病的新型动物模型的发病机制
- 批准号:
23K15696 - 财政年份:2023
- 资助金额:
$ 33.34万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
The effect of anti-oxidant on swallowing function in an animal model of dysphagia
抗氧化剂对吞咽困难动物模型吞咽功能的影响
- 批准号:
23K15867 - 财政年份:2023
- 资助金额:
$ 33.34万 - 项目类别:
Grant-in-Aid for Early-Career Scientists