Psoriasis Center of Research Translation

银屑病研究翻译中心

• 批准号: 10005116
• 负责人: Kevin D Cooper
• 金额: $ 131.66万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-20 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10005116
• 关键词: Advisory Committees; Animal Model; Artificial Intelligence; Basic Science; Bioinformatics; Biological; Biological Markers; Biological Models; Blood Cells; Cells; Clinical; Clinical Trials; Computational Biology; Computational algorithm; Computerized Medical Record; Coupled; Critical Pathways; Custom; Cutaneous; Data; Data Analyses; Data Set; Databases; Decision Making; Development; Drug Targeting; Environment; FDA approved; Feedback; Gene Expression; Gene Targeting; Goals; Growth; Human; Human Resources; Immunology; Inflammatory; Interdisciplinary Study; Intervention; Laboratories; Leadership; Link; Machine Learning; Mediator of activation protein; Medical; Medical center; Methodology; Methods; Microbe; Modeling; Molecular; Mus; Ohio; Pathogenesis; Pathogenicity; Pathway interactions; Patient Care; Patients; Pharmaceutical Preparations; Pre-Clinical Model; Provider; Psoriasis; Psoriatic Arthritis; Records; Records Controls; Research; Research Project Grants; Resource Allocation; Resources; Role; Sampling; Skin; Systems Biology; Techniques; Technology; Testing; Transgenic Model; Transgenic Organisms; Translating; Translational Research; Universities; University Hospitals; Xenograft procedure; base; clinical application; cohesion; cohort; comorbidity; data mining; design; differential expression; drug development; drug discovery; drug testing; effective intervention; experience; improved; individual patient; inflammatory marker; innovation; meetings; metabolome; metabolomics; microbiome; multimodality; mycobiome; new therapeutic target; novel; novel strategies; novel therapeutics; patient oriented; pre-clinical; pre-clinical research; programs; repository; response; synergism; therapeutic target; transcriptome; transcriptomics; translational approach

The Psoriasis Center of Research Translation at Case Western Reserve University (CORT) will advance translational discovery and application in psoriasis using a cutting-edge systems biology approach that integrates patient-centered data within a rich and synergistic /collaborative institutional environment. We will leverage extensive preclinical, clinical and translational resources with the expertise and experience of our CWRU interdisciplinary research team, which encompasses bioinformatics, micro/myocobiome, psoriasis patient care, cutaneous immunology and transgenic models. The overall goal of the CORT is to combine new bioinformatic methodologies with advanced murine and human experimental approaches to translate scientific findings into clinical applications that more nimbly advance therapy for psoriasis and related inflammatory comorbidities. Our highly innovative, synergistic and cross-disciplinary CORT model will use a collaborative research project (CRP) as a central hub with bi- directional input from 2 highly interactive research cores, to refine and test hypotheses, identify and test drug leads and advance understanding of psoriasis and related inflammatory comorbidities. To do so, the CRP will integrate input from the: 1) Preclinical Modeling Core (PMC), that will provide and customize our many validated, unique transgenic psoriasiform animal models and translatable human xenograft approaches, essential to translating new mediator/pathway roles and drug leads; 2) Applied Meta-`Omics Core (AMC), that will apply multi-platform (transcriptome, metabolome, micro/mycobiome) bioinformatics to individual patient and murine samples to identify novel pathway-specific targets. Iterative experimental testing of these targets and feedback from the PMC and CRP will identify key novel pathways critical for psoriasis pathogenesis likely to benefit from intervention by new drugs or repurposed existing drugs for psoriasis therapy. Our patient-centered translational approach will exploit and enhance a novel, comprehensive and highly annotated database of ~850 psoriasis/psoriatic arthritis single-patient case records that combines clinical information derived from CLEARPATH (an Ohio medical provider consortium-based unified EMR repository for research access), with inflammation markers that stratify subsets. Into each patient's EMR, we will directly integrate his/her meta'Omics data created by the AMC working with the CRP, to create an 'Omics-integrated EMR (EMRi) data set. These cohesive multi-platform personal data records will identify psoriasis patient endotypes based upon unique perturbations identified from their “meta'Omics” analyses. Our overarching hypothesis is that by powerfully combining existing and developing psoriasis basic science datasets, patient records, bioinformatics and computational systems biology with bi-directional mouse and human studies, we will identify new therapeutic targets and repurposed drugs that can be expeditiously moved to clinical trials, improving psoriasis treatment and patient care.

凯斯西储大学牛皮癣研究翻译中心（CORT）将继续推进